环境医学与环境毒理学,主要内容包括：（1）环境污染物对血细胞损伤的分子机制；（2）环境肿瘤学及肿瘤进展的机理；（3）人工纳米材料的生物安全性。

   

083001-环境科学
0703Z1-化学生物学
071009-细胞生物学

环境肿瘤学，纳米生物学
环境毒理学，纳米生物学
环境医学与分子毒理学

2001-09--2004-07   中科院遗传发育所   博士

   

2008-02~2009-08,美国塔芙茨大学医学院, 讲师
2007-07~2008-01,美国哈佛大学医学院, 研究助理
2004-08~2007-06,美国麻省理工学院, 博士后

2012-02-27-今,国家环境与健康专家咨询委员会, 委员

环境毒理学研究方法
现代生物学技术在环境健康研究中的应用
环境污染与健康危害进展
环境与健康研究系列讲座
环境与健康研究进展

   

（1） 国家万人计划, 一等奖, 部委级, 2018
（2） 国家青年科技领军人才, 一等奖, 部委级, 2017
（3） 十四届中国青年科技奖, 国家级, 2016
（4） 中国科学院青年科学家奖, 一等奖, 院级, 2015
（5） 中国科学院青年科学家奖, 一等奖, 院级, 2015
（6） 中国科学院青年科学家奖, 一等奖, 院级, 2015
（7） 高登学术会议(Gordon conference)Nature Travel Award, 一等奖, 其他, 2015
（8） 高登学术会议(Gordon conference)Nature Travel Award, 一等奖, 其他, 2015
（9） 中科院2013年度杰出科技成就奖, 一等奖, 院级, 2015
（10） ****终期考评被评选为优秀, 一等奖, 院级, 2014
（11） 第九届PTS青年科学家奖, 一等奖, 国家级, 2012
（12） 美国骨与矿物质学会青年研究者奖, 一等奖, 其他, 2009

（ 1 ） 一种噻唑烷酮类化合物及其在制备治疗铁紊乱相关疾病药物中的应用, 实用新型, 2014, 第 2 作者, 专利号: 201410698860.7

   

