基本信息
刘双江 男 博导 微生物研究所
电子邮件:liusj@im.ac.cn
通信地址:北京市朝阳区北辰西路1号院3号
邮政编码:100101

研究领域

环境微生物学课题组以芳烃化合物的微生物转化与降解、极端酸热条件下硫磺的微生物转化和特定环境中微生物多样性与生物修复技术等为研究内容,开展微生物与环境的相互关系研究,以及基于微生物学理论的环境生物技术研究和合成生物学研究,包括:(1)难降解有机污染物的微生物代谢调控和趋化机理的研究;(2)特定区域环境的微生物种群和物质转化;(3)莽草酸代谢的合成生物学。

招生信息

   
招生专业
071005-微生物学
071010-生物化学与分子生物学
招生方向
生物冶金微生物生理及遗传,芳烃污染物的微生物降解及代谢
微生物的代谢与应用

教育背景

1987-09--1991-02 清华大学环境工程系 工学博士
1984-09--1987-07 浙江农业大学环境保护系 农学硕士
1980-09--1984-07 河北大学生物系 理学学士
学历
-- 研究生
学位
-- 博士
出国学习工作
1998-05--2001-02 德国明斯特大学微生物研究所 高级访问学者
1997-04--1998-04 美国James Madison 大学生物系 博士后
1996-03--1997-03 日本通产省工业技术研究院(AIST)国立生命工学研究所 AIST学者/高级访问学者
1995-06--1996-02 德国明斯特大学微生物研究所 访问学者

