基本信息
刘光慧  男  博导  中国科学院生物物理研究所
电子邮件: ghliu@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

1. 基于人多能干细胞(PSCs;包括iPSC和ESCs)的人类疾病模型和精准治疗体系
    利用患者诱导性多能干细胞(iPSC)和体外创建的“疾病”胚胎干细胞(ESC),结合定向分化和细胞移植技术,在功能基因组水平研究人类疾病的分子机理及新型靶标;发展基于干细胞技术的药物筛选和评价体系;探索结合自体干细胞和基因靶向编辑进行个体化治疗的可行性。

2. 人类健康衰老(healthy aging)的分子遗传学基础
    结合干细胞和基因组靶向修饰技术,研究人类衰老(如脑衰老)和老年病(如神经退行性疾病)的细胞分子机理和(表观)遗传学基础,探索延缓衰老和防治老年病的方法和手段,以期实现“健康长寿”的梦想。

招生信息

招生专业:  
细胞生物学


招生方向: 
1. 基于多能干细胞的人类疾病模型和精准治疗体系
2. 人类健康衰老(healthy aging)的分子遗传学基础


工作经历


教育背景:
2002-09--2007.07 中科院生物物理所 博士
1997-08--2002.07 北京大学 学士


工作经历:
2011.08--今 中科院生物物理所 研究员
2009.09--2011.08 美国Salk生物学研究所 research associate
2007.08--2009.08 美国Scripps研究所 research associate

工作简历
2014-09~现在, 中国科学院大学, 岗位教授
2011-08~现在, 中国科学院生物物理研究所, 研究员
2009-09~2012-09,美国Salk生物学研究所, research associate
2007-09~2009-08,美国Scripps研究所, research associate

专利与奖励

代表性发明专利:

1)  一种将人类成纤维细胞转分化为视网膜色素上皮细胞的方法。
         
专利号: ZL201310222217.2
2)  一组人类肌细胞的新型分子标记物及其应用。

         
专利号: ZL201310370253.3

3  一种利用重编程制备猪神经干细胞的方法。
         
专利号: ZL201410027420.9


 

奖励信息:

2015,大挑战2015青年科学家奖(科技部和比尔盖茨基金会联合授予)

2015,干细胞青年研究员奖

2013,贝时璋青年生物物理学家奖

2012,国家青年千人计划

2012,国家自然科学基金委优秀青年基金

2012,北京大学医学部优秀校友

2011,美国Glenn衰老研究基金会基金

2010,美国加州再生医学研究所 (CIRM)基金

2007,中科院院长奖

2006,中科院-BHP Billiton

出版信息

代表性论文:

1.Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, III JY, Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeriasyndrome.  Nature. 2011; 14;472: 221-5


2. Liu GH*, Suzuki K*, Qu J*, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, LoringJ,Laurent L, and Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011; 8(6):688-94. (*equal contribution)


3. Li M*, Liu GH*, Belmonte JC. Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol.2012; 13:524-35.  (*equal contribution)


4.Liu GH#, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Ren B, Wagner U, Kim A, Li Y, Goebl A, Kim J, Soligalla R, Dubova I, Thompson J, Yates J III, Esteban C, Sancho-Martinez I, Belmonte JC#. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012; 491:603-7. (#Corresponding author) 


5. Liu GH#, Ding Z, Izpisua Belmonte JC#. iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol. 2012; 24:765-74. (#Corresponding author) 


6. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012; 109(31):12556-61


7. Xu X, Duan S, Yi F, Ocampo A, Liu GH#, Belmonte JC#. Mitochondrial regulation in pluripotent stemcells. Cell Metab. 2013. Sep 3;18(3):325-32. (#Corresponding author)


8. Zhang WQ, Qu J, Suzuki K, Liu GH#, Belmonte JC#.Concealing cellular defects in pluripotent stem cells. Trends Cell Biol. 2013. 23(12):587-92. (#Corresponding author) 


9. Pan H, Cai N, Li M, Liu GH#, Izpisua Belmonte JC#. Autophagic control of cell stemness. EMBO Mol. Med. 2013. 5:327-31. (#Corresponding author) 


10. Guan D, Zhang W, Zhang W, Liu GH#, Belmonte JC#. Switching cell fate, ncRNAs coming to play. Cell Death Dis. 2013. 4:e464. (#Corresponding author)


11. Yang J, Cai N, Yi F, Liu GH#, Qu J#, Belmonte JC#. Gating pluripotency via nuclear pores. Trends Mol Med. 2014. Jan; 20(1):1-7. (#Corresponding author)


12. Wu K, Ren R, Su W, Wen Bo, Zhang Yuying, Yi Fei, Qiao X, Yuan T, Wang J, Liu L, Belmonte JC#, Liu GH#, Chen C#. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation. J Biol Chem. 2014. 289(29):20193-9. (#Corresponding author)


13. Liu GH#, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla R, Goebl A, Aizawa E, Kim N, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo J, Surralles J, Esteban C, Izpisua Belmonte JC#. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient iPSCs. Nat Commun. 2014. 7;5:4330. (#Corresponding author)


14.Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla R, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH#, Li Y#, Belmonte JC#. Targeted gene correction in human disease-specific induced pluripotent stem cells minimally impacts whole-genome mutational load. Cell Stem Cell. 2014; 15, 31–36.  (#Corresponding author)


15. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC.Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell. 2015; 161:459-469

                                 

16. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F#, Liu GH#, Belmonte JC#. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science.2015; 348(6239):1160-3.(#Corresponding author)


17. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J#, Tang F#, Liu GH#. PTEN deficiency reprograms human neuralstem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015. 6:10068. (#Corresponding author)

 

18. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J#, Tang F#, Liu GH#. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016. 26(2):190-205. (#Corresponding author)


19. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507.

