General

Changsheng Zhang, Prof. Dr.

Key Laboratory of Tropical Marine Bio-resources and Ecology, 
Guangdong Key Laboratory of Marine Materia Medica,
RNAM Center for Marine Microbiology, 
South China Sea Institute of Oceanology, Chinese Academy of Sciences,

Email: czhang@scsio.ac.cn, czhang2006@gmail.com
ORCID: https://orcid.org/0000-0003-2349-3138

TEL. & FAX: (86)-20-8902 3038
Address: 164 West Xingang Road, Guangzhou, 510301 China        

Research Areas

Prof. Zhang’s researches focus on the discovery, biosynthesis, metabolic engineering and synthetic biology of marine microbial natural products, and their development as medicines for human health, industrial and agricultural applications.  He has published more than 170 original papers, including Science, Nat Biotechnol, Nat Chem Biol, Nat Commun, Mol Cell, J Am Chem Soc, Angew Chem Int Ed, Chem Sci, Org Lett,  etc. He has received numerous awards for his research.


1.  Discovery of novel bioactive natural products

    1) Developing new methods to facilitate the discovery of novel bioactive natural products from marine microorganisms upon big data mining

    2) Evaluating their bioactivity for drug-lead development


2.  Biosynthesis and enzyme biocatalysis

    1) Elucidating the biosynthetic pathway of novel drug-like molecules

    2) Unveiling the unique catalytic mechanisms and structural features of biosynthetic enzymes

    3) Enzyme engineering for industrial and agricultural applications


3.  Metabolic engineering and synthetic biology

    1) Structure-activity optimization and yield improvement of drug-like molecules via metabolic engineering

    2) Rational design of artificial pathways and cell factories via synthetic biology for biomanufacturing


Selected Key Publications

Fang et al Journal of the American Chemical Society, 2024, 146 (24): 16478–16489. DOI: 10.1021/jacs.4c02841.

Li et al  Angewandte Chemie International Edition, 2024, 63 (22): e202403365. DOI: 10.1002/anie.202403365.

Liu et al Journal of the American Chemical Society, 2023, 145 (50): 27886–27899. DOI: 10.1021/jacs.3c11772. 

Jiang et al Angewandte Chemie International Edition, 2023, 62 (51): e202310728. DOI: 10.1002/anie.202310728.

Tan et al Angewandte Chemie International Edition, 2023, 62 (27): e202302043. DOI: 10.1002/anie.202302043.

Yang et al Nature Communications, 2022, 13: 5386. DOI: 10.1038/s41467-022-33131-0. 

De et al Nature Communications, 2022, 13: 4896. DOI: 10.1038/s41467-022-32641-1.

Zhang et al Science China Chemistry, 2021, 64 (10): 1736–1742. DOI: 10.1007/s11426-021-1072-6.

Zhu et al Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069. DOI: 10.1002/anie.202004978.

Huang et al Nature Communications, 2018, 9 (1): 2088. DOI: 10.1038/s41467-018-04487-z.

Zhang et al Science, 2006, 313(5791): 1291-1294. DOI: 10.1126/science.1130028. 

Education and Experience

Education


1994, B.E.    Shanghai Jiao Tong University, China

1997, M.S.   East China University of Science & Technology, China

                    under the supervision of Prof. Huizhan Zhang, 
                      

2002, Ph.D.  Bergische Universität Wuppertal, Germany

                    ​under the supervision of Prof. Dr. Wolfgang Piepersberg,                       

Working Experience


1997-1998, Research assistant, Shanghai Pacific Hi-Biotech Co. Ltd. 

2003-2008, Postdoctoral research associate and assistant scientist under the guidance of Prof. Dr. Jon Thorson, School of Pharmacy, University of Wisconsin-Madison, USA 

2008-present, Professor of marine microbial natural products in the South China Sea Institute of Oceanology, China

Recruiting Students

Majors
070703-Marine Biology
070321-Chemical Biology
071005-Microbiology


Welcome students (including international students) interested in these areas to join in our group!

Honors & Distinctions

2024: Editor, Marine Life Science & Technology

2023："Top 10 Scientific and Technological Advances in Oceanology and Limnology in China" in 2022

2022: Associate Editor, Microbiome

2022: Associate Editor, Environmental Microbiome

2021: "Outstanding Teacher Award in SCSIO (2021)", SCSIO

2021: Fellow of Royal Society of Chemistry (FRSC)

2020: Editorial board, Molecules (Natural Products Chemistry Section)

2020: "Outstanding Teacher Award in SCSIO (2020)", SCSIO

2019: Editorial board member, Natural Product Reports

2018: "Outstanding Teacher Award in 2018", Chinese Academy of Sciences

2018: "Outstanding Teacher Award in SCSIO (2018)", SCSIO

2017: Winner of "Special Government Allowance"

2016: "National Leading Innovative Scientist in S&T"

2016: "Youth Prize of the Fourth Zeng Cheng Kui Award in Marine Science and Technology", Chinese Society for Oceanology and Limnology, CSOL

2015: "Outstanding Scholar" of "Guangdong Specialist Supporting Plan"

2014: "Young Scientists with Special contributions"

2014: "Mid-Aged Leading Innovative Scientist in S&T"

2013: "Excellence" in the final evaluation of BR, Chinese Academy of Sciences

2012:  "Outstanding S&T Worker of China", China Association for Science and Technology

2011: "National Natural Science Fund for Distinguished Young Scholars of China", National Natural Science Foundation of China

2005: "Anatrace Best Poster Award" , the First Midwest Carbohydrate Symposium, Toledo, Ohio, USA 

Publications

# (co-first author), * (corresponding author)

2024


184. Zoltán Czenke, Attila Mándi, Sándor Balázs Király, Attila Kiss-Szikszai, Anita Kónya-Ábrahám,  Anna Szabados, Krisztián Cserepes, Attila Bényei, Changsheng Zhang, Máté Kicsák,* and Tibor Kurtán.* VCD Analysis of Axial Chirality in Synthetic Stereoisomeric Biaryl-Type bis-Isochroman Heterodimers with Isolated Blocks of Central and Axial Chirality. International Journal of Molecular Sciences, 2024, 25, accept. DOI: 10.3390/ijms25179657. Published: 6 September 2024.

183. Liping Zhang, Peng Jiang, Hongbo Jin, Changsheng Zhang.* Achieving Regioselectivity for Remote C–H Activation by Substructure Conformations: an Approach of Paralogous Cytochrome P450 Enzymes. Chemistry - A European Journal, 2024, DOI: 10.1002/chem.202402635 (invited review). Accepted manuscript online: 28 August 2024;

182. Mengran Zhao,# Wenjun Zhang,# Chunfang Yang,* Liping Zhang, Huarong Huang, Yiguang Zhu, Disna Ratnasekera, and Changsheng Zhang.* Discovery of Kebanmycins with Antibacterial and Cytotoxic Activities from the Mangrove-Derived Streptomyces sp. SCSIO 40068. Journal of Natural Products, 2024,  87 (6): 1591–1600. DOI: 10.1021/acs.jnatprod.4c00232. Published online 11 June 2024; Published in issue 28 June 2024.

181. Chunyan Fang,# Liping Zhang,# Yongchao Wang,# Weiliang Xiong, Zier Yan, Wenjun Zhang, Qingbo Zhang, Bijun Wang,* Yiguang Zhu,* and Changsheng Zhang.* Discovery and biosynthesis of cihanmycins reveal cytochrome P450-catalyzed intramolecular phenol coupling reactions. Journal of the American Chemical Society, 2024, 146 (24): 16478–16489. DOI: 10.1021/jacs.4c02841. Published online 6 June 2024; Published in issue 19 June 2024.

180. Liangliang Bai,# Linping Wu,# Changsheng Zhang, Zhiwen Liu, Liang Ma, Jing Ni, Dezhen He, Mingxuan Zhu, Shaoyong Peng, Xiaoxia Liu, Huichuan Yu, Yuhe Lei, Yanxin Luo, Yu Zhang, Xiaolin Wang,* Gang Wei,* Yingjie Li.*  Replenishment of mitochondrial Na+ and H+ by ionophores potentiates cutaneous wound healing in diabetes. Materials Today Bio, 2024, DOI: 10.1016/j.mtbio.2024.101056. Available online 16 April 2024;

179. Yanqin Li,# Mengjing Cong,# Xiufeng Zhang, Yiguang Zhu, Wenjun Zhang, Yonghong Liu, Changsheng Zhang,* Junfeng Wang,* and Yan Yan.* An Enzymatic Carbon-Carbon Bond Cleavage and Aldol Reaction Cascade Converts an Angular Scaffold into the Linear Tetracyclic Core of Ochraceopones. Angewandte Chemie International Edition, 2024, 63 (22): e202403365. DOI: 10.1002/anie.202403365; Angewandte Chemie, 2024, 136 (22): e202403365. DOI: 10.1002/ange.202403365. Accepted manuscript online: 07 March 2024; Version of Record online: 26 March 2024; Issue Online: 17 May 2024.