教授课程

微生物生态学、 污染物质归趋与生态毒理学

出版信息

   
发表论文
(1) Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway,AMB Express,2015,通讯作者
(2) A novel chemoreceptor MCP2983 from Comamonas testosteroni specifically binds to cis-aconitate and triggers chemotaxis towards diverse organic compounds,Applied Microbiology and Biotechnology,2015,通讯作者
(3) Metallosphaera tengchongensis sp. nov., a novel species of acidothermophilic archaeon isolated from a hot spring,International Journal of Systematic and Evolutionary Microbiology,2014,通讯作者
(4) Thiosulfate Transfer Mediated by DsrE/TusA Homologs from Acidothermophilic Sulfur-oxidizing Archaeon Metallosphaera cuprina, Journal of biological chemistry,2014,通讯作者
(5) Resolution of carbon metabolism and sulfur-oxidation pathways of Metallosphaera cuprina Ar-4 via comparative proteomics,Journal of proteomics,2014,通讯作者
(6) Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress,Chinese Science Bulletin,2014,通讯作者
(7) Genetic characterization of 4-cresol catabolism in Corynebacterium glutamicum,Journal of Biotechnology,2014,通讯作者
(8) Bacterial chemotaxis on SlipChip,Lab on a Chip,2014,通讯作者
(9) Benzoate Metabolism Intermediate Benzoyl Coenzyme A AffectsGentisate Pathway Regulation in Comamonas testosteroni,Applied and Environmental Microbiology,2014,通讯作者
(10) Metabolic flux response to genetic modification for shikimic acid production by Bacillus subtilis strains,Microbial Cell Factories,2014,通讯作者
(11) Clostridium algifaecis sp. nov., an anaerobic bacterial species from decomposing algal scum,International Journal of Systematic and Evolutionary Microbiology,2014,通讯作者
(12) Construction and application of an expression vector from the new plasmid pLAtc1 of Acidithiobacillus caldus,Applied Microbiology and Biotechnology,2014,通讯作者
(13) Consumers of 4-chloro-2-methylphenoxyacetic acid from agricultural soil and drilosphere harbor cadA, rlsdpA, and tfdA-like gene encoding oxygenases,FEMS Microbiol Ecology,2013,通讯作者
(14) 环境微生物培养新技术的研究进展,微生物学通报,2013,通讯作者
(15) Proteomic and molecular investigations revealed that Acidithiobacillus caldus adopts multiple strategies for adaptation to NaCl stress,Chinese Science Bulletin,2013,通讯作者
(16) Parapedobacter pyrenivorans sp. nov., isolated from a pyrene-degrading microbial enrichment, and emended description of the genus Parapedobacter,International Journal of Systematic and Evolutionary Microbiology, 63, 3994–3999.,2013,通讯作者
(17) Chryseobacterium taihuense sp. nov., isolated from a eutrophic lake, and emended descriptions of the genus Chryseobacterium, Chryseobacterium taiwanense, Chryseobacterium jejuense and Chryseobacterium indoltheticum,International Journal of Systematic and Evolutionary Microbiology, 63, 913–919.,2013,通讯作者
(18) Interaction between DAHP synthase and chorismate mutase endows new regulation on DAHP synthase activity in Corynebacterium glutamicum,Appl Microbiol Biotechnol, 97( 24), 10373-10380,2013,通讯作者
(19) Assimilation of aromatic compounds by Comamonas testosteroni: characterization and spreadability of protocatechuate 4,5-cleavage pathway in bacteria,Appl Microbiol Biotechnol.,97:6031–6041.,2013,通讯作者
(20) Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor,Acta Crystallogr D Biol Crystallogr, 69:32-43.,2013,通讯作者
(21) Undibacterium terreum sp. nov., isolated from permafrost soil,International Journal of Systematic and Evolutionary Microbiology, 63, 2296–2300.,2013,通讯作者
(22) Paenibacillus taihuensis sp. Nov., isolated from an eutrophic lake,International Journal of Systematic and Evolutionary Microbiology,2013,通讯作者
(23) Comamonas testosteroni uses a chemoreceptor for tricarboxylic acid cycle intermediates to trigger chemotactic responses towards aromatic compounds,Molecular Microbiology,90(4), 813–823.,2013,通讯作者
(24) Identification and characterization of g-aminobutyric acid uptake system GabPCg (NCgl0464) in Corynebacterium glutamicum,Applied and Environmental Microbiology, 78: 6009-6016.,2012,通讯作者
(25) Deinococcus reticulitermitis sp. nov., isolated from a termite gut, International Journal of Systematic and Evolutionary Microbiology, 62: 78-83.,2012,通讯作者
(26) Augmentation of tribenuron methyl removal from polluted soil with Bacillus sp. strain BS2 and indigenous earthworms,Journal of Environmental Sciencens-China, 24(8) 1492–1497.,2012,通讯作者
(27) Biodegradation of tribenuron methyl that is mediated by microbial acidohydrolysis at cell-soil interface,Chemosphere, 86:1098-1105.,2012,通讯作者