[1] Yu Su, Bin Wang, Xin Tong, Shuchuan Peng, Sijin Liu, Baoshan Xing, Rong Ji. Steam disinfection enhances bioaccessibility of metallic nanoparticles in nano-enabled silicone-rubber baby bottle teats, pacifiers, and teethers. JOURNAL OF ENVIRONMENTAL SCIENCES. 2024, 136: 161-171, http://dx.doi.org/10.1016/j.jes.2022.08.001.
[2] Liu, Shuang, Dong, Jingcun, Fang, Xiaolong, Yan, Xueting, Zhang, He, Hu, Yu, Zhu, Qingqing, Li, Ruibin, Liu, Qian, Liu, Sijin, Liao, Chunyang, Jiang, Guibin. Nanoscale Zinc-Based Metal-Organic Frameworks Induce Neurotoxicity by Disturbing the Metabolism of Catecholamine Neurotransmitters. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2023, 57(3): 5380-5390, http://dx.doi.org/10.1021/acs.est.2c09740.
[3] Huang, Xiaofeng, Yang, Renjun, Qi, Zijuan, Wang, Xudong, Yin, Nuoya, Faiola, Francesco, Liu, Sijin, Gao, Ming. Downregulation of m(6)A demethylase ALKBH5 promotes AuNP-induced neural stem cell quiescence via regulating ID4 expression. ENVIRONMENTAL SCIENCE-NANO[J]. 2023, 10(3): 843-854, http://dx.doi.org/10.1039/d2en00734g.
[4] Xu, Lining, Xu, Ming, Sun, Xing, Feliu, Neus, Feng, Liuxing, Parak, Wolfgang J, Liu, Sijin. Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based Targeting. ACS Nano[J]. 2023, 17(3): 2039-2052, http://dx.doi.org/10.1021/acsnano.2c07295.
[5] Qi, Yu, Chen, Yucai, Yan, Xu, Liu, Wei, Ma, Li, Liu, Yongchun, Ma, Qingxin, Liu, Sijin. Co-Exposure of Ambient Particulate Matter and Airborne Transmission Pathogens: The Impairment of the Upper Respiratory Systems. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2022, 56(22): 1-10, http://dx.doi.org/10.1021/acs.est.2c03856.
[6] Zhu, Jianqiang, Fu, Qingfeng, Wang, Shunhao, Ren, Liting, Feng, Wenya, Wei, Shuting, Zhang, Zhihong, Xu, Yong, Ganz, Tomas, Liu, Sijin. Palladium Nanoplate-Based IL-6 Receptor Antagonists Ameliorate Cancer-Related Anemia and Simultaneously Inhibit Cancer Progression. NANO LETTERS[J]. 2022, 22(2): 751-760, http://dx.doi.org/10.1021/acs.nanolett.1c04260.
[7] Gao, Ming, Qi, Zijuan, Deng, Min, Huang, Hongyang, Xu, Zhijie, Guo, Guijie, Jing, Jiajun, Huang, Xiaofeng, Xu, Ming, Kloeber, Jake A, Liu, Sijin, Huang, Jinzhou, Lou, Zhenkun, Han, Jinxiang. The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1. ONCOGENE[J]. 2022, 41(33): 4018-4027, http://dx.doi.org/10.1038/s41388-022-02403-w.
[8] Bai, Xuan, Lam, Sin Man, Nie, Pengcheng, Xu, Ming, Liu, Sijin, Shui, Guanghou, Hu, Guoqing. Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant. ENVIRONMENTAL SCIENCE-NANO[J]. 2022, 9(11): 4150-4161, http://dx.doi.org/10.1039/d2en00653g.
[9] Feng, Wenya, Qi, Zijuan, Dong, Zheng, Liu, Wei, Xu, Ming, Gao, Ming, Liu, Sijin. LncRNA MT1DP promotes cadmium-induced DNA replication stress by inhibiting chromatin recruitment of SMARCAL1. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2022, 807: http://dx.doi.org/10.1016/j.scitotenv.2021.151078.
[10] Liu, Wei, Wu, Yue, Zhang, Na, Liu, Sijin, Zhou, Li. Disordered Maternal and Fetal Iron Metabolism Occurs in Preterm Births in Human. DISEASE MARKERS[J]. 2022, 2022: http://dx.doi.org/10.1155/2022/1664474.
[11] Li, Yifan, Zhu, Qingqing, Bi, Shihao, Zhou, Qunfang, Liang, Yong, Liu, Sijin, Liao, Chunyang. Associations between concentrations of typical ultraviolet filter benzophenones in indoor dust and human hair from China: A human exposure study. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2022, 841: [12] Wang, Weichao, Liu, Xian, Zhang, Changwen, Sheng, Fei, Song, Shanjun, Li, Penghui, Dai, Shaoqing, Wang, Bin, Lu, Dawei, Zhang, Luyao, Yang, Xuezhi, Zhang, Zhihong, Liu, Sijin, Zhang, Aiqian, Liu, Qian, Jiang, Guibin. Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning. CHEMICAL SCIENCE[J]. 2022, 13(6): 1648-1656, http://dx.doi.org/10.1039/d1sc06156a.