178. YAO Jinglong, CHEN Haitao, ZHANG Changsheng,* YANG Min, WANG Weiqiang, WEI Yuansong, PAN Gang, WANG Yawei, LUO Yao, ZHONG Hui, ZHANG Zhenqiu. Promote high-quality development of China-Sri Lanka Joint Center for Education and Research by practicing new development philosophy. Bulletin of Chinese Academy of Sciences, 2024, 39(2): 381-386. DOI: 10.16418/j.issn.1000-3045.20230908002. (in Chinese). Publised 21 Feb 2024.

177. Youzhe Chen,# Hongbo Jin,# Weiliang Xiong, Zhuangjie Fang, Weiguang Sun,Yiguang Zhu, Liping Zhang, Yonghui Zhang, Wenjun Zhang,* Changsheng Zhang.* Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams. Organic Letters, 2024, 26 (8): 1677–1682. DOI: 10.1021/acs.orglett.4c00168. Published online 16 February 2024; Published in issue 1 March 2024.

176. Wei Liu,# Shilan Zhai,# Liang Ma,* Liping Zhang, Yuchan Chen, Zhiyong Liu, Tianyu Zhang, Weimin Zhang, Changsheng Zhang,* Wenjun Zhang.* Expanding the Chemical Diversity of Grisechelins via Heterologous Expression. Journal of Natural Products, 2024, 87 (2): 371-380. DOI: 10.1021/acs.jnatprod.3c01132. Published online 1 February 2024; Published in issue 23 February 2024.

175. Bidhan Chandra De, Chunfang Yang, Chunshuai Huang, Changsheng Zhang, and Wenjun Zhang.* Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism. Organic & Biomolecular Chemistry, 2024, 22 (6): 1152-1156. DOI: 10.1039/d3ob01920a. first published on 03 Jan 2024; advance article 12 Jan 2024; in issue 7 Feb 2024.

Graphical abstract: Non-enzymatic synthesis of C-methylated fluostatins: discovery and reaction mechanism

174. Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Naturally Occurring and Widespread Resistance to Bioactive Natural Products. ChemMedChem, 2024, 19 (3): e202300619. DOI: 10.1002/cmdc.202300619 (invited review). Accepted manuscript online: 16 December 2023; Version of Record online: 12 January 2024; Issue Online: 01 February 2024.  


2023

173. Kai Liu,# Jinyan Zhang,# Guangtao Zhang,#* Liping Zhang, Zhen Meng, Liang Ma, Wenjun Zhang, Weiliang Xiong, Yiguang Zhu, Binju Wang,* Changsheng Zhang.* Deciphering Deoxynybomycin Biosynthesis Reveals Fe(II)/α-Ketoglutarate-Dependent Dioxygenase-Catalyzed Oxazoline Ring Formation and Decomposition. Journal of the American Chemical Society, 2023, 145 (50): 27886–27899. DOI: 10.1021/jacs.3c11772. Publication online 6 December, 2023; Published in issue 20 December 2023. ("Hot off the press" in Natural Product Reports, 2024, 41 (2): 157–161. DOI: 10.1039/d4np90005g).

172. Peng Jiang,# Hongbo Jin,# Guangtao Zhang, Wenjun Zhang, Wei Liu, Yiguang Zhu, Changsheng Zhang,* Liping Zhang.* A Mechanistic Understanding of the Distinct Regio- and Chemo-selectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angewandte Chemie International Edition, 2023, 62 (51): e202310728. DOI: 10.1002/anie.202310728; Angewandte Chemie, 2023, 135 (51):  e202310728. DOI: 10.1002/ange.202310728. Accepted manuscript online: 02 November 2023; Version of Record online: 14 November 2023; Issue Online: 11 December 2023.

171. Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351. DOI: 10.1021/acs.orglett.3c02231. Published online 22 August 2023; Published in issue 1 September 2023. ("Hot off the press" in Natural Product Reports, 2023, 40 (10): 1590-1594. DOI: 10.1039/D3NP90045B).

170. Xiaoyang Zhao#, Youzhe Chen#, Ting Long, Zhiying Liu, Qingbo Zhang, Haibo Zhang, Yan Yan, Changsheng Zhang,* Yiguang Zhu*. Genome Mining and Biosynthetic Reconstitution of Fungal Depsidones Reveal a Dual Functional Cytochrome P450 for Ether Formation. Journal of Natural Products, 2023,  86 (8): 2046–2053. DOI: 10.1021/acs.jnatprod.3c00609. Published online 11 August 2023; Published in issue 25 August 2023.

169. Ke-Gang Linghu, Tian Zhang, Guang-Tao Zhang, Peng Lv, Wen-Jun Zhang, Guan-Ding Zhao, Shi-Hang Xiong, Qiu-Shuo Ma, Ming-Ming Zhao, Meiwan Chen, Yuan-Jia Hu, Changsheng Zhang,* Hua Yu.* Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy. Journal of Pharmaceutical Analysis, 2024, 14 (3): 401-415. DOI: 10.1016/j.jpha.2023.07.009. Pre-proof Available online 17 July 2023; corrected proof online 7 Feb 2024; Version of Record 1 April 2024.

168. Mengyi Zhu,# Lijuan Wang,# Haibo Zhang, Liping Zhang, Bin Tan, Qi Huang, Yiguang Zhu, and Changsheng Zhang.* Biosynthesis and engineered overproduction of everninomicins with promising activity against multidrug-resistant bacteria. ACS Synthetic Biology, 2023, 12 (5): 1520–1532. DOI: 10.1021/acssynbio.3c00055. Published online 21 April 2023; Published in issue 19 May 2023.

167. Bin Tan#, Liping Zhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu,* Changsheng Zhang.* A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27): e202302043. DOI: 10.1002/anie.202302043; Angewandte Chemie, 2023, 135 (27): e202302043. DOI: 10.1002/ange.202302043. First published online 19 April 2023; Version of Record online: 09 May 2023; Issue Online: 27 June 2023; "Hot paper" in Angew Chem. (Featured in CAS, CAS Weibo, GDKJB, X-MOL,  SCSIO)

166. Lijuan Wang#, Mengyi Zhu#, Qingbo Zhang, Shilan Zhai, Yiguang Zhu, Haibo Zhang,* and Changsheng Zhang.* Biosynthetic diversification of fidaxomicin aglycones by heterologous expression and promoter refactoring. Journal of Natural Products, 2023, 86 (4): 986–993. DOI: 10.1021/acs.jnatprod.3c00001. Published online 12 April 2023; Published in issue April 28 2023.

165. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang*, Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979–985. DOI: 10.1021/acs.jnatprod.2c01169. Published online 15 March 2023; Published in issue April 28 2023.

164. Ziqian Cheng,# Qingbo Zhang,# Jing Peng,# Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven discovery of benzoxazole alkaloids from the marine-derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821. DOI:  10.3390/molecules28020821. Published 13 January 2023.

163. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, 41 (12): 1478–1484. DOI: 10.1002/cjoc.202200818. First Published 17 January 2023; Version of Record online: 30 March 2023; Issue Online: 15 May 2023. (Preprint January 06 2023, DOI: 10.22541/au.167303804.43320409/v)

162. Bin Tan, Qingbo Zhang*, Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84. DOI: 10.1021/acs.jnatprod.2c00772. Published online 6 January 2023; Published in issue 27 January 2023.

161. Xuemin Ding, Weixia Ye, Bin Tan, Qiaoyun Song, Yuchan Chen, Wei Liu, Lili Sun, Wei Tang, Yulei Qiao, Qingbo Zhang, Haibo Zhang, Ying Wang, Weimin Zhang, Changsheng Zhang*, Wenjun Zhang*. Talachalasins A-C, undescribed cytochalasans with a 16β-methyl or 2-oxabicyclo­[3.3.1]nonan-3-one unit from the deep-sea-derived fungus Talaromyces muroii sp. SCSIO 40439. Chinese Journal of Chemistry, 2023, 41 (8): 915–923. DOI: 10.1002/cjoc.202200744. First published: 05 January 2023; Version of Record online: 23 February 2023; Issue Online: 15 March 2023.


2022


160. Chunyan Fang, Qingbo Zhang, Wenjun Zhang,  Changsheng Zhang*, and Yiguang Zhu*. Discovery of efrotomycin congeners and heterologous expression-based insights into the self-resistance mechanism. Journal of Natural Products, 2022, 85 (12): 2865–2872. DOI: 10.1021/acs.jnatprod.2c00986. Epub 29 November 2022.

159. Bin Tan, Qingbo Zhang*, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103. DOI: 10.1016/j.tet.2022.133103. Epub 29 October 2022.

158.  Tingting Xu,# Qingqing Gan,# Qiang Liu, Ruidong Chen, Xuhui Zhen, Changsheng Zhang and Jinsong Liu*. Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel activator-dependent form of GT family. Acta Crystallographica Section D Structural Biology, 2022, 78 (10): 1235-1248. DOI: 10.1107/S2059798322008658. Epub 27 September 2022.

157. Chunfang Yang,# Liping Zhang,# Wenjun Zhang, Chunshuai Huang, Yiguang Zhu, Xiaodong Jiang, Wei Liu, Mengran Zhao, Bidhan Chandra De, Changsheng Zhang*. Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation. Nature Communications, 2022, 13, 5386. DOI: 10.1038/s41467-022-33131-0. Epub 2022 Sept 14.

156. Bidhan Chandra De#, Wenjun Zhang#, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-wen Liu*, Changsheng Zhang*. Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature Communications, 2022, 13: 4896. DOI: 10.1038/s41467-022-32641-1. Epub 2022 Aug 20.