(28) Complete Genome Sequence of Metallosphaera cuprina, a metal sulfide -oxidizing Archaeon from a hot spring,Journal of Bacteriology, 193:3387-3388.,2011,通讯作者
(29) The ncgl1108 (PhePCg) gene encodes a new L-Phe transporter in Corynebacterium glutamicum,Applied Microbiology and Biotechnology, 90(6):2005-13.,2011,通讯作者
(30) Conserved residues in the aromatic acid/H+ symporter family are important for benzoate uptake by NCgl2325 in Corynebacterium glutamicum,International Biodeterioration and Biodegradation, 65: 527-532.,2011,第3作者
(31) Crystal Structures of the Transcriptional Repressor RolRReveals a Novel Recognition Mechanism betweenInducer and Regulator,PLoS ONE, 6(5):e19529.,2011,通讯作者
(32) The earthworm Aporrectodea caliginosa stimulates abundance and activity of phenoxyalkanoic acid herbicide degraders,The ISME Journal, 5: 473-485.,2011,第3作者
(33) Phycicoccus cremeus sp. nov., isolated from forest soil, and emended description of the genus Phycicoccus,International Journal of Systematic and Evolutionary Microbiology, 61(1):71-5.,2011,通讯作者
(34) Untraveling the Acidithiobacillus caldus complete genome andits central metabolisms for carbon assimilation,Journal of Genetics and Genomics, 38:243-252.,2011,通讯作者
(35) Alphaproteobacteria dominate active 2-methyl-4-chlorophenoxyacetic acid herbicide degraders in agricultural soil and drilosphereemi_2405,Environmental Microbiology, 14(4):991-1009.,2011,第2作者
(36) Frateuria terrea sp. nov., isolated from forest soil, and emended description of the genus Frateuria,International Journal of Systematic and Evolutionary Microbiology, 61: 443–447.,2011,通讯作者
(37) Genomic analysis of Acidianus hospitalis W1 a host for studying crenarcha- eal virus and plasmid life cycles,Extremophiles, 15:487-497.,2011,通讯作者
(38) Abundance of Novel and Diverse tfdA-like Genes Encoding Putative Phenoxyalkanoic Acid Herbicide-Degrading Dioxygenases, in Soil,Applied and Environmental Microbiology, 76: 119-128,2010,第3作者
(39) Sphingomonas changbaiensis sp. nov., isolated from forest soil,International Journal of Systematic and Evolutionary Microbiology, 60: 790 - 795,2010,通讯作者
(40) Environmental Biotechnology in China,Advances in Biochemical Engineering/Biotechnology, 122: 151-188,2010,第1作者
(41) Agrococcus terreus sp. nov. and Micrococcus terreus sp. nov., isolated from forest soil,International Journal of Systematic and Evolutionary Microbiology, 60: 1897 - 1903,2010,通讯作者
(42) Identification and quantification of mycothiol in Actinobacteria by a novel enzymatic method,Applied Microbiology and Biotechnology, 88: 1393-1401,2010,通讯作者
(43) PcaO Positively Regulates pcaHG of the β-Ketoadipate Pathway in Corynebacterium glutamicum,Journal of Bacteriology, 192: 1565-1572,2010,通讯作者
(44) The Complete Genome of Comamonas testosteroni Reveals Its Genetic Adaptations to Changing Environments, Applied and Environmental Microbiology, 75: 6812-6819,2009,通讯作者
(45) Genetic and biochemical identification of the chorismate mutase from Corynebacterium glutamicum,Microbiology-SGM, 155: 3382-3391,2009,通讯作者
(46) Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Cornebacterium glutamicum,Applied Microbiology and Biotechnology, 78: 75-83,2008,通讯作者
(47) Corynebacterium glutamicum contains 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that display novel biochemical features,Applied and Environmental Microbiology, 74: 5497-5503,2008,通讯作者
(48) Plant-microbe association for rhizoremediation of chloronitroaromatic pollutants with Comamonas sp. strain CNB-1,Environmental Microbiology, 9: 465-473,2007,通讯作者
(49) Comparative proteomes of Corynebacterium glutamicum grown on aromatic compounds revealed novel proteins involved in aromatic degradation and a clear link between aromatic catabolism and gluconeogenesis via fructose-1,6-bisphosphatase,Proteomics, 7: 3775-3787,2007,通讯作者
(50) Nucleotide sequence of plasmid pCNB1 from Comamonas sp. strain CNB-1 reveals novel genetic organization and evolution for 4-chloronitrobenzene degradation,Applied and Environmental Microbiology, 7: 4477-4483,2007,通讯作者
(51) A novel deaminase involved in chloronitrobenzene and nitrobenzene degradation in Comamonas sp. strain CNB-1,Journal of Bacteriology, 189: 2677-2682,2007,通讯作者
(52) Novel partial reductive pathway for 4-chloronitrobenzene and nitrobenzene degradation in Comamonas strain CNB-1,Applied and Environmental Microbiology, 72: 1759-1765,2006,通讯作者
发表著作
(1) Microbes and the Enviroment: Perspectives and Challenges,微生物与环境:前景与挑战,科学出版社,2008-06,第1作者