[13] Gao, Ming, Qi, Zijuan, Feng, Wenya, Huang, Hongyang, Xu, Zhijie, Dong, Zheng, Xu, Ming, Han, Jinxiang, Kloeber, Jake A, Huang, Jinzhou, Lou, Zhenkun, Liu, Sijin. m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2022, 298(2): http://dx.doi.org/10.1016/j.jbc.2022.101563.
[14] Qi, Zijuan, Huang, Xiaofeng, Feng, Wenya, Dong, Zheng, Xu, Ming, Cui, Yazhou, Xia, Tian, Liu, Sijin, Gao, Ming, Han, Jinxiang. Significance of m6A regulation in environmental health and safety (EHS) assessment: MWCNTs induced pulmonary toxicity through m6A modifications of mitophagy-related genes. NANO TODAY[J]. 2022, 46: http://dx.doi.org/10.1016/j.nantod.2022.101624.
[15] Qin, Xinyi, Zhuang, Yuan, Ma, Juan, Liu, Sijin, Shi, Baoyou. Enhanced toxicity effects of iron particles together with PFOA in drinking water. ENVIRONMENTAL POLLUTION[J]. 2022, 311: http://dx.doi.org/10.1016/j.envpol.2022.119919.
[16] Yan, Xu, Qi, Yu, Ren, Liting, Ma, Juan, Xu, Ming, Xia, Tian, Liu, Sijin. Silver nanoclusters show advantages in macrophage tracing in vivo and modulation of anti-tumor immuno-microenvironment. JOURNAL OF CONTROLLED RELEASE[J]. 2022, 348: 470-482, http://dx.doi.org/10.1016/j.jconrel.2022.06.006.
[17] Su, Yu, Hu, Xi, Tang, Hongjie, Lu, Kun, Li, Huimin, Liu, Sijin, Xing, Baoshan, Ji, Rong. Steam disinfection releases micro(nano)plastics from silicone-rubber baby teats as examined by optical photothermal infrared microspectroscopy (vol 17, pg 76, 2022). NATURE NANOTECHNOLOGYnull. 2022, 17(6): 672-672, http://dx.doi.org/10.1038/s41565-022-01155-8.
[18] Qi, Yu, Chen, Yucai, Xia, Tian, Lynch, Iseult, Liu, Sijin. Extra-Pulmonary Translocation of Exogenous Ambient Nanoparticles in the Human Body. ACS NANO[J]. 2022, 17(1): 1-8, http://dx.doi.org/10.1021/acsnano.2c09299.
[19] 王煦栋, 刘思金, 徐明. 地下水铀污染与饮用水中铀的健康风险. 环境化学[J]. 2021, 40(6): 1631-1642, http://hjhx.rcees.ac.cn/article/doi/10.7524/j.issn.0254-6108.2021021804.
[20] Hu, Shiqi, Jiang, Haiping, Zhu, Jianqiang, Wang, Jinqiang, Wang, Shunhao, Tang, Jianbin, Zhou, Zhuxian, Liu, Sijin, Shen, Youqing. Tumor-specific fluorescence activation of rhodamine isothiocyanate derivatives. JOURNAL OF CONTROLLED RELEASE[J]. 2021, 330: 842-850, http://dx.doi.org/10.1016/j.jconrel.2020.10.057.
[21] Liu, Shuyu, Yang, Renjun, Chen, Yongjiu, Zhao, Xingchen, Chen, Shaokun, Yang, Xuezhi, Cheng, Zhanwen, Hu, Bowen, Liang, Xiaoxing, Yin, Nuoya, Liu, Qian, Wang, Hailin, Liu, Sijin, Faiola, Francesco. Development of Human Lung Induction Models for Air Pollutants' Toxicity Assessment. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2021, 55(4): 2440-2451, https://www.webofscience.com/wos/woscc/full-record/WOS:000620926800025.
[22] Wei, Shuting, Liu, Wei, Qi, Yu, Guo, Yifan, Zhang, Shuping, Wang, Li, Zhuang, Taifeng, Zhang, Na, Liu, Sijin. Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans. BRITISH JOURNAL OF HAEMATOLOGY[J]. 2021, 192(3): 643-651, http://dx.doi.org/10.1111/bjh.17049.
[23] Sang, Chen, Song, Yu, Jin, Tongwang, Zhang, Shuo, Fu, Linyan, Zhao, Yi, Zou, Xinxin, Wang, Zhe, Gao, Hui, Liu, Sijin. Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-alpha pathways. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH[J]. 2021, 28(27): 36060-36068, http://dx.doi.org/10.1007/s11356-021-13267-0.
[24] Qi, Yu, Yan, Xu, Xia, Tian, Liu, Sijin. Use of macrophage as a Trojan horse for cancer nanotheranostics. MATERIALS & DESIGN[J]. 2021, 198: https://doaj.org/article/2b6ab2f9300b41249f757477fabb4550.