155. Wei Liu, Liang Ma, Li-Ping Zhang, Yu-Chan Chen, Qing-Bo Zhang, Hai-Bo Zhang, Wei-Min Zhang, Changsheng Zhang*, Wen-Jun Zhang*. Two new phenylhydrazone derivatives from the Pearl River estuary sediment-derived Streptomyces sp. SCSIO 40020. Marine Drugs, 2022, 20 (7): 449. DOI: 10.3390/md20070449. Epub 2022 Jul 09.

154. ZHANG Haibo, Imran Khan, Kumar Saurav, FANG Zhuangjie, ZHANG Xinya, PENG Fang, ZHANG Changsheng. Bioactive natural compounds from Antarctic-derived fungus Penicillium sp. S2014503 [in Chinese]. Journal of Tropical Oceanography (热带海洋学报), 2023, 42 (2): 132-140. DOI: 10.11978/2022074. Epub 2022 May 16.

153. ZHU Yiguang, MOU Pengyun, ZHANG Qingbo, ZHANG Changsheng. Study on the secondary metabolites from the South China Sea derived fungus Penicillium sp. SCSIO 40438 [in Chinese]. Journal of Tropical Oceanography (热带海洋学报), 2022, DOI: 10.11978/2022079. Epub 2022 May 10.

152. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal Macrolides Kongjuemycins from Coral-associated Rare Actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487. DOI: 10.1021/acs.orglett.2c01089. (selected as Supplementary cover article) Epub 2022 April 27.

            

151. Ting Long, Qingbo Zhang, Pengyun Mou, Junfeng Wang, Changsheng Zhang, Yiguang Zhu. Discovery and characterization of a PKS-NRPS hybrid in Arthrinium arundinis ZSDS1-F3 by genome mining [in Chinese]. Acta Microbiologica Sinica (微生物学报), 2022, 62 (8): 3224-3235. DOI:  10.13343/j.cnki.wsxb.20210783. Epub 2022 Apr 21.

150. Lu Wang, Weixia Ye, Mengran Zhao, Qingbo Zhang, Liping Zhang, Changsheng Zhang, Wenjun Zhang*. Species diversity of culturable endophytic fungi from Zhanjiang mangrove forests and study on the secondary metabolites of Stemphyliums sp. SCSIO 40436 [in Chinese]. Mcirobiology China (微生物学通报), 2022, 49 (8): 2995-3007. DOI: 10.13344/j.microbiol.china.211223. Epub 2022 Apr 01.

149. Mengran Zhao, Lu Wang, Weixia Ye, Wenjun Zhang, Qingbo Zhang, Liang Ma, Liping Zhang, Changsheng Zhang, Chunfang Yang*. Diversity of actinobacteria from mangrove sediment in Gaoqiao Zhanjiang and identification of germicidins from one of the Streptomyces [in Chinese]. Acta Microbiologica Sinica (微生物学报), 2022, 62 (5): 1740-1753. DOI: 10.13343/j.cnki.wsxb.20210531; CNKI. Epub 2022 Feb 23.

148. Huixin Xu, Lu Wang, Liping Zhang, Wei Liu, Qingbo Zhang, Haibo Zhang, Changsheng Zhang, Wenjun Zhang*. Configurational assignment of malfilamentoside A and a new furanone glycoside malfilamentoside D. Chines Journal of Organic Chemistry (有机化学)，2022, DOI: 10.6023/cjoc2021110038. Epub 2021 Dec 30.

147. Weixia Ye, Mengrang Zhao, Lu Wang, Xiaodong Jiang, Wenjun Zhang, Changsheng Zhang, Haiyan Tian*. Isolation, identification and bioactive metabolites of coral-derived fungus Aspergillus sp. SCSIO 40435 from the South China Sea [in Chinese]. Acta Microbiologica Sinica (微生物学报), 2022, 62 (5): 1819–1831. DOI: 10.13343/j.cnki.wsxb.20210568; CNKI. Epub 2021 Nov 25.


2021

146. Xiao-Zhen Wu, Wen-Jun Huang, Wei Liu, Attila Mándi, Qingbo Zhang, Liping Zhang, Wenjun Zhang, Tibor Kurtán, Cheng-Shan Yuan*, Changsheng Zhang*. Penicisteckins A‒F, isochroman-derived atropisomeric dimers from Penicillium steckii HNNU-5B18. Journal of Natural Products, 2021, 84 (11): 2953–2960. DOI: 10.1021/acs.jnatprod.1c00787. Epub 2021 Nov 17.

145. Ruoxuan Bao#, Yongmei Meng#, Haibo Zhang, Chen Yang, Wei Li, Cheng Zhang, Jinye Zhang, Renqiang Sun, Zengxia Li, Wei Jiang, Chensong Zhang, Changsheng Zhang*, Hai-Xin Yuan*, Yongjun Dang*. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death & Disease, 2021,12, Article number: 972. DOI: 10.1038/s41419-021-04264-9. Epub 2021 Oct 20.

144. Bidhan Chandra De, Wenjun Zhang, Guangtao Zhang, Zhiwen Liu, Bin Tan, Qingbo Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Host-dependent heterologous expression of berninamycin gene cluster leads to linear thiopeptide antibiotics. Organic & Biomolecular Chemistry, 2021, 19 (41): 8940-8946. DOI:  10.1039/D1OB01759D. Epub 2021 Oct 1. ("Hot off the press" in Natural Product Reports, 2021, 38 (12): 2139-2144.DOI: 10.1039/D1NP90046C). Themed collection 2021 Organic & Biomolecular Chemistry HOT article collection.

143. Shilan Zhai, Wei Liu, Zhengchao Wu, Yiguang Zhu, Wenjun Zhang, Changsheng Zhang, Liang Ma*. Identification of bafilomycins and heterologous expression of its biosynthetic gene cluster from the Pearl River Estuary sediment-derived Streptomyces sp. SCSIO 40020 [in Chinese]. Acta Microbiologica Sinica (微生物学报), 2021, 61 (12): 3991-4005. abstract DOI: 10.13343/j.cnki.wsxb.20210121. Epub 2021 Sept 14.

142. Haibo Zhang, Liping Zhang, Imran Khan, Guangtao Zhang, Yiguang Zhu & Changsheng Zhang*. A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds. SCIENCE CHINA Chemistry, 2021, 64 (10): 1736–1742. DOI: 10.1007/s11426-021-1072-6. Epub 2021 Aug 31.

141. Chunshuai Huang, Chunfang Yang*. Wenjun Zhang, Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Discovery of an unexpected 1,4-oxazepine-linked seco-fluostatin heterodimer by inactivation of the oxidoreductase-encoding gene flsP. Journal of Natural Products, 2021,  84 (8): 2336–2344. DOI: 10.1021/acs.jnatprod.1c00461. Epub 2021 Aug 12.

140. Lu Wang#, Yanbing Huang#, Liping Zhang, Zhiwen Liu, Wei Liu, Huixin Xu, Qingbo Zhang, Haibo Zhang, Yan Yan, Zhiyong Liu, Tianyu Zhang, Wenjun Zhang*, Changsheng Zhang*. Structures and absolute configurations of phomalones from coral-associated fungus Parengyodontium album sp. SCSIO 40430.  Organic & Biomolecular Chemistry, 2021, 19 (27): 6030-6037. DOI: 10.1039/d1ob00869b. Epub 2021 Jun 29.

139. Pengyun Mou, Qingbo Zhang, Jing Peng, Xiaodong Jiang, Liping Zhang, Zhongbo Zhou*, Changsheng Zhang, Yiguang Zhu*. Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Fitoterapia, 2021, 152: 104937. DOI: 10.1016/j.fitote.2021.104937. Epub 2021 May 15.

138. JIN Hongbo, ZHANG Liping, ZHANG Wenjun, ZHANG Guangtao, ZHU Yiguang, LIU Wei, ZHANG Changsheng*. In Vitro biochemical characterization of ikarugamycin oxidase CftA [in Chinese]. Mcirobiology China (微生物学通报), 2021, 48 (7): 2389-2397. DOI:  10.13344/j.microbiol.china.210150. Epub 2021 Apr 27.

137. Xiaodong Jiang, Zhuangjie Fang, Qingbo Zhang*, Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247. DOI: 10.1039/d1ob00310k. Epub 2021 Apr 22. ("Hot off the press" in Natural Product Reports, 2021, 38 (8): 1418-1422. DOI: 10.1039/D1NP90030G)

136. Jing Peng, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Ting Long, Ziqian Cheng, Changsheng Zhang*, Yiguang Zhu*. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research, 2022, 36 (10): 2458-2464. DOI:  10.1080/14786419.2021.1901699. Epub 2021 Mar 19.

135. Xinya Zhang#, Siqiang Chen#, Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang*, and Changsheng Zhang*. Dassonmycins A and B, Polycyclic thioalkaloids from a marine sponge-derived Nocardiopsis dassonvillei SCSIO 40065. Organic Letters, 2021, 23 (8): 2858–2862. DOI: 10.1021/acs.orglett.1c00328. ( Front Cover paper ). Epub 2021 Mar 11. ("Hot off the press" in Natural Product Reports, 2021, 38 (6): 1053-1057. DOI: 10.1039/D1NP90020J).

