General

Guanghui Liu, Ph.D, Prof.

  Principal Investigator

  National Laboratory of Biomacromolecules, IBP  

  1) Using stem cell to study and treat human disease   

  2) Genetic and molecular bases of healthy aging

  3) Targeted genome editing  

  E-mail:ghliu@ibp.ac.cn, Tel:010-64889970

  Fax:010-64871293, Zip code:100101

Research Areas

1) Using stem cell to study and treat human disease

2) Genetic and molecular bases of healthy aging

3) Targeted genome editing

Education

1997-2002, B.S., Peking University Health Science Center

2002-2007, Ph.D., Institute of Biophysics, Chinese Academy of Sciences


  

Experience

2007-2009, Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009-2011, Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2011-, Professor, Institute of Biophysics, Chinese Academy of Sciences

Honors & Distinctions

2018, Tan Jiazhen prize in life sciences innovation
2018-, President, Chinese Society of Aging Cell Research (CSACR)
2018-, Associate Editor, Stem Cell Research & Therapy (Impact factor 4.9)
2017-, Vice president, Chinese Society of Aging Biology (CSAB)
2017, Second class Beijing Science and Technology Award (first place)
2017, Shulan Medical Prize
2017, Youth Scientist of Chinese Academy of Sciences
2017, CSCB Young Investigator
2017, Gerontology Outstanding Contribution Award
2017-, Editorial board, Cell Stress
2017-, Editorial board, Cell Proliferation
2017-, Editorial board, Life Science Alliance
2016-, Vice president, Chinese Society of Regenerative Cell Biology
2016, Innovative Award of “the capital of ten scientific and technological research and management plan”
2016, National Science Foundation for Distinguished Young Scholars
2015, 973 program chief scientist
2015, Bill and Melinda Gates Foundation Grand Challenges 2015-Young Scientist
2015, CSSCR Stem Cell Young Investigator
2015-, Deputy Editor-in-Chief, Protein & Cell (Impact factor 6.2)
2013, Bei Shi-Zhang Young Scientist Award in Biophysics
2012, Thousand Young Talents program of China
2012, National Science Foundation for Excellent Young Scholars
2011, Glenn Aging Foundation fellowship (in US)
2010, California Institute of Regenerative Medicine (CIRM) scholar training grant (in US)
2007, Award by the president of Chinese Academy of Sciences

Publications

1. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W#, Liu GH#, Hu B#. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018. 560(7720):661-665. (#Corresponding author)

2. Zhang W, Song M, Qu J#, Liu GH#. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circ Res. 2018. 123:773-786. (#Corresponding author)

3. Geng L, Liu Z, Zhang W#, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M#, Qu J#, Liu GH#. Chemical Screen Identifies a GeroprotectiveRole of Quercetin in Premature Aging. Protein Cell. 2018. doi: 10.1007/s13238-018-0567-y. (#Corresponding author)

4. Wang S,Hu B,Ding Z,Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J#, Tang F#, Liu GH#. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018. Jan 5;4:2. (#Corresponding author)

5. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J#, Suzuki K#, Belmonte JC#, Liu GH#. Differential stem cell aging kinetics inHutchinson–Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018. 9(4):333-350.(#Corresponding author)

6. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH#, Wang L#. Metformin alleviates human cellular aging by upregulating the ER peroxidase GPx7. Aging Cell. 2018. 16:e12765.(#Corresponding author)

7. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T#, Qu J#, Liu GH#. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res. 2017. 27(4):483-504. (#Corresponding author)

8. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J#, Tang F#, Liu GH#. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Res. 2017. doi:10.1038/cr.2017 (#Corresponding author)

9. Ren R, Ocampo A, Liu GH#, Belmonte JC#. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017. j.cmet.2017.07.019 (#Corresponding author)  

10. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y#, Qu J#, Liu GH#. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosispatient iPSCs. Protein Cell. 2017. DOI 10.1007/s13238-017-0397-3.( #Corresponding author)

11. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH#, Misteli T#, Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016. 165(6):1361-74 (#Corresponding author

12. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J#, Tang F#, Liu GH#. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016. 26(2):190-205. (#Corresponding author

13. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nu?ez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature. 2016. 540(7631):144-149.

14. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z.SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507

15. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC#, Qu J#, Liu GH#. Modeling Xeroderma Pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell. 2016. 7(3):210-21. (#Corresponding author)

16. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J#, Zhang W#, Liu GH#. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016. 7(7):478-88. (#Corresponding author)

17. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F#, Liu GH#, Belmonte JC#. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015. 348(6239):1160-3. (#Corresponding author

18. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell. 2015. 161:459-469

19. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J#, Tang F#, Liu GH#. PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015. 6:10068. (#Corresponding author

20. Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla R, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH#, Li Y#, Belmonte JC#. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load. Cell Stem Cell. 2014. 15, 31–36. (#Corresponding author)

21. Liu GH#, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Esteban C, Izpisua Belmonte JC#. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs. Nat Commun. 2014. 7;5:4330. (#Corresponding author)

22. Yang J, Cai N, Yi F, Liu GH#, Qu J#, Belmonte JC#. Gating pluripotency via nuclear pores. Trends Mol Med. 2014. 20(1):1-7. (#Corresponding author)

23. Wu K, Ren R, Su W, Wen Bo, Zhang Yuying, Yi Fei, Qiao X, Yuan T, Wang J, Liu L, Belmonte JC#, Liu GH#, Chen C#. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014. 289(29):20193-9. (#Corresponding author)

24. Xu XL#, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K, Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL, Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L, Izpisua Belmonte JC, Liu GH#. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell. 2014. 5(1):4-7. (#Corresponding author)

25. Xu X, Duan S, Yi F, Ocampo A, Liu GH#, Belmonte JC#. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013. 18:325-32. (#Corresponding author)

26. Pan H, Cai N, Li M, Liu GH#, Belmonte JC#. Autophagic control of cell stemness. EMBO Mol. Med. 2013. 5(3):327-31. (#Corresponding author)

27. Zhang WQ, Qu J, Suzuki K, Liu GH#, Belmonte JC#. Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013. 23(12):587-92. (#Corresponding author)

28. Guan D, Zhang W, Zhang W#, Liu GH#, Belmonte JC#. Switching cell fate, ncRNAs coming to play. Cell Death Dis. 2013.17;4:e464. (#Corresponding author)

29. Liu GH#, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R, Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte JC#. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012. 491:603-7. (#Corresponding author)

30. Li M*, Liu GH*, Belmonte JC. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol. 2012; 13(8):524-35. (*equal contribution)

31. Liu GH#, Ding Z, Izpisua Belmonte JC#. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012. 24(6):765-74(#Corresponding author)

32. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012. 109(31):12556-61

33. Liu GH*, Suzuki K*, Qu J*, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring J, Laurent L, and Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011. 8(6):688-94. (*equal contribution)

34. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011. 14;472: 221-5

Book chapter:

35. Liu GH#, Yang J, Ding Z, Ocampo A, Qu J, Suzuki K, Izpisua Belmonte JC#. Chapter: iPSC disease modeling of laminopathies. Human iPS Cells in Disease Modeling (Springer). 2016. pp 53-67 (#Corresponding author)

Research Interests

Dr. Guang-Hui Liu’s work focuseson using pluripotent stem cell to study and treat aging-associated disorders including neurodegenerative diseases.

Students

已指导学生

丁志超  博士研究生  071010-生物化学与分子生物学  

段顺磊  硕士研究生  085238-生物工程  

李颖  博士研究生  071009-细胞生物学  

潘慧泽  博士研究生  071009-细胞生物学  

王丽霞  博士研究生  0710J6-再生医学  

王平  博士研究生  0710J6-再生医学  

杨济平  博士研究生  071009-细胞生物学  

付丽娜  博士研究生  0710J6-再生医学  

现指导学生

侯薇  硕士研究生  0710J6-再生医学  

颜鹏泽  硕士研究生  0710J6-再生医学  

邓丽萍  博士研究生  0710J6-再生医学  

汪伟  博士研究生  0710J6-再生医学  

程方  硕士研究生  0710J6-再生医学  

张胜  硕士研究生  0710J6-再生医学  

荆耀彬  博士研究生  0710Z1-基因组学  

和溢芳  博士研究生  0710J6-再生医学  

梁楚倩  博士研究生  0710J6-再生医学  

韩旭凌  硕士研究生  071009-细胞生物学  

李洪宇  硕士研究生  071009-细胞生物学  

张慧  硕士研究生  071009-细胞生物学  

季乾昭  硕士研究生  071009-细胞生物学  

邹治然  博士研究生  071009-细胞生物学