[25] Sijin Liu. Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways. Environ Sci Pollut Res Int .. 2021, [26] SanchezCano, Carlos, AlvarezPuebla, Ramon A, Abendroth, John M, Beck, Tobias, Blick, Robert, Cao, Yuan, Caruso, Frank, Chakraborty, Indranath, Chapman, Henry N, Chen, Chunying, Cohen, Bruce E, Conceicao, Andre L C, Cormode, David P, Cui, Daxiang, Dawson, Kenneth A, Falkenberg, Gerald, Fan, Chunhai, Feliu, Neus, Gao, Mingyuan, Gargioni, Elisabetta, Glueer, ClausC, Gruener, Florian, Hassan, Moustapha, Hu, Yong, Huang, Yalan, Huber, Samuel, Huse, Nils, Kang, Yanan, Khademhosseini, Ali, Keller, Thomas F, Koernig, Christian, Kotov, Nicholas A, Koziej, Dorota, Liang, XingJie, Liu, Beibei, Liu, Sijin, Liu, Yang, Liu, Ziyao, LizMarzan, Luis M, Ma, Xiaowei, Machicote, Andres, Maison, Wolfgang, Mancuso, Adrian P, Megahed, Saad, Nickel, Bert, Otto, Ferdinand, Palencia, Cristina, Pascarelli, Sakura, Pearson, Arwen, PenateMedina, Oula, Qi, Bing, Raedler, Joachim, Richardson, Joseph J, Rosenhahn, Axel, Rothkamm, Kai, Rubhausen, Michael, Sanyal, Milan K, Schaak, Raymond E, Schlemmer, HeinzPeter, Schmidt, Marius, Schmutzler, Oliver, Schotten, Theo, Schulz, Florian, Sood, A K, Spiers, Kathryn M, Staufer, Theresa, Stemer, Dominik M, Stierle, Andreas, Sun, Xing, Tsakanova, Gohar, Weiss, Paul S, Weller, Horst, Westermeier, Fabian, Xu, Ming, Yan, Huijie, Zeng, Yuan, Zhao, Ying, Zhao, Yuliang, Zhu, Dingcheng, Zhu, Ying, Parak, Wolfgang J. X-ray-Based Techniques to Study the Nano-Bio Interface. ACS NANOnull. 2021, 15(3): 3754-3807, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992135/.
[27] Gao, Jia, Liao, Chunyang, Liu, Sijin, Xia, Tian, Jiang, Guibin. Nanotechnology: new opportunities for the development of patch-clamps. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2021, 19(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017657/.
[28] Liu, Xinlei, Ma, Juan, Ji, Rong, Wang, Songfeng, Zhang, Qiurong, Zhang, Chengdong, Liu, Sijin, Chen, Wei. Biochar Fine Particles Enhance Uptake of Benzo(a)pyrene to Macrophages and Epithelial Cells via Different Mechanisms. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS[J]. 2021, 8(3): 218-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000629145800005.
[29] Zhang, Jie, Liu, Sijin, Han, Jinxiang, Wang, Zhe, Zhang, Shuping. On the developmental toxicity of silver nanoparticles. MATERIALS & DESIGN[J]. 2021, 203: http://dx.doi.org/10.1016/j.matdes.2021.109611.
[30] Ma, Juan, Liu, Xinlei, Yang, Yi, Qiu, Jiahuang, Dong, Zheng, Ren, Quanzhong, Zuo, Yi Y, Xia, Tian, Chen, Wei, Liu, Sijin. Binding of Benzoapyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy. ACS NANO[J]. 2021, 15(6): 9717-9731, http://dx.doi.org/10.1021/acsnano.1c00324.
[31] Wang, Lixin, Wang, Yingxue, Xu, Man, Ma, Juan, Zhang, Shuping, Liu, Sijin, Wang, Ke, Tian, Huifang, Cui, Jiansheng. Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid*. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 410: http://dx.doi.org/10.1016/j.jhazmat.2020.124536.
[32] Zheng, Huizhen, Jiang, Jun, Xu, Shujuan, Liu, Wei, Xie, Qianqian, Cai, Xiaoming, Zhang, Jie, Liu, Sijin, Li, Ruibin. Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications. NANOSCALEnull. 2021, 13(4): 2266-2285, http://dx.doi.org/10.1039/d0nr08478f.
[33] Zhao, Chao, Xie, Peisi, Yong, Ting, Huang, Wei, Liu, Jianjun, Wu, Desheng, Ji, Fenfen, Li, Min, Zhang, Doudou, Li, Ruijin, Dong, Chuan, Ma, Juan, Dong, Zheng, Liu, Sijin, Cai, Zongwei. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. SCIENCE BULLETIN[J]. 2021, 66(6): 578-591, [34] Liao, Chunyang, Liu, Sijin. Tuning the physicochemical properties of reticular covalent organic frameworks (COFs) for biomedical applications. JOURNAL OF MATERIALS CHEMISTRY Bnull. 2021, 9(31): 6116-6128, http://dx.doi.org/10.1039/d1tb01124c.
[35] Xu, Lining, Xu, Ming, Wang, Ruixia, Yin, Yongguang, Lynch, Iseult, Liu, Sijin. The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials. SMALL[J]. 2020, 16(36): 2003691-, https://www.webofscience.com/wos/woscc/full-record/WOS:000558056100001.