          
134. Imran Khan, Jing Peng, Zhuangjie Fang, Wei Liu, Wenjun Zhang, Qingbo Zhang, Liang Ma, Guangtao Zhang, Changsheng Zhang*, and Haibo Zhang.* Cylindromicin from arctic-derived fungus Tolypocladium sp. SCSIO 40433. Molecules, 2021, 26(4): 1080. DOI: 10.3390/molecules26041080. Epub 2021 Feb 18.

133. Hui-Xin Xu, Ting Yang, Li-Ping Zhang, Wei Liu, Hai-Bo Zhang, Qing-Bo Zhang, Chang-Sheng Zhang*, Wen-Jun Zhang*. Ocauxarthrol A from Auxarthron umbrinum SCSIO 40432 and configurational reassignment of chrysoqueen and auxarthrols. Tetrahedron Letters, 2021, 66: 152842. DOI:  10.1016/j.tetlet.2021.152842. Epub 2021 Feb 4.

132. Chunfang Yang,# Chunshuai Huang,# Chunyan Fang, Liping Zhang, Siqiang Chen, Qingbo Zhang, Changsheng Zhang*, Wenjun Zhang*. Inactivation of flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis leads to diversified angucyclinone derivatives. Journal of Organic Chemistry, 2021,  86 (16): 11019–11028. DOI: 10.1021/acs.joc.0c02517. (Supplementary cover article) ("Hot off the press" in Natural Product Reports, 2021,  DOI: 10.1039/d1np90037d). Epub 2021 Feb 3.

https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/joceah/2021/joceah.2021.86.issue-16/acs.joc.0c02517/20210812/images/medium/jo0c02517_0005.gif

131. Liang Ma, Wenjun Zhang, Zhiwen Liu, Yanbing Huang, Qingbo Zhang, Xinpeng Tian, Changsheng Zhang, Yiguang Zhu*. Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment,  producing diverse bioactive natural products. Marine Genomics, 2021, 55: 100803. DOI: 10.1016/j.margen.2020.100803. Epub 2020 Jul 9.

130. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194. DOI: 10.1080/14786419.2019.1616729 .Epub 2019 May 29.



2020


129. Siqiang Chen, Qingbo Zhang, Xinya Zhang, Xiaodong Jiang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang, and Liping Zhang*. A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064. Natural Product Research, 2022, 36 (14): 3529-3537. DOI: 10.1080/14786419.2020.1867131. Epub 2020 Dec 30.

128. Chunyan Fang, Yiguang Zhu, Changsheng Zhang, and Qingbo Zhang*. The study of secondary metabolites from the PPtase overexpressed marine-derived actinomycete Streptomyces sp. SCSIO 40060 [in Chinese]. Chinese Journal of Marine Drugs (中国海洋药物), 2020, 39 (6): 12-18.  HTML Epub 2020 Dec 15.

127. Liping Zhang#, Bidhan Chandra De#, Wenjun Zhang*, Attila Mándi, Zhuangjie Fang, Chunfang Yang, Yiguang Zhu, Tibor Kurtán, and Changsheng Zhang.* Mutation of an atypical oxirane oxyanion hole improves regioselectivity of the α/β-fold epoxide hydrolase Alp1U. Journal of Biological Chemistry, 2020, 295 (50): 16987-16997. DOI: 10.1074/jbc.RA120.015563 . Epub 2020 Oct 1.

126. Zhuangjie Fang#, Xiaodong Jiang#, Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang*.S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130. DOI: 10.1021/acs.jnatprod.0c00719. Epub 2020 Sep 24.

125. Jinxin Xu#*, Xiaowen Tang#, Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu*. Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition. Communications Biology, 2020, 3(1): 455. DOI: 10.1038/s42003-020-01184-w. Epub 2020 Aug 19.

124. Imran Khan, Haibo Zhang*, Wei Liu,  Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, and Changsheng Zhang*. Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019.  RSC Advances, 2020, 10 (35): 20738-20744. DOI:  10.1039/D0RA03529G. Epub 2020 Jun 2.

123. Ling Liu, Sainan Li, Runze Sun, Xiangjing Qin, Jianhua Ju, Changsheng Zhang, Yanwen Duan*, and Yong Huang*. Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Organic Letters, 2020, 22 (12): 4614–4619. DOI: 10.1021/acs.orglett.0c01224. Epub 2020 May 28.

122. Yuanqi Wang, Changsheng Zhang, Yilei Zhao*, Rosalinda Zhao, Kendall Houk.  Understand the specific regio- and enantioselectivity of fluostatin  conjugation in the post-biosynthesis. Biomolecules, 2020, 10 (6): 815. DOI: 10.3390/biom10060815. Epub 2020 May 26.

121. Yiguang Zhu#, Qingbo Zhang#, Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu*, and Changsheng Zhang*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069. DOI: 10.1002/anie.202004978 and 10.1002/ange.202004978. Epub 2020 Apr 23.


120. Wei Liu#, Vinay Gopal Jannu#, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang*, and Yiguang Zhu.* Heterologous expression of the trichostatin gene cluster and functional characterization of the N-methyltransferase TsnB8. Organic & Biomolecular Chemistry, 2020, 18 (19): 3649-3653. DOI: 10.1039/d0ob00617c. Epub 2020 Apr 23.

119. Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan*, and Shoudeng Chen*. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharmaceutica Sinica B (APSB), 2020, 10 (7): 1228-1238. DOI: 10.1016/j.apsb.2020.04.009. Epub 2020 Apr 20.

118. Chunyan Fang, Qingbo Zhang, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Liang Ma, Haibo Zhang, and  Changsheng Zhang*. Proximicins F and G and diproximicin A: aminofurans from the marine-derived Verrucosispora sp. SCSIO 40062 by overexpression of PPtase genes. Journal of Natural Products, 2020, 83 (4): 1152-1156. DOI:  10.1021/acs.jnatprod.9b01185. Epub 2020 Mar 19.


117. Bin Tan#, Qingbo Zhang#, Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides.  ACS Chemical Biology, 2020, 15 (3): 766-773. DOI: 10.1021/acschembio.9b00997.  Introducing Our Authors for Bin Tan (DOI: 10.1021/acschembio.0c00202). Epub 2020 Mar 9.

116. Mahder S. Manenda, Marie-Ève Picard, Liping Zhang, Normand Cyr, Xiaojun Zhu, Julie Barma, Manon Couture, Changsheng Zhang, and Rong Shi*. Structural analyses of the group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. Journal of Biological Chemistry, 2020, 295 (14): 4709-4722. DOI:  10.1074/jbc.RA119.011212. Epub 2020 Feb 28.

115. Hongbo Jin, Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, and Changsheng Zhang*. Engineered biosynthesis of 5/5/6 type polycyclic tetramate macrolactams in an ikarugamycin (5/6/5 type)-producing chassis.  Organic Letters, 2020, 22 (5): 1731-1735. DOI: 10.1021/acs.orglett.9b04672. Epub 2020 Feb 13. ("Hot off the press" in Natural Product Reprots, 2020, 37 (4): 472-476. DOI: 10.1039/D0NP90014A) 

114. Bin Tan#, Siqiang Chen#, Qingbo Zhang*, Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066. DOI: 10.1021/acs.orglett.9b04597.  Epub 2020 Jan 23.


113. Liang Ma, Qingbo Zhang, Chunfang Yang, Yiguang Zhu, Liping Zhang, Lijuan Wang, Zhiwen Liu, Guangtao Zhang, and Changsheng Zhang*. Assembly line and post-PKS modifications in the biosynthesis of marine polyketide natural products. Book chapter in: Comprehensive Natural Products III: Chemistry and Biology. Book editor, Begley, T. P. & H.-w. Liu; Volume editor, Y. Tang, 2020, Volume 1: 139-197. DOI: 10.1016/B978-0-12-409547-2.14711-0. Epub 2019 Nov 23.


2019


112. Wei Liu, Wenjun Zhang, Hongbo Jin, Qingbo Zhang, Yuchan Chen, Xiaodong Jiang, Guangtao Zhang, Liping Zhang, Weimin Zhang, Zhigang She, and Changsheng Zhang.* Genome mining of marine-derived Streptomyces sp. SCSIO 40010 leads to cytotoxic new polycyclic tetramate macrolactams. Marine Drugs, 2019, 17 (12): 663. DOI: 10.3390/md17120663. Epub 2019 Nov 25. ( See also in the printed book, "Genome Mining and Marine Microbial Natural Products",  Kui Hong, Changsheng Zhang, Alan Dobson  (Eds.). ISBN 978-3-03928-090-2 (Pbk); ISBN 978-3-03928-091-9 (PDF)

         

111. Liujuan Zheng,# Xiaodong Jiang,# Qingbo Zhang, Yiguang Zhu, Haibo Zhang, Wenjun Zhang, Kumar Saurav, Jinsong Liu, and Changsheng Zhang.* Discovery and biosynthesis of neoenterocins indicate a skeleton rearrangement of enterocin. Organic Letters, 2019, 21 (22): 9066-9070. DOI: 10.1021/acs.orglett.9b03460. Epub 2019 Oct 28. ("Hot off the press" in Natural Product Reprots, 2020, 37 (2): 145-149. DOI: 10.1039/D0NP90004D) 

110. Ziquan Yu, Haibo Zhang, Chengshan Yuan, Qingbo Zhang, Imran Khan, Yiguang Zhu, and Changsheng Zhang.* Characterizing two cytochrome P450s in tiacumicin biosynthesis reveals reaction timing for tailoring modifications. Organic Letters, 2019, 21 (18): 7679-7683.  DOI: 10.1021/acs.orglett.9b03100. Epub 2019 Sep 11. ("Hot off the press" in Natural Product Reprots, 2019, 36 (12): 1614-1618. DOI: 10.1039/C9NP90045D) 

109. Chunshuai Huang, Chunfang Yang, Zhaungjie Fang, Liping Zhang, Wenjun Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of stealthin derivatives and Implication of the amidotransferase FlsN3 in the biosynthesis of nitrogen-containing fluostatins. Marine Drugs, 2019, 17 (3): 150. DOI: 10.3390/md17030150. Epub 2019 Mar 4.

