General

Guanghui Liu, Ph.D, Prof.

  Principal Investigator

  National Laboratory of Biomacromolecules, IBP  

  1) Using stem cell to study and treat human disease   

  2) Genetic and molecular bases of healthy aging

  3) Targeted genome editing  

  E-mail:ghliu@ibp.ac.cn, Tel:010-64889970

  Fax:010-64871293, Zip code:100101

Research Areas

1) Using stem cell to study and treat human disease

2) Genetic and molecular bases of healthy aging

3) Targeted genome editing

Education

1997-2002, B.S., Peking University Health Science Center

2002-2007, Ph.D., Institute of Biophysics, Chinese Academy of Sciences


  

Experience

2007-2009, Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009-2012, Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2012-, Professor, Institute of Biophysics, Chinese Academy of Sciences

2019-, Professor, Institute of Zoology, Chinese Academy of Sciences

Honors & Distinctions

2018, Tan Jiazhen prize in life sciences innovation
2018-, President, Chinese Society of Aging Cell Research (CSACR)
2018-, Associate Editor, Stem Cell Research & Therapy (Impact factor 4.9)
2017-, Vice president, Chinese Society of Aging Biology (CSAB)
2017, Second class Beijing Science and Technology Award (first place)
2017, Shulan Medical Prize
2017, Youth Scientist of Chinese Academy of Sciences
2017, CSCB Young Investigator
2017, Gerontology Outstanding Contribution Award
2017-, Editorial board, Cell Stress
2017-, Editorial board, Cell Proliferation
2017-, Editorial board, Life Science Alliance
2016-, Vice president, Chinese Society of Regenerative Cell Biology
2016, Innovative Award of “the capital of ten scientific and technological research and management plan”
2016, National Science Foundation for Distinguished Young Scholars
2015, 973 program chief scientist
2015, Bill and Melinda Gates Foundation Grand Challenges 2015-Young Scientist
2015, CSSCR Stem Cell Young Investigator
2015-, Deputy Editor-in-Chief, Protein & Cell (Impact factor 6.2)
2013, Bei Shi-Zhang Young Scientist Award in Biophysics
2012, Thousand Young Talents program of China
2012, National Science Foundation for Excellent Young Scholars
2011, Glenn Aging Foundation fellowship (in US)
2010, California Institute of Regenerative Medicine (CIRM) scholar training grant (in US)
2007, Award by the president of Chinese Academy of Sciences