[36] Wang, Shunhao, Qiu, Jiahuang, Guo, Anyi, Ren, Ruanzhong, He, Wei, Liu, Sijin, Liu, Yajun. Nanoscale perfluorocarbon expediates bone fracture healing through selectively activating osteoblastic differentiation and functions. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2020, 18(1): http://dx.doi.org/10.1186/s12951-020-00641-2.
[37] Yu Qi, Tong Zhang, Chuanyong Jing, Sijin Liu, Chengdong Zhang, Pedro J J Alvarez, Wei Chen. Nanocrystal facet modulation to enhance transferrin binding and cellular delivery. NATURE COMMUNICATIONS[J]. 2020, 11(1): 1-10, http://dx.doi.org/10.1038/s41467-020-14972-z.
[38] Chen, Yongjiu, Ma, Juan, Xu, Ming, Liu, Sijin. Antiviral nanoagents: More attention and effort needed?. NANO TODAY[J]. 2020, 35: 100976-, http://dx.doi.org/10.1016/j.nantod.2020.100976.
[39] Ma, Minghao, Wang, Ruixia, Xu, Lining, Xu, Ming, Liu, Sijin. Emerging health risks and underlying toxicological mechanisms of uranium contamination: Lessons from the past two decades. ENVIRONMENT INTERNATIONAL[J]. 2020, 145: 106107-, http://dx.doi.org/10.1016/j.envint.2020.106107.
[40] Chen, Shaopeng, Chen, Wei, Liu, Sijin. Continuous efforts to understand the environmental health and safety (EHS) of nanomaterials for safer applications. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2020, 202: http://dx.doi.org/10.1016/j.ecoenv.2020.110894.
[41] Yang, Qiuyuan, Liu, Wei, Zhang, Shuping, Liu, Sijin. The cardinal roles of ferroportin and its partners in controlling cellular iron in and out. LIFE SCIENCESnull. 2020, 258: http://dx.doi.org/10.1016/j.lfs.2020.118135.
[42] Wang, Zhe, Li, Qingqing, Xu, Lining, Ma, Juan, Wei, Bing, An, Zhen, Wu, Weidong, Liu, Sijin. Silver nanoparticles compromise the development of mouse pubertal mammary glands through disrupting internal estrogen signaling. NANOTOXICOLOGY[J]. 2020, 14(6): 740-756, http://dx.doi.org/10.1080/17435390.2020.1755470.
[43] Ma, Juan, He, Peng, Zhao, Chuanfang, Ren, Quanzhong, Dong, Zheng, Qiu, Jiahuang, Jing, Yang, Liu, Sijin, Du, Yuguo. A Designed alpha-GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d-iNKT Axis and CD11b-Positive Monocytes/Macrophages. ADVANCED SCIENCE[J]. 2020, 7(14): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000538605200001.
[44] Liu, Sijin, Xia, Tian. Continued Efforts on Nanomaterial-Environmental Health and Safety Is Critical to Maintain Sustainable Growth of Nanoindustry. SMALLnull. 2020, 16(21): http://dx.doi.org/10.1002/smll.202000603.
[45] Ren, Liting, Feng, Wenya, Shao, Jie, Ma, Juan, Xu, Ming, Zhu, BenZhan, Zheng, Nanfeng, Liu, Sijin. Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting. THERANOSTICS[J]. 2020, 10(14): 6384-6398, http://dx.doi.org/10.7150/thno.45558.
[46] Wang, Zhe, Li, Qingqing, Xu, Lining, Ma, Juan, Wang, Yan, Wei, Bing, Wu, Weidong, Liu, Sijin. Ageing alters the physicochemical properties of silver nanoparticles and consequently compromises their acute toxicity in mammals. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2020, 196: http://dx.doi.org/10.1016/j.ecoenv.2020.110487.
[47] 徐明, 阚海东, 桑楠, 刘思金. 持久性有毒污染物环境健康研究的现状与思考. 中国科学院院刊[J]. 2020, 35(11): 1337-1343, http://lib.cqvip.com/Qikan/Article/Detail?id=7103383614.
[48] Wu, Yakun, Feng, Wenya, Liu, Rui, Xia, Tian, Liu, Sijin. Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver. ACS NANO[J]. 2020, 14(1): 877-890, http://dx.doi.org/10.1021/acsnano.9b08127.
[49] Qiu, Jiahuang, Ma, Juan, Zhang, Shuping, Han, Jinxiang, Liu, Sijin. Promoting platelets is a therapeutic option to combat severe viral infection of the lung. BLOOD ADVANCES. 2020, 4(8): 1640-1642, http://dx.doi.org/10.1182/bloodadvances.2020001669.
[50] Liu, Wei, Zhang, Shuping, Nekhai, Sergei, Liu, Sijin. Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival. CURRENT CLINICAL MICROBIOLOGY REPORTS[J]. 2020, 7(2): 13-19, http://dx.doi.org/10.1007/s40588-020-00140-w.