 

108. Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Yiguang Zhu, Liang Ma, Zhuangjie Fang, and Changsheng Zhang*. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster. The Journal of Antibiotics, 2019, 72 (5): 311-315. DOI: 10.1038/s41429-019-0161-4. Epub 2019 Feb 28.

107. Zhiwen Liu,# Liang Ma,# Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang, and Changsheng Zhang*. Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers. Organic & Biomolecular Chemistry, 2019, 17 (5): 1053-1057. Epub 2018 Dec 6. DOI:  10.1039/C8OB02775G (contribution to the themed collection: "Biosynthesis" as an outside front cover. PDF)

             


2018

106. Chunshuai Huang, Chunfang Yang, Yiguang Zhu*, Wenjun Zhang, Cheng-shan Yuan, and Changsheng Zhang*. Marine bacterial aromatic polyketides from host-dependent heterologous expression and fungal mode of cyclization. Frontiers in Chemistry, 2018, 6 (10): 528. DOI: 10.3389/fchem.2018.00528. Epub 2018 Oct 30. (contribution to section Medicinal and Pharmaceutical Chemistry of research topic "Natural Products from Marine Microorganisms")

105. Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, Xiaodong Jiang, Hongbo Jin, Zhiwen Liu, Haibo Zhang, Aihua Zhou, Changsheng Zhang*.  New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060. Tetrahedron, 2018, 74 (47): 6839-6845. DOI: 10.1016/j.tet.2018.10.007. Epub 2018 Oct 11.

104. HUANG Yan-bing, JIANG Xiao-dong, LIU Wei, HUANG Chun-shuai, ZHANG Li-ping, ZHU Han-ning, ZHANG Chang-sheng, ZHANGWen-jun*. Study on chromanones from Montipora foliosa-derived Parengyodontium album SCSIO 40430 [in Chinese]. Microbiology China (微生物学通报), 2018, 45 (9): 1881-1888. DOI: 10.13344/j.microbiol.china.180226. Epub 2018 Jun 6.

103.  Changsheng Zhang, Wenli Li. Marine Microbiology: new opportunities and new challenges [in Chinese]. Microbiology China (微生物学通报), 2018, 45(9): 1841-1842. DOI: 10.13344/j.microbiol.china.189009. Epub 2018 Sep 20.


102. Chunshuai Huang,# Chunfang Yang,# Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu*, Changsheng Zhang*.  Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.  Nature Communications, 2018, 9 (1): 2088. DOI: 10.1038/s41467-018-04487-z. Epub 2018 May 25. (Featured in a Nature Communications  Editors' Highlights Webpage of recent research on Organic Chemistry and Chemical Biology by Julia Eckhoff)

101. Haibo Zhang, Xiaoxing Tian, Xiaohui Pu, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang*.  Tiacumicin congeners with improved antibacterial activities from a halogenase-inactivated mutant. Journal of Natural Products, 2018, 81 (5): 1219–1224. DOI: 10.1021/acs.jnatprod.7b00990. Epub 2018 Apr 20.

100. Wei Lin,# Kalyan Das,# David Degen,# Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard Y. Ebright, Elena Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, Zhening Zhang, Edward T. Eng, Dennis Thomas, Stefano Donadio, Haibo Zhang, Changsheng Zhang, Achillefs N. Kapanidis, Richard H. Ebright*. Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3). Molecular Cell, 2018, 70 (1): 60-71. DOI: 10.1016/j.molcel.2018.02.026. Epub 2018 Mar 29.


2017

99. Ruidong Chen,# Qingbo Zhang,# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700. DOI: 10.1021/acs.orglett.7b02878. Epub 2017 Oct 11.

98. Liang Ma, Wenjun Zhang, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Qingbo Zhang, Liping Zhang, Chengshan Yuan & Changsheng Zhang*. Identification and characterization of a gene cluster for tryptophan dimers in deep sea-derivedStreptomyces sp. SCSIO 03032. Applied Microbiology and Biotechnology, 2017, 101 (15): 6123–6136. DOI: 10.1007/s00253-017-8375-5. Epub 2017 Jun 15.

97. Qingbo Zhang,# Huixian Li,# Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu* and Changsheng Zhang*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077. DOI: 10.1039/C7SC01182B. ("Hot off the press" in Natural Product Reports, 2017, 34 (10): 1180-1184. DOI: 10.1039/C7NP90040F.  Epub 2017 May 4. Selected in Themed collection "In celebration of Chinese New Year", a special online collection of articles to celebrate Chinese New Year. This collection includes some of most popular articles from China and highlights a number of outstanding contributions)


96. TIAN Xiao-xing, KUMAR Saurav, ZHANG Qing-bo, ZHANG Wen-jun, PU Xiao-hui, ZHANG Chang-sheng, ZHANG Hai-bo*. Investigation on the Diketopiperazines Produced by Two Strains of Antarctic-derived Actinomycetes [in Chinese]. Chinese Journal of Marine Drugs (中国海洋药物), 2017, 36 (3): 67-72. Epub 2017 Jun 15.

95. Xiaodong Jiang, Qingbo Zhang, Yiguang Zhu, Fangling Nie, Zhengchao  Wu, Chunfang Yang, Liping Zhang, Xinpeng Tian, Changsheng Zhang*. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089. Tetrahedron, 2017, 73 (26): 3585–3590. DOI: 10.1016/j.tet.2017.03.054. Epub 2017 Mar 23. (Dedicated to the Tetrahedron Young Investigator Prize Special Issue in honor of Professor Ang Li).

94. Wenjun Zhang,# Chunfang Yang,# Chunshuai Huang, Liping Zhang, Haibo Zhang, Qingbo Zhang, Cheng-Shan Yuan, Yiguang Zhu, Changsheng Zhang*. Pyrazolofluostatins A-C,  pyrazole-fused nenzo[a]fluorenes from South China Sea-derived Micromonospora rosaria SCSIO N160. Organic Letters, 2017, 19 (3): 592–595.  DOI: 10.1021/acs.orglett.6b03745. Epub 2017 Jan 11. ("Hot off the press" in Natural Product Reports, 2017, 34 (4) : 338-342. DOI: 10.1039/C7NP90009K)

93. Subhasish Saha,# Wenjun Zhang,# Guangtao Zhang,# Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang, Changsheng Zhang.* Activation and characterization of a cryptic gene cluster reveal a cyclization cascade for polycyclic tetramate macrolactams. Chemical Science, 2017,8 (2): 1607-1612. DOI: 10.1039/C6SC03875A. Epub 2016 Oct 28.



2016

92. ZHENG Liu-juan, JIANG Xiao-dong, TAN Bin, YUAN Cheng-shan, ZHANG Chang-sheng, ZHANG Qing-bo*. The study of secondary metabolites from the marine-derived actinomycete Streptomyces sp. SCSIO BEMM34 [in Chinese]. Chinese Journal of Marine Drugs (中国海洋药物), 2016, 35 (6): 38-45. Epub 2016 Dec 15.

91. Xinpeng Tian, Zhewen Zhang, Tingting Yang, Meili Chen, Jie Li, Fei Chen, Jin Yang, Wenjie Li, Bing Zhang, Zhang Zhang, Jiayan Wu, Changsheng Zhang, Lijuan Long,* Jingfa Xiao*. Comparative genomics analysis ofStreptomycesspecies reveals their adaptation to the marine environment and their diversity at the genomic level. Frontiers in Microbiology, 2016, 10.3389/fmicb.2016.00998. Epub 2016 Jun 27.
90. Haibo Zhang,# Kumar Saurav,# Ziquan Yu, Attila Mándi, Tibor Kurtán, Jie Li, Xinpeng Tian, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang*. α-Pyrones with diverse hydroxy substitutions from three marine-derived Nocardiopsis strains. Journal of Natural Products, 2016, 79(6): 1610–1618. DOI: 10.1021/acs.jnatprod.6b00175. Epub 2016 Jun 14.

89. Yiguang Zhu,# Marie-Ève Picard,# Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu, Rong Shi* and Changsheng Zhang.*  Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis. Chemical Science, 2016,7(8): 4867-4874. DOI: 10.1039/c6sc00771f. Epub 2016 Apr 13.