 

著作章节 (Book chapter)

Liu GH#, Yang J, Ding Z, Ocampo A, Qu J, Suzuki K, Izpisua Belmonte JC#. Chapter: iPSC disease modeling of laminopathies. Human iPS Cells in Disease Modeling (Springer), 2016, pp 53-67 (#Corresponding author)

科研活动

科研项目:

  1. 2015-2019国家重大科学研究计划(973首席科学家

    项目名称:干细胞衰老的细胞分子机理及转化应用研究

  2. 2014-2018 国家自然科学基金重点项目,课题负责人

    项目名称: 人类成年早衰症模型的建立及其分子机制研究

  3. 2013-2015国家自然科学基金委优青项目,课题负责人

    项目名称: 结合多能干细胞和基因组编辑技术研究人类衰老及其相关疾病的细胞分子机理

  4. 2013-2016 国家自然科学基金委面上项目,课题负责人

    项目名称: 基于诱导性多能干细胞和基因组编辑技术的帕金森病治疗体系

  5. 2012-2015中国科学院干细胞与再生医学战略性先导科技专项,子课题负责人

    项目名称:人成体细胞向神经干细胞的转分化及其靶向基因修饰研究

  6. 2015-2017 北京市科学技术委员会重点培育项目,课题负责人

    项目名称:遗传靶向修饰在改善人干细胞移植效果和安全性方面的可行性研究和机制探索

  7. 2014-2016 北京市自然科学基金重点项目,课题负责人

    项目名称:基于成体干细胞致癌突变靶向导入的新型人类恶性肿瘤模型



指导学生:

博士毕业2人,博士生在读4人,硕士生在读3人

参与会议
(1)Using stem cell and gene editing techniques to study and treat aging-associated disorders   2018-04-22
(2)Absence of SIRT6 results in developmental retardation in cynomolgus monkeys   2018-02-24
(3)Using stem cell and gene editing techniques to study and treat aging-associated disorders   2018-02-16
(4)Using stem cell and gene editing techniques to study and treat aging-associated disorders   冷泉港亚洲会议   2017-11-11
(5)Using stem cell and gene editing techniques to study and treat aging-associated disorders   冷泉港亚洲会议   2017-11-06
(6)未来领军人才计划   STS论坛-未来领军人才计划   2017-09-29
(7)Using stem cell and gene editing techniques to study and treat aging-associated disorders    2017年度基因组学,干细胞,组织再生学术研讨会   2017-08-28
(8)Using stem cell and gene editing techniques to study and treat aging-associated disorders.   全球华人科学家大会   2017-06-29
(9)Using stem cell and gene editing techniques to study and treat aging-associated disorders   2017-05-17
(10)Using stem cell and gene editing techniques to study and treat aging-associated disorders.   第12届海峡两岸细胞生物学研讨会   2017-03-13
(11)Using stem cell and gene editing techniques to study and treat aging-associated disorders.   2017-03-02
(12)Using stem cell and gene editing techniques to study and treat aging-associated disorders.   2016-11-01
(13)Using stem cell and gene editing techniques to study and treat aging-associated disorders   2016-10-17
(14)Using stem cell and gene editing techniques to study and treat aging-associated disorders,    中美联合峰会论坛(美国科学院)   2016-10-13
(15)Using stem cell and gene editing techniques to study and treat aging-associated disorders,    2016-08-21
(16)Using pluripotent stem cell to study and treat aging-associated diseases.   2016-06-22
(17)Using pluripotent stem cell to study and treat aging-associated diseases   BIOMEDICAL INNOVATION FOR HEALTHY LONGEVITY   刘光慧   2016-04-25
(18)Using stem cell and gene editing techniques to study and treat human genetic disorders   6th Congress of the Asia Pacific Initiative on Reproduction    刘光慧   2016-04-08
(19)Using pluripotent stem cell to study and treat aging-associated diseases   冷泉港亚洲会议   刘光慧   2015-09-14
(20)Using pluripotent stem cell to study and treat aging-associated diseases   Gordon研究会议   刘光慧   2015-06-07
(21)Using pluripotent stem cell to study and treat aging-associated diseases   冷泉港亚洲会议   刘光慧   2014-08-24
(22)Using iPSC to study diseases and develop therapies   中国细胞生物学学会第十二次全体会员代表大会暨学术大会   Guanghui Liu   2011-08-07
(23)Correction of laminopathies-associated LMNA mutations in patients-derived iPSCs by specific gene targeting   美国冷泉港会议   Guanghui Liu   2011-08-01
(24)Using iPSC technology to study ageing and dedifferentiation of ageing cells   美国冷泉港会议   Guanghui Liu   2010-08-01
(25)Regulation of myogenesis by the nuclear envelope protein NET39   美国冷泉港会议   Guanghui Liu   2008-08-01