[51] Guo, Yifan, Li, Bin, Yan, Xu, Shen, Xinming, Ma, Juan, Liu, Sijin, Zhang, Daoqiang. Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. CHEMOSPHERE[J]. 2020, 246: http://dx.doi.org/10.1016/j.chemosphere.2019.125775.
[52] Shujuan Xu, Huizhen Zheng, Ronglin Ma, Di Wu, Yanxia Pan, Chunyang Yin, Meng Gao, Weili Wang, Wei Li, Sijin Liu, Zhifang Chai, Ruibin Li. Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death. NATURE COMMUNICATIONS[J]. 2020, 11(1): 1-14, https://doaj.org/article/e4b1da3323cd4276b0d143ad62458143.
[53] Bai, Xue, Wang, Shenqing, Yan, Xiliang, Zhou, Hongyu, Zhan, Jinhua, Liu, Sijin, Sharma, Virender K, Jiang, Guibin, Zhu, Hao, Yan, Bing. Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries. ACS NANO[J]. 2020, 14(1): 289-302, https://www.webofscience.com/wos/woscc/full-record/WOS:000510531500022.
[54] Gao, Ming, Dong, Zheng, Sun, Jinfang, Liu, Wei, Xu, Ming, Li, Changying, Zhu, Pan, Yang, Xingfeng, Shang, Xiaohong, Wu, Yongning, Liu, Sijin. Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity. ENVIRONMENTAL POLLUTION[J]. 2020, 258: 113717-, http://dx.doi.org/10.1016/j.envpol.2019.113717.
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[191] Zhang, Shuping, Chen, Yue, Guo, Wenli, Yuan, Lin, Zhang, Daoqiang, Xu, Yong, Nemeth, Elizabeta, Ganz, Tomas, Liu, Sijin. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. CELLULAR SIGNALLING[J]. 2014, 26(11): 2539-2550, http://dx.doi.org/10.1016/j.cellsig.2014.07.029.
[192] Sun, Li, Guo, Wenli, Yin, Chunyang, Zhang, Shuping, Qu, Guangbo, Hou, Yanli, Rong, Haiqin, Ji, Hong, Liu, Sijin. Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. GENE[J]. 2014, 543(1): 161-165, http://dx.doi.org/10.1016/j.gene.2014.02.023.
[193] Li, Junping, Hou, Yanli, Zhang, Shuping, Ji, Hong, Rong, Haiqin, Qu, Guangbo, Liu, Sijin. Excess iron undermined bone load-bearing capacity through tumor necrosis factor-alpha-dependent osteoclastic activation in mice. BIOMEDICAL REPORTS[J]. 2013, 1(1): 85-88, [194] Chen, Liqun, Qu, Guangbo, Sun, Xue, Zhang, Shuping, Wang, Lei, Sang, Nan, Du, Yuguo, Liu, Jun, Liu, Sijin. Characterization of the Interaction between Cadmium and Chlorpyrifos with Integrative Techniques in Incurring Synergistic Hepatoxicity. PLOS ONE[J]. 2013, 8(3): https://doaj.org/article/d3d5d2d2e23e4525a4cd733a669dbdfb.
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[196] Wang, Lei, Zhang, Shuping, Lin, Ronghai, Li, Long, Zhang, Daoqiang, Li, Xinghong, Liu, Sijin. PCB-77 disturbs iron homeostasis through regulating hepcidin gene expression. GENE[J]. 2013, 532(1): 146-151, http://dx.doi.org/10.1016/j.gene.2013.09.023.
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[198] Wang, Lixin, Wang, Xiaoyan, Zhang, Shuping, Qu, Guangbo, Liu, Sijin. A protective role of heme-regulated eIF2 alpha kinase in cadmium-induced toxicity in erythroid cells. FOOD AND CHEMICAL TOXICOLOGY[J]. 2013, 62: 880-891, http://www.irgrid.ac.cn/handle/1471x/844359.
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[203] 李君平, 季虹, 侯艳丽, 张书平, 刘思金, 荣海钦. 绝经后骨质疏松小鼠模型肝脏铁调素表达增加. 中国骨质疏松杂志[J]. 2013, 6(1): 547-551, http://www.irgrid.ac.cn/handle/1471x/930121.
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（ 1 ） 典型有机磷农药和重金属的联合毒性效应与作用机理, 主持, 国家级, 2011-01--2013-12
（ 2 ） 持久性有机污染物的分子毒理学研究, 主持, 部委级, 2009-09--2013-12
（ 3 ） 多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的影响及相关分子机制的研究, 主持, 国家级, 2011-01--2013-12
（ 4 ） 纳米银的胚胎发育毒性机理研究, 主持, 国家级, 2012-01--2015-12
（ 5 ） 人工纳米材料环境效应的分子作用机制研究, 主持, 国家级, 2014-01--2018-12
（ 6 ） 典型污染物对肿瘤细胞增殖与转移的影响机制, 主持, 部委级, 2014-07--2019-06
（ 7 ） 环境污染物的毒理与健康效应, 主持, 国家级, 2015-01--2018-12
（ 8 ） 高环境暴露风险金属纳米材料的胚胎发育毒性, 主持, 国家级, 2017-01--2021-12
（ 9 ） 大气细颗粒物肺内转化对其毒性的影响机制, 主持, 国家级, 2020-01--2024-12
（ 10 ） 大气细颗粒物与肺内生物分子的相互作用及损伤机制, 主持, 部委级, 2020-01--2022-12