Graphical abstract: Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis


88. Yiguang Zhu,# Jinxin Xu,# Xiangui Mei,# Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu,* Jinsong Liu,* Changsheng Zhang*. Biochemical and structural insights into the aminotransferase CrmG in caerulomycin biosynthesis. ACS Chemical Biology, 2016,11 (4): 943–952. DOI: 10.1021/acschembio.5b00984. Epub 2016 Jan 12.


87. Guangtao Zhang, Wenjun Zhang, Subhasish Saha, Changsheng Zhang*. Recent advances in discovery, biosynthesis and genome mining of medicinally relevant polycyclic tetramate macrolactams. Current Topics in Medicinal Chemistry, 2016, 16 (15): 1727-1739. (invited review). DOI: 10.2174/1568026616666151012112818. Epub 2015 Oct 11.


2015

86. Chunfang Yang, Chunshuai Huang, Wenjun Zhang*, Yiguang Zhu, Changsheng Zhang*. Heterologous expression of fluostatin gene cluster leads to a bioactive heterodimer. Organic Letters, 2015, 17(21): 5324-5327. DOI:  10.1021/acs.orglett.5b02683.  Epub 2015 Oct 14. ("Hot off the press" in Natural Product Reports, 2016, 33(2): 122-126. DOI: 10.1039/C5NP90052B)

85. Medema MH*, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum information about a biosynthetic gene cluster. Nature Chemical Biology, 2015, 11(9): 625-631. DOI:  10.1038/nchembio.1890. Epub 2015 Aug 18.

84. NIE Fang-ling, CHEN Yu-chan, ZHANG Qing-bo, TIAN Xin-peng, ZHANG Wei-min, ZHANG Chang-sheng, ZHANG Wen-jun*. Aromatic Amide Metabolites from the Deep-sea-derived Streptomyces sp. SCSIO 03032 [in Chinese]. Chinese Journal of Marine Drugs (中国海洋药物), 2015, 34 (4): 49-55. Epub 2015 Aug 15.

83. Yiguang Zhu,# Wenjun Zhang,# Yaolong Chen, Chengshan Yuan, Haibo Zhang, Guangtao Zhang, Liang Ma, Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang*. Characterization of heronamide biosynthesis reveals a tailoring hydroxylase and indicates migrated double bonds. ChemBioChem, 2015, 16(14): 2086-2093. DOI: 10.1002/cbic.201500281. Epub 2015 Aug 6.


82. Huixian Li,# Yu Sun,# Qingbo Zhang, Yiguang Zhu, Shu-Ming Li, Ang Li, Changsheng Zhang*. Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations. Organic Letters, 2015, 17(2): 306-309. DOI: 10.1021/ol503399b. Epub 2014 Dec 22. ("Hot off the press" in Natural Product Reports, 2015, 32(4): 512-516. DOI: 10.1039/C5NP90013A)


2014


81. Wenjun Zhang, Liang Ma, Sumei Li, Zhong Liu, Yuchan Chen, Haibo Zhang, Guangtao Zhang, Qingbo Zhang, Xinpeng Tian, Chengshan Yuan, Si Zhang, Weimin Zhang, and Changsheng Zhang*. Indimicins A–E, Bisindole Alkaloids from the Deep Sea-Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products, 2014, 77 (8): 1887-1892. DOI: 10.1021/np500362p. Epub 2014 Aug 22. (Featured as "Key Drug Discovery Article" by Global Medical Discovery)


80. Peng Fu,# Yiguang Zhu,# Xiangui Mei, Yi Wang, Haijian Jia, Changsheng Zhang*, Weiming Zhu*. Acyclic Congeners fromActinoalloteichus cyanogriseusProvide Insights into Cyclic Bipyridine Glycoside Formation. Organic Letters, 2014, 16 (16): 4264-4267. DOI: 10.1021/ol5019757. Epub 2014 Aug 4.

79. Guangtao Zhang,# Wenjun Zhang,# Qingbo Zhang, Ting Shi, Liang Ma, Yiguang Zhu, Sumei Li, Haibo Zhang, Yi-Lei Zhao, Rong Shi, Changsheng Zhang*. Mechanistic Insights Into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis. Angewandte Chemie International Edition, 2014, 53 (19): 4840-4844. DOI:  10.1002/anie.201402078. Epub 2014 Apr 6. (Recommended by Faculty of 1000; "Hot off the press" in Natural Product Reports, 2014, 31 (9): 1083-1087. DOI: 10.1039/C4NP90023E).


78. Wenjun Zhang, Sumei Li, Yiguang Zhu, Yuchan Chen, Yaolong Chen, Haibo Zhang, Guangtao Zhang, Xinpeng Tian, Yu Pan, Si Zhang, Weimin Zhang, and Changsheng Zhang*. Heronamides D–F, Polyketide Macrolactams from the Deep-Sea Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products, 2014, 77(2): 388–391. DOI: 10.1021/np400665a. Epub 2014 Feb 18.


77. WU Zheng-chao, ZHENG Liu-juan, CHEN Yao-long, LI Jie, CHEN Yu-chan, ZHANG Wei-min, ZHANG Chang-sheng, LI Su-mei*. Isolation and elucidation of phenazine alkaloid antibiotics [in Chinese]. Chinese Journal of Marine Drugs (中国海洋药物), 2014, 33 (1): 45-52. Epub 2014 Feb 15.

76. Yaolong Chen,# Wenjun Zhang,# Yiguang Zhu,* Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang*. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis. Organic Letters, 2014, 16(3): 736-739. DOI: 10.1021/ol4034176. Epub 2014 Jan 10.




2013

75. Yiguang Zhu, Qingbo Zhang, Sumei Li, Qinheng Lin, Peng Fu, Guangtao Zhang, Haibo Zhang, Rong Shi, Weiming Zhu*, and Changsheng Zhang*. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. Journal of the American Chemical Society, 2013, 135(50): 18750-18753. DOI: 10.1021/ja410513g. ("Hot off the press" in Natural Products Reports, 2014, 31(4): 414-418. DOI: 10.1039/c4np90007c). Epub 2013 Dec 5.


74. Liang Ma, Wenjun Zhang, Yiguang Zhu, Zhengchao Wu, Kumar Saurav, Hui Hang, Changsheng Zhang*. Isolation of culturable Actinobacteria associated with Soft Coral Nephthea sp. from Yongxing Island and two antibiotics produced by one of these strains Salinospora arenicola SH04 [in Chinese]. Acta Microbiologica Sinica (Wei Sheng Wu Xue Bao), 2013, 53 (10): 1061-1071. Epub 2013 Oct 4.

73. Ruidong Chen,# Haibo Zhang,# Gaiyun Zhang, Sumei Li, Guangtao Zhang, Yiguang Zhu, Jinsong Liu, and Changsheng Zhang*. Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase. Journal of the American Chemical Society, 2013, 135 (33): 12152–12155. DOI: 10.1021/ja401016e. Epub 2013 Aug 9. ("Hot off the press" in Natural Product Reports, 2013, 30 (12): 1462-1466. DOI: 10.1039/C3NP90036C)


72. Ji Xiao, Qingbo Zhang, Yiguang Zhu, Sumei Li, Guangtao Zhang, Haibo Zhang, Kumar Saurav & Changsheng Zhang*. Characterization of the Sugar-O-Methyltransferase LobS1 in Lobophorin Biosynthesis. Applied Microbiology and Biotechnology, 2013, 97 (20): 9043-9053. DOI: 10.1007/s00253-013-5083-7. Epub 2013 Jul 20.

71. Zhengchao Wu, Sumei Li, Jie Li, Yuchan Chen, Kumar Saurav, Qingbo Zhang, Haibo Zhang, Wenjun Zhang, Weimin Zhang, Si Zhang and Changsheng Zhang*. Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428. Marine Drugs, 2013, 11(6): 2113-2125. DOI: 10.3390/md11062113. Epub 2013 Jun 14.
70. Zheng-Chao Wu, Sumei Li, Sang-Jip Nam, Zhong Liu, and Changsheng Zhang. Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp. CNX037. Journal of Natural Products, 2013, 76 (4): 694–701. DOI: 10.1021/np400009a. Epub 2013 Apr 15.

69. 张文军，李苏梅，张海波，张庆波，张改云，张光涛，朱义广，张长生*。海洋来源小单孢菌Micromonospora rosaria SCSIO N160中大环内酯类化合物的分离鉴定。天然产物研究与开发, 2013, 25 (4): 466-469。Epub 2013 Apr 15.

68. Sumei Li,# Ji Xiao,# Yiguang Zhu, Guangtao Zhang, Chunfang Yang, Haibo Zhang, Liang Ma, and Changsheng Zhang*. Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase. Organic Letters, 2013, 15 (6): 1374-1377. DOI: 10.1021/ol400342e. Epub 2013 Feb 22.

67. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang *. New Diketopiperazine Derivatives from a Deep-Sea-Derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36. DOI: 10.1038/ja.2012.88. Epub 2012 Oct 24.
66. Xin-Peng Tian, Li-Juan Long, Su-Mei Li, Jing Zhang, Ying Xu , Jie He, Jie Li, Fa-Zuo Wang, Wen-Jun Li, Chang-Sheng Zhang, Si Zhang*. Pseudonocardia antitumoralis sp. nov., a new deoxynyboquinone-producing actinomycete isolated from a deep-sea sedimental sample in South China Sea. International Journal of Systematic and Evolutionary Microbiology, 2013, 63 (Pt 3):893-899. DOI: 10.1099/ijs.0.037135-0. Epub  2012 May 25.