Publications

  1. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R,     He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J#, Tang     F#, Liu GH#. FOXO3-engineered human ESC-derived vascular     cells promote vascular protection and regeneration. Cell Stem Cell.     2019. 24(3), 447-461 (#Corresponding author)
  2. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W,     Zhang W, Guillen P, Belmonte J, Chan P, Qu J#, Liu GH#.     Stabilizing heterochromatin by DGCR8 alleviates senescence and     osteoarthritis. Nat Commun. 2019. in press (#Corresponding     author)
  3. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S,     Belmonte JC, Chan P, Qu J#, Tang F#, Liu GH#. Upregulation     of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS     Biology. 2019. 17(4):e3000201 (#Corresponding author)
  4. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren     R, Ding J, Chan P, Jiang C, Ye K, Qu J#, Tang F#, Liu GH#.     Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and     osteoarthritis. Cell Reports. 2019. 26(13):3643-3656. (#Corresponding     author)
  5. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu     L, Chu Q, Belmonte JC, Wang Z, Qu J#, Yuan Y#, Liu GH#.     Modeling CADASIL vascular pathologies with patient-derived induced     pluripotent stem cells. Protein Cell. 2019. 10(4):249-271 (#Corresponding     author)
  6. Song M, Belmonte JCI#, Liu GH#. Age-related     cardiopathies gene editing. Aging (Albany NY). 2019.     11(5):1327-1328. (#Corresponding author)
  7. Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang     W, Suzuiki K, Huang YZhang P, Tang     T, Qu J#, Yu Y#, Liu GH#, Qiao J#. Rescue of Premature Aging     Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-mediated Gene     Correction. Protein Cell. 2019. DOI:     10.1007/s13238-019-0623-2 (#Corresponding author)
  8. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z,     Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W#, Liu     GH#, Hu B#. SIRT6 deficiency results in developmental retardation     in cynomolgus monkeys. Nature. 2018. 560(7720):661-665. (#Corresponding     author)
  9. Zhang W, Song M, Qu J#, Liu GH#. Epigenetic     Modifications in Cardiovascular Aging and Diseases. Circ Res.     2018. 123(7):773-786. (#Corresponding author)
  10. Geng L, Liu Z, Zhang W#, Li W, Wu Z, Wang W, Ren R, Su Y, Wang     P, Ju Z, Chan P, Song M#, Qu J#, Liu GH#. Chemical Screen     Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein     Cell. 2018. doi: 10.1007/s13238-018-0567-y. (#Corresponding     author)
  11. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu     X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen     C, Chan P, Li D, Qu J#, Tang F#, Liu GH#.     ATF6 safeguards organelle homeostasis and cellular aging in human     mesenchymal stem cells. Cell Discovery. 2018. Jan     5;4:2. (#Corresponding author)
  12. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y,     Sang Y, Chan P, Chen C, Qu J#, Suzuki K#, Belmonte JC#, Liu GH#.     Differential stem cell aging kinetics in HutchinsonGilford progeria syndrome and Werner syndrome. Protein Cell.     2018. 9(4):333-350. (#Corresponding author)
  13. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu     GH#, Wang L#. Metformin alleviates human cellular aging by     upregulating the ER peroxidase GPx7. Aging Cell.     2018.17(4):e12765. (#Corresponding author)
  14. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L,     Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li     J, Qiao J, Xu T#, Qu J#, Liu GH#.     Visualization of aging-associated chromatin alterations with an engineered     TALE system. Cell Res. 2017. 27(4):483-504 (#Corresponding     author)
  15. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W,     Chan P, Belmonte JC, Qu J#, Tang F#, Liu GH#. Genetic     enhancement in cultured human adult stem cells conferred by a single     nucleotide recoding. Cell Res. 2017. 27(9):1178-1181 (#Corresponding     author)
  16. Ren R, Ocampo A, Liu GH#, Belmonte JC#.     Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell     Metab. 2017. 26(3):460-474. (#Corresponding author)
  17. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu     X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y#, Qu J#, Liu GH#.     CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral     sclerosis patient iPSCs. Protein Cell. 2017. 8(5):365-378 (#Corresponding     author)
  18. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH#,     Misteli T#, Repression of the antioxidant NRF2 pathway in premature aging.     Cell. 2016. 165(6):1361-74 (#Corresponding author)
  19. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren     R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li     J, Qu J#, Tang F#, Liu GH#. SIRT6 safeguards human     mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell     Res. 2016. 26(2):190-205.(#Corresponding author)
  20. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim     EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M,     Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X,     Jafari M, Esteban CR, Berggren WT, Lajara J, Nuez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu     GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In     vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted     integration. Nature. 2016. 540(7631):144-149.
  21. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y,     Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls     Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt     Signaling. Cell Stem Cell. 2016. 7;18(4):495-507
  22. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y,     Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC#, Qu J#, Liu     GH#. Modeling Xeroderma Pigmentosum associated neurological     pathologies with patients-derived iPSCs. Protein Cell. 2016.7(3):210-21.(#Corresponding     author)
  23. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z,     Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J#, Zhang W#, Liu GH#.     Vitamin C alleviates aging defects in a stem cell model for Werner     syndrome. Protein Cell. 2016. 7(7):478-88. (#Corresponding     author)
