1. Immune responses and immune memory characteristics upon infection or cancer

2. Immune repertoire profiling

3. Aging B/T cell repertoire analysis

2012.09-2017.06, University of Toronto, Ph.D.

2017.11 - 2022.06, Stanford University, Postdoctoral Fellow

2015.09 - 2017. 06, Whole-Genome Sequencing and Analysis Laboratory

   

1.     Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues

Fan Yang^#, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Röltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J.L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Rober S. Ohgami, Kari C. Nadeau, Eleanor L. Marshall, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd^#. Science, 2021. 372(6543): p. 738.

Highlighted in Faculty Opinions by Dr. Maria C. Castells (Director of Drug Hypersensitivity and Desensitization Center, Director of Mastocytosis Center, Professor of Harvard Medical School), 19 May 2021; 10.3410/f.739921164.793585681

2.     Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

Sandra C. A. Nielsen*, Fan Yang*, Katherine J. L. Jackson*, Ramona A. Hoh*, Katharina Röltgen, Bryan Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J. Rogers, Abigail E. Powell, Javaria Najeeb, Ana R. Otrelo-Cardoso, Kathryn E. Yost, Bence Daniel, Howard Y. Chang, Ansuman T. Satpathy, Theodore S. Jardetzky, Peter S. Kim, Taia T. Wang, Benjamin A. Pinsky, Catherine A. Blish^#, Scott D. Boyd^#, Cell Host & Microbe, 2020 October 7, 28(4) 516-525.e5.

3.     Quantifying Immune-Based Counterselection of Somatic Mutations

Fan Yang, Dae-Kyum Kim, Hidewaki Nakagawa, Seiya Imoto, Lincoln Stein and Frederick P. Roth,

PLoS Genetics, 2019 July, 15(7): e1008227.

4.     Identifying pathogenicity of human variants via paralog-based yeast complementation

Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E. Hill, Marc Vidal, Brenda J. Andrews, Charles Boone, Frederick P. Roth, PLoS Genetics, 2017 May, 13(5), e1006779.

5.     Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations

Fan Yang, Evangelia Petsalaki, Thomas Rolland, David E. Hill, Marc Vidal and Frederick P. Roth,

PLoS Computational Biology, 2015 Mar, 11(3): e1004147. DOI: 10.1371/journal.pcbi.1004147