2012


65. Lin Qinheng, Xiao Ji, Chen Ruidong, and Zhang Changsheng*. Progresses on the In Vitro Studies of Glycosyltransferases from Microbial Glycosidic Antibiotics [in Chinese]. Chinese Journal of Antibiotics (中国抗生素杂志), 2012, 37 (12): 881-895. DOI: 10.13461/j.cnki.cja.005109. Epub 2012 Dec 25.

64. Qingbo Zhang, Huixian Li, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145. DOI: 10.1021/ol302782u. Epub 2012 Dec 3. ("Hot off the press" in Natural Product Reports, 2013, 30 (4): 485-489. DOI: 10.1039/c3np90007j.)



63. Wenjun Zhang,# Zhong Liu,# Sumei Li, Yongzhi Lu, Yuchan Chen, Haibo Zhang†, Guangtao Zhang, Yiguang Zhu, Gaiyun Zhang, Weimin Zhang, Jinsong Liu, and Changsheng Zhang*. Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160. Journal of Natural Products, 2012, 75(11): 1937–1943. DOI: 10.1021/np300505y. Epub 2012 Nov 8.


62. 田新朋, 黄洪波, 朱义广, 张长生,* 鞠建华, 龙丽娟, 张偲。海洋放线菌资源与代谢产物及其组合生物合成研究进展 [in Chinese]。2012年工业生物技术发展报告，科学出版社，2012: 107-122. Epub 2012 Oct 15.

61. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,* Changsheng Zhang*.  N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012 (27): 5256-5262. DOI: 10.1002/ejoc.201200599. Epub 2012 Aug 13.


60. Xin-Peng Tian, Li-Juan Long, Su-Mei Li, Jing Zhang, Ying Xu, Jie He, Jie Li, Fa-Zuo Wang, Wen-Jun Li, Chang-Sheng Zhang, Si Zhang*. Streptomyces oceanisp. nov., a new obligate marine actinomycete isolated from a deep-sea sample of seep authigenic carbonate nodule in South China Sea. Antonie Van Leeuwenhoek, 2012 , 102 (2): 335-343. DOI: 10.1007/s10482-012-9743-x. Epub 2012 Jun 14.

59. Wenjun Zhang, Zhong Liu, Sumei Li, Tingting Yang, Qingbo Zhang, Liang Ma, Xinpeng Tian, Haibo Zhang, Caiguo Huang, Si Zhang, Jianhua Ju, Yuemao Shen, and Changsheng Zhang*. Spiroindimicins A–D: New Bisindole Alkaloids from a Deep-Sea Derived Actinomycete. Organic Letters, 2012, 14 (13): 3364-3367. DOI: 10.1021/ol301343n. Epub 2012 Jun 13. ("Hot off the press" in Natural Product Reports, 2012, 29: 1033-1037. DOI: 10.1039/c2np90033e.)

58. Yiguang Zhu,# Peng Fu,# Qinheng Lin, Guangtao Zhang, Haibo Zhang, Sumei Li, Jianhua Ju, Weiming Zhu*, and Changsheng Zhang*. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase. Organic Letters, 2012, 14 (11): 2666-2669. DOI: 10.1021/ol300589r. Epub 2012 May 16. ("Hot off the press" in Natural Product Reports, 2012, 29 (8): 829-833. DOI: 10.1039/C2NP90024F).


57. Huixian Li,# Qingbo Zhang,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang*. Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005. DOI: 10.1021/ja303004g. Epub 2012 May 16.


56. Xiao Ji, Zhang Guangtao, Zhu Yiguang, Zhang Changsheng*. Recent progress in biosynthesis of secondary metabolites from marine microorganisms [in Chinese]. Chinese Journal of Antibiotics (中国抗生素杂志), 2012, 37 (4): 241-253. DOI: 10.13461/j.cnki.cja.004981.  Epub 2012 Apr 25.

55. Ziming Chen, Zhihui Zheng, Hongbo Huang, Yongxiang Song, Xuelian Zhang, Junying Ma, Bo Wang, Changsheng Zhang, Jianhua Ju*. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg Med Chem Lett. 2012 May 1; 22 (9): 3332-3335. doi: 10.1016/j.bmcl.2012.02.106. Epub 2012 Mar 11.

54. LI Jun, ZHU Qinghua, ZHANG Yun, MA Junying, TIAN Xinpeng, LI Wenjun, ZHANG Changsheng, JU Jianhua*. Development of a genetic system of deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652 [in Chinese]. Chinese Journal of Antibiotics (中国抗生素杂志), 2012, 37 (2): 105-111. DOI: 10.13461/j.cnki.cja.004934. Epub 2012 Feb 25.

53. Junying Ma, Dianguang Zuo, Yongxiang Song, Bo Wang, Hongbo Huang, Yueliang Yao, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012 Mar 5; 13 (4): 547-552. DOI: 10.1002/cbic.201100700. Epub 2012 Feb 23.

52. HU Tao, ZHANG Guangtao, ZHU Yiguang, LI Sumei, ZHANG Hiabo, ZHANG Gaiyun, YNAG Xiaohong, JU Jianhua, ZHANG Changsheng*. Cloning，expression and characterization of the nucleotidylyltransferase gene -amiE in amicetin biosynthesis [in Chinese]. Acta Microbiologica Sinica (微生物学报)，2012, 52 (2): 214-220.  HTML. Epub 2012 Feb 4.

51. Hongbo Huang, Tingting Yang, Xiangmei Ren, Jing Liu, Yongxiang Song, Aijun Sun, Junying Ma, Bo Wang, Yun Zhang, Caiguo Huang, Changsheng Zhang, Jianhua Ju*. Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. Journal of Natural Products, 2012 Feb 24;75 (2): 202-208. DOI: 10.1021/np2008335. Epub 2012 Feb 3.

50. Xuhua Mo, Junying Ma, Hongbo Huang, Bo Wang, Yongxiang Song, Si Zhang, Changsheng Zhang, Jianhua Ju*. Δ(11,12) double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. Journal of the American Chemical Society, 2012 Feb 15;134 (6): 2844-2847. DOI: 10.1021/ja206713a. Epub 2012 Feb 1.

49. Gaiyun Zhang, Haibo Zhang, Sumei Li, Ji Xiao, Guangtao Zhang, Yiguang Zhu, Siwen Niu, Jianhua Ju, and Changsheng Zhang*. Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation. Applied and Environmental Microbiology, 2012, 78 (7): 2393-2401. DOI: 10.1128/AEM.07185-11. Epub 2012 Jan 20.

48. Qinghua Zhu, Jun Li, Junying Ma, Minghe Luo, Bo Wang, Hongbo Huang, Xinpeng Tian, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from the deep-sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrobial Agents and Chemotherapy, 2012 Jan; 56 (1): 110-114. DOI: 10.1128/AAC.05278-11. Epub 2011 Nov 7.

47. Jie Li, Guang-Tao Zhang, Jian Yang, Xin-Peng Tian, Fa-Zuo Wang, Chang Sheng Zhang, Si Zhang*, Wen-Jun Li*. Marininema mesophilumgen. nov., sp. nov., a thermoactinomycete isolated from deep sea sediment, and emended description of the family Thermoactinomycetaceae. International Journal of Systematic and Evolutionary Microbiology, 2012, 62 (Pt 6): 1383-1388. DOI: 10.1099/ijs.0.035071-0. Epub 2011 Aug 5.

46. Xin-Peng Tian, Li-Juan Long, Fa-Zuo Wang, Ying Xu, Jie Li, Jing Zhang, Chang-Sheng Zhang, Si Zhang*, Wen-Jun Li*. Streptomyces nanhaiensis sp. nov., a marine streptomycete isolated from a deep-sea sediment. International Journal of Systematic and Evolutionary Microbiology, 2012, 62 (Pt 4): 864-868. doi: 10.1099/ijs.0.031591-0. Epub 2011 May 27.



2011


45. 陈子明，汪中文，黄洪波，陈玉婵，章卫民，张长生，鞠建华*。海洋真菌Xylaria sp.SOF11中细胞松弛素类化合物的研究。天然产物研究与开发， 2011, 23 (5): 801-804. Epub 2011 Oct 15.

44.  Hongbo Huang, Yueliang Yao, Zhengxiang He, Tingting Yang, Junying Ma, Xinpeng Tian, Yayong Li, Caiguo Huang, Xiaoping Chen, Wenjun Li, Si Zhang, Changsheng Zhang, Jianhua Ju*. Antimalarial beta-carboline and indolactam alkaloids from Marinactinosporathermotolerans, a deep sea isolate. Journal of Natural Products, 2011, 74 (10): 2122-2127.DOI: 10.1021/np200399t. Epub 2011 Oct 6.

43. Siwen Niu, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Weimin Zhang, Xiaohong Yang, Si Zhang, Jianhua Ju & Changsheng Zhang*. Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127. The Journal of Antibiotics, 2011, 64 (11):711-716. DOI: 10.1038/ja.2011.78. Epub 2011 Sep 7.