  24. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu     X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z,     Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl     A, Soligalla RD, Reddy P, Esteban CR, Tang F#, Liu GH#,     Belmonte JC#. A Werner syndrome stem cell model unveils     heterochromatin alterations as a driver of human aging. Science. 2015;     348(6239):1160-3.(#Corresponding author)
  25. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL,     Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N,     Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S,     Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM,     Moraes CT, Izpisua Belmonte JC. Selective Elimination of Mitochondrial     Mutations in the Germline by Genome Editing. Cell. 2015;     161(3):459-469
  26. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L,     Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C,     Belmonte JC, Chen Z, Wang X, Jiang T, Qu J#, Tang F#, Liu GH#.     PTEN deficiency reprograms human neural stem cells towards a glioblastoma     stem cell-like phenotype. Nat Commun.2015. 6:10068.(#Corresponding     author)
  27. Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren     R, Aizawa E, Zhang F, Xu X, Soligalla R, Chen F, Kim J, Kim NY, Liao HK,     Benner C, Esteban CR, Jin Y, Liu GH#, Li Y#, Belmonte     JC#. Targeted gene correction in human disease-specific induced     pluripotent stem cells minimally impacts whole-genome mutational load. Cell     Stem Cell. 2014; 15, 3136.  (#Corresponding     author)
  28. Liu GH#,     Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang     W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y,     Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R,     Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Esteban C, Izpisua     Belmonte JC#. Modeling Fanconi Anemia pathogenesis and therapeutics     using integration-free patient iPSCs. Nat Commun. 2014.     7;5:4330.  (#Corresponding author)
  29. Yang J, Cai N, Yi F, Liu GH#, Qu J#,     Belmonte JC#. Gating pluripotency via nuclear pores. Trends     Mol Med. 2014. 20(1):1-7. (#Corresponding author)
  30. Wu K, Ren R, Su W, Wen Bo, Zhang Yuying, Yi Fei, Qiao X, Yuan     T, Wang J, Liu L, Belmonte JC#, Liu GH#, Chen C#.     A novel suppressive effect of alcohol dehydrogenase 5 in neuronal     differentiation. J Biol Chem. 2014. 289(29):20193-9. (#Corresponding     author)
  31. Xu XL#, Yang JP, Fu LN, Ren RT, Yi F, Suzuki K, Liu K,     Ding ZC, Qu J, Zhang WQ, Li Y, Yuan TT, Yuan GH, Sui LN, Guan D, Duan SL,     Pan HZ, Wang P, Zhu XP, Montserrat N, Li M, Bai RJ, Liu L, Izpisua     Belmonte JC, Liu GH#. Direct reprogramming of porcine     fibroblasts to neural progenitor cells. Protein Cell. 2014.     5(1):4-7. (#Corresponding author)
  32. Xu X, Duan S, Yi F, Ocampo A, Liu GH#, Belmonte     JC#. Mitochondrial regulation in pluripotent stemcells. Cell     Metab. 2013. 18:325-32. (#Corresponding author)
  33. Pan H, Cai N, Li M, Liu GH#, Belmonte JC#.     Autophagic control of cell stemness. EMBO Mol. Med. 2013     5(3):327-31. (#Corresponding author)
  34. Zhang WQ, Qu J, Suzuki K, Liu GH#, Belmonte JC#.     Concealing cellular defects in pluripotent stem cells. Trends Cell     Biol. 2013. 23(12):587-92. (#Corresponding author)
  35. Guan D, Zhang W, Zhang W#, Liu GH#,     Belmonte JC#. Switching cell fate, ncRNAs coming to play. Cell     Death Dis. 2013.17;4:e464. (#Corresponding author)
  36. Sui L, Liu GH#, Belmonte JC#. hESC-derived     pancreatic progenitors. Cell Res. 2013. 23(5):592-4. (#Corresponding     author)
  37. Zhang K, Yi F, Liu GH#, Belmonte JC#. New     march towards the regeneration of sensation and cognition: hear more, see     more and learn more. J Mol Cell Biol. 2013; 5(2):151-3. (#Corresponding     author)
  38. Liu W, Li M, Qu J, Yi F#, Liu GH#. Reevaluation     of the safety of induced pluripotent stem cells: a call from somatic     mosaicism. Protein Cell. 2013; 4(2):83-5. (#Corresponding     author)
  39. Liu GH#, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz     S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R,     Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte     JC#. Progressive degeneration of human neural stem cells caused by     pathogenic LRRK2. Nature. 2012; 491(7425):603-7. (#Corresponding     author) 
  40. Li M*, Liu GH*, Belmonte JC. Navigating the     epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell     Biol. 2012; 13(8):524-35. (*equal contribution)
  41. Liu GH#,     Ding Z, Izpisua Belmonte JC#. iPSC technology to study human aging     and aging-related disorders. Curr Opin Cell Biol. 2012;     24(6):765-74.(#Corresponding author)
  42. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo     A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu     GH, Gage FH, Izpisua Belmonte JC. Cord blood-derived neuronal     cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U     S A. 2012; 109(31):12556-61
  43. Liu GH#, Li M, Qu J, Belmonte JC#. Gating neural development and     aging via nuclear pores. Cell Res. 2012; 22(8):1212-4. (#Corresponding     author)
  44. Wang P, Zhang W, Yang J, Qu J#, Liu GH#.     Higher-order genomic organization in pluripotent stem cells. Protein     Cell. 2012; 3(7):483-6. (#Corresponding author)
  45. Liu GH*,     Suzuki K*, Qu J*, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J,     Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K,     LoringJ,Laurent L, and Belmonte JC. Targeted gene correction of     laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell     Stem Cell. 2011; 8(6):688-94. (*equal contribution)
  46. Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J,     Sancho-Martinez I, Liu GH, Belmonte JC. Efficient correction     of hemoglobinopathy-causing mutations by homologous recombination in     integration-free patient iPSCs. Cell Res. 2011;     21(12):1740-4
  47. Pan H, Zhang W, Zhang W#, Liu GH#. Find     and Replace: editing human genome in pluripotent stem cells. Protein     Cell. 2011; 2(12):950-6.  (#Corresponding author)
  48. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC#. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature.2011; 14;472: 221-5