科研活动

   
科研项目
(1) 芘和荧蒽微生物降解菌群的结构解析和降解机理的研究,主持,国家级,2014-01--2017-12
(2) 丛毛单胞菌等对芳环类污染物的趋化、降解及其在生物修复中的作用,主持,国家级,2013-01--2017-12
(3) 功能模块的集成与测试,主持,国家级,2012-01--2016-12
参与会议
(1) Acidithiobacillus caldus: A physiological story starts at its genome,第三届微生物硫代谢研讨会,2012-04,刘双江
(2) Exploring the Sulfur Metabolic Pathways of Acidithiobacillus caldus: What does the Genome tell,微生物硫代谢会议,2009-03,刘双江
(3) Corynebacterium glutamicum systems biology: Contribution to the understanding of aromatic metabolism,中德“微生物与环境学术研讨会”,2007-09,刘双江
(4) Corynebacterium glutamicum systems biology: contribution and implication for degradation and production of aromatic chemicals via greener routes,2007-06,刘双江

指导学生

已指导学生

汪中文  博士研究生  071005-微生物学  

刘磊  博士研究生  071005-微生物学  

冯婕   博士研究生  071005-微生物学  

扈玉婷  博士研究生  071005-微生物学  

杨勇  博士研究生  071005-微生物学  

吴建峰  博士研究生  071005-微生物学  

刘兴宇  博士研究生  071005-微生物学  

沈锡辉  博士研究生  071005-微生物学  

黄燕  博士研究生  071005-微生物学  

崔恒林  博士研究生  071005-微生物学  

陈志伟  博士研究生  071005-微生物学  

张伟  硕士研究生  071005-微生物学  

刘艳阳  硕士研究生  071005-微生物学  

李朝  硕士研究生  071005-微生物学  

张芸  博士研究生  071005-微生物学  

马迎飞  博士研究生  071005-微生物学  

尹雅洁  博士研究生  071005-微生物学  

赵克新  博士研究生  071005-微生物学  

尤晓颜  博士研究生  071005-微生物学  

赵智  博士研究生  071005-微生物学  

刘一倩  博士研究生  071005-微生物学  

刘亚君  博士研究生  071005-微生物学  

张佳月  博士研究生  071005-微生物学  

郭旭  博士研究生  071005-微生物学  

李攀攀  博士研究生  071005-微生物学  

张明江  博士研究生  071005-微生物学  

张英姿  博士研究生  071005-微生物学  

陈栋炜  博士研究生  071005-微生物学  

倪斌  博士研究生  071005-微生物学  

刘丽君  博士研究生  071005-微生物学  

张博  博士研究生  071005-微生物学  

现指导学生

吴瑜凡  博士研究生  071005-微生物学  

汤强  博士研究生  071005-微生物学  

江宝塔·穆哈德斯  硕士研究生  071005-微生物学  

杨兰  硕士研究生  071005-微生物学  

李小静  硕士研究生  071005-微生物学  

何蕴喆  硕士研究生  085238-生物工程  

黄舟  博士研究生  071005-微生物学  

周楠  博士研究生  071005-微生物学  

霍玉文  硕士研究生  085238-生物工程  

汪云浩  硕士研究生  085238-生物工程  

赵建康  博士研究生  071005-微生物学  

黄烨  硕士研究生  085238-生物工程  

王语婧  硕士研究生  071010-生物化学与分子生物学  

朱海珍  博士研究生  071005-微生物学  

工作经历

   
工作简历
2001-03--2013-12 中国科学院微生物研究所 研究员 先后任所长助理、研究中心主任、学术委员会副主任、副所长、所长
1991-03--1995-05 中国科学院微生物研究所 助理研究员、副研究员
社会兼职
2011-02--今 《Applied and Environmental Microbiology》编辑
2009-01--今 《Archives of Microbiology》编辑
2005-01--今 《Microbes and Environments》Associate editor

专利与奖励

   
奖励信息
   
专利成果
(1) 一种生产视紫红质蛋白的方法及其专用菌株,发明,2007,第1作者,专利号:ZL 2003 1 0118295.4
(2) 一种降解对氯硝基苯的睾丸酮丛毛单胞菌及其用途,发明,2007,第1作者,专利号:ZL 2003 1 0114337.7
(3) 2-氨基酚1,6-双加氧酶、其基因及用途,发明,2007,第1作者,专利号:ZL 2003 1 0118812.8
(4) 受对氯硝基苯类化合物污染的环境的生物修复方法,发明,2010,第1作者,专利号:ZL 2006 1 0001778.X
(5) 一种硝基苯硝基还原酶及其编码基因与应用,发明,2008,第1作者,专利号:ZL 2004 1 0102835.4
(6) 一种羟氨苯歧位酶及其编码基因与应用,发明,2008,第1作者,专利号:ZL 2004 1 0102836.9
(7) 一种具有广泛宿主的穿梭表达载体,发明,2014,第1作者,专利号:ZL201210390124.6

合作情况

   
中国科学院微生物研究所研究员个人网页链接
http://www.im.ac.cn/sklmr/index.php/team/index/23