（1）Biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and in vitro and in vivo bio-interactions    第255届美国化学会年会   2018-08-23
（2）Molybdenum disulfide (MoS2)/graphene oxide (GO) nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with desirable biocompatibility    第255届美国化学会年会   2018-08-22
（3）重金属等污染物的毒性靶点识别与毒性通路    2018环境与健康学术会议   2018-08-14
（4）重金属等污染物的毒性靶点识别与毒性通路    2018环境与健康学术会议   2018-08-14
（5）石墨烯的毒性机制与转化毒理研究    第二届全国环境纳米技术及生物效应学术研讨会（2018）   2018-06-18
（6）石墨烯的毒性机制与转化毒理研究    第二届全国环境纳米技术及生物效应学术研讨会（2018）   2018-06-18
（7）Silver nanoparticles repress hemoglobin transcription through an epigenetic mechanism: altering the methylation status of histone 3   2015-12-15
（8）Environmental pollutants, iron metabolism, and cancer risk   2015-11-15
（9）Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells   2013-08-12

已指导学生

张书平  博士研究生  083001-环境科学  

王立新  博士研究生  083001-环境科学  

王哲  博士研究生  083001-环境科学  

王雷  硕士研究生  430130-环境工程  

王小岩  博士研究生  083001-环境科学  

郭文丽  博士研究生  083001-环境科学  

刘静  博士研究生  083001-环境科学  

张洁  博士研究生  083001-环境科学  

高婕  硕士研究生  083001-环境科学  

马娟  博士研究生  083001-环境科学  

吴亚坤  博士研究生  083001-环境科学  

陈禹男  硕士研究生  077601-环境科学  

尹春阳  博士研究生  070303-有机化学  

陈永久  博士研究生  083001-环境科学  

汪顺浩  博士研究生  070303-有机化学  

申心铭  硕士研究生  085238-生物工程  

任泉仲  硕士研究生  077601-环境科学  

现指导学生

杨秋源  博士研究生  083001-环境科学  

刘伟  博士研究生  083001-环境科学  

闫旭  博士研究生  083001-环境科学  

冯文雅  博士研究生  070303-有机化学  

王瑞霞  博士研究生  083001-环境科学  

丘嘉煌  博士研究生  083001-环境科学  

徐立宁  博士研究生  083001-环境科学  

陈誉才  硕士研究生  086000-生物与医药  

董政  博士研究生  083001-环境科学