Book chapter:

Liu GH#,Yang J, Ding Z, Ocampo A, Qu J, Suzuki K, Izpisua Belmonte JC#. Chapter: iPSC disease modeling of laminopathies.Human iPS Cells in Disease Modeling (Springer). 2016. pp 53-67 (#Corresponding author)

Research Interests

Dr. Guang-Hui Liu’s work focuseson using pluripotent stem cell to study and treat aging-associated disorders including neurodegenerative diseases.

Students

已指导学生

丁志超  博士研究生  071010-生物化学与分子生物学  

段顺磊  硕士研究生  085238-生物工程  

李颖  博士研究生  071009-细胞生物学  

潘慧泽  博士研究生  071009-细胞生物学  

王丽霞  博士研究生  0710J6-再生医学  

王平  博士研究生  0710J6-再生医学  

杨济平  博士研究生  071009-细胞生物学  

付丽娜  博士研究生  0710J6-再生医学  

现指导学生

侯薇  硕士研究生  0710J6-再生医学  

颜鹏泽  硕士研究生  0710J6-再生医学  

邓丽萍  博士研究生  0710J6-再生医学  

汪伟  博士研究生  0710J6-再生医学  

程方  硕士研究生  0710J6-再生医学  

张胜  硕士研究生  0710J6-再生医学  

荆耀彬  博士研究生  0710Z1-基因组学  

和溢芳  博士研究生  0710J6-再生医学  

梁楚倩  博士研究生  0710J6-再生医学  

韩旭凌  硕士研究生  071009-细胞生物学  

李洪宇  硕士研究生  071009-细胞生物学  

张慧  硕士研究生  071009-细胞生物学  

季乾昭  硕士研究生  071009-细胞生物学  

邹治然  博士研究生  071009-细胞生物学