42. Sumei Li, Xinpeng Tian, Siwen Niu, Wenjun Zhang, Yuchan Chen, Haibo Zhang, Xianwen Yang, Weimin Zhang, Wenjun Li, Si Zhang, Jianhua Ju and Changsheng Zhang*. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Marine Drugs, 2011, 9 (8): 1428-1439. DOI: 10.3390/md9081428. Epub 2011 Aug 23.

41.  任香梅，黄洪波，刘 静，张 云，马俊英，王 博，张长生，鞠建华*。海洋链霉菌Streptomyces lusitanus SCSIO 32中芳酰胺类代谢产物的研究。天然产物研究与开发， 2011, 23 (4): 591-595. Epub 2011 Aug 15.

40. 林钦恒, 张光涛, 李苏梅, 张海波, 鞠建华, 朱伟明, 张长生*。浅蓝霉素产生菌海洋异壁放线菌WH1-2216-6 遗传操作体系的建立。微生物学报，2011, 51 (8): 1032-1041. Epub 2011 Aug 4.

39. Junying Ma, Zhongwen Wang, Hongbo Huang, Minghe Luo, Dianguang Zuo, Bo Wang, Aijun Sun, Yi-Qiang Cheng, Changsheng Zhang, Jianhua Ju*. Biosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. AngewandteChemie International Edition, 2011, 50 (34): 7797-7802. DOI: 10.1002/anie.201102305. Epub 2011 Jul 1.

38. 牛四文, 李苏梅, 田新朋, 胡涛, 鞠建华, 杨晓红, 张偲, 张长生*。海洋放线菌Streptomyces sp. SCSIO 1934中次生代谢产物的分离和鉴定。中国中药杂志，2011, 36 (13): 1763-1768.37. Epub 2011 Jul 1.

37.  周俊勇, 黄洪波, 汪中文, 杨民和, 田新朋, 张偲, 张长生, 鞠建华*。海洋链霉菌Streptomyces sp.SCSIO 1667中吲哚咔唑生物碱类成分的研究。天然产物研究与开发，2011, 23(3): 415-419. DOI:10.16333/j.1001-6880.2011.03.043. Epub 2011 Jun 15.

36.  Siwen Niu,# Tao Hu,# Sumei Li, Yi Xiao, Liang Ma, Guangtao Zhang, Haibo Zhang, Xiaohong Yang, Jianhua Ju, Changsheng Zhang*. Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity. ChemBioChem, 2011, 12(11): 1740-1748. DOI: 10.1002/cbic.201100129. Epub 2011 Jun 1.

35. Xuhua Mo, Hongbo Huang, Junying Ma, Zhongwen Wang, Bo Wang, Si Zhang, Changsheng Zhang, Jianhua Ju*. Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Organic Letters, 2011, 13 (9): 2212-2215. DOI: 10.1021/ol200447h. Epub 2011 Apr 1.

34. Xuhua Mo, Zhongwen Wang, Bo Wang, Junying Ma, Hongbo Huang, Xinpeng Tian, Si Zhang, Changsheng Zhang, Jianhua Ju*. Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochemical and Biophysical Research Communications, 2011, 406 (3): 341-347. DOI: 10.1016/j.bbrc.2011.02.040. Epub 2011 Feb 15.

33. LI Su-mei, TIAN Xin-peng, NIU Si-wen, ZHANG Wen-jun, ZHANG Si, JU Jian-hua, ZHANG Chang-sheng*. Isolation and structural elucidation of antimycins from marine Streptomyces sp. SCSIO 1635 from the South China Sea. Natural Product Research and Development, 2011, 23(1): 10-14. DOI: 10.16333/j.1001-6880.2011.01.037. Epub 2011 Feb 15.

32. Yi Xiao, Sumei Li, Siwen Niu, Liang Ma, Guangtao Zhang, Haibo Zhang, Gaiyun Zhang, Jianhua Ju, and Changsheng Zhang*. Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase. Journal of the American Chemical Society, 2011, 133 (4): 1092–1105. DOI: 10.1021/ja109445q. Epub 2010 Dec 27. ("Hot off the press" in Natural Product Reports, 2011, 28: 659-662. DOI: 10.1039/C1NP90009A.)

31. Liping Gong, Yi Xiao, Qiang Liu, Sumei Li, Changsheng Zhang,* Jinsong Liu*.  Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2011, 67(1): 136-139. DOI: 10.1107/S1744309110048268. Epub 2010 Dec 23.

30. Gavin J Williams, Jie Yang, Changsheng Zhang, Jon S Thorson*. Recombinant E. coli Prototype Strains for in Vivo Glycorandomization. ACS Chemical Biology, 2011, 6(1): 94-100. DOI: 10.1021/cb100267k. Epub 2010 Oct 22.


2010

29. 张偲*，张长生，田新朋，王发左，李洁。中国海洋微生物多样性研究。中国科学院院刊，2010, 25(6)：651-658。Epub 2010 Nov 15.

28. Duan Chuan-ren, YAO Yue-liang, WANG Zhong-wen, TIAN Xin-peng, ZHANG Si, ZHANG Chang-sheng, JU Jian-hua. Fermentation optimization, isolation and identification of tirandamycins A and B from marine-derived Streptomyces sp. SCSIO 1666 [in Chinese]. Chinese Journal of Marine Drugs, 2010, 29 (6): 12-20. Epub 2010 Dec 28.

27. LUO Ming-he, WANG Zhong-wen, HUANG Hong-bo, ZHU Qing-hua, TIAN Xin-peng, BAI Zhi-Chuan, ZHANG Si, ZHANG Chang-sheng, JU Jian-hua. Isolation and identification of Marine Strain Streptomyces sp. SCSIO 1672 and its metabolite salicylic acid [in Chinese. Journal of Microbiology, 2010, 30 (6): 22-26. Epub 2010 Nov 15.

26.  肖毅, 李苏梅, 马亮, 张改云, 鞠建华, 张长生*。台勾霉素生产菌指孢囊菌NRRL 18085遗传操作体系的建立。微生物学报, 2010, 50 (8): 1014-1022. DOI: 10.13343/j.cnki.wsxb.2010.08.005. Epub 2010 Aug 4.

25. 张长生*，鞠建华，龙丽娟，张偲。海洋微生物资源的开发和工业应用。2010工业生物技术发展报告，科学出版社，2010: 77-89。Epub 2010 Jul 1.


2009

24. Su-Mei Li , Xian-Wen Yang, Yong-Li Li, Yun-Heng Shen, Lin Feng, Yue-Hu Wang, Hua-Wu Zeng, Xiao-Hua Liu, Chang-Sheng Zhang, Chun-Lin Long, Wei-Dong Zhang.* Chemical constituents of Dracocephalum forresti. Planta Medica, 2009, 75 (15):1591-6. DOI: 10.1055/s-0029-1185868. Epub 2009 Dec.

Postdoctoral and Graduate (2002-2008)

23. Changsheng Zhang, Rocco Moretti, Jiqing Jiang, Jon S Thorson*. The In Vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI. ChemBioChem, 2008, 9(15): 2506-2514. DOI: 10.1002/cbic.200800349. Epub 2008 Oct 6.

22. Changsheng Zhang, Eduard Bitto, Randal D Goff, Shanteri Singh, Craig A Bingman, Byron R Griffith, Christoph Albermann, George N Phillips Jr,* Jon S Thorson*. Biochemical and Structural Insights of the Early Glycosylation Steps in Calicheamicin Biosynthesis. Chemistry and Biology, 2008, 15(8): 842-853. DOI: 10.1016/j.chembiol.2008.06.011.Epub 2008 Aug 22.

21. Shanteri Singh, Jason G McCoy, Changsheng Zhang, Craig A Bingman, George N Phillips Jr,* Jon S Thorson RebM*. Structure and Mechanism of the Rebeccamycin Sugar 4-O-Methyltransferase RebM. Journal of Biological Chemistry, 2008, 283(33): 22628-22636. DOI: 10.1074/jbc.M800503200. Epub 2008 May 23.

20. Gavin J Williams, Randal D Goff, Changsheng Zhang, Jon S Thorson*. Optimizing glycosyltransferase specificity via ‘hot spot’ saturation mutagenesis presents a new catalyst for novobiocin glycorandomization. Chemistry and Biology, 2008, 15(4): 393-401.DOI: 10.1016/j.chembiol.2008.02.017. Epub 2008 Apr 18.

19. Gavin J Williams , Changsheng Zhang, Jon S Thorson*. Expanding the Promiscuity of A Natural Product Glycosyltransferase by Directed Evolution. Nature Chemical Biology, 2007, 3(10): 657-662. DOI: 10.1038/nchembio.2007.28. Epub 2007 Sep 7. (Featured in Nature Chemical Biology, 2007, 3: 604; and Chemical & Engineering News, 2007, 85: 9; and reported in various press including: United Press International, Chemistry World, UW news, and Wisconsin State Journal, etc.)

18. Changsheng Zhang, Qiang Fu, Christoph Albermann, Lingjun Li, Jon S Thorson*. The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification. ChemBioChem, 2007, 8(4): 385-390. DOI: 10.1002/cbic.200600509. Epub 2007 Feb 19.

17. Changsheng Zhang, Christoph Albermann, Xun Fu, Jon S Thorson*. The In Vitro Characterization of the Iterative Avermectin Glycosyltransferase AveBI Reveals Reaction Reversibility and Sugar Nucleotide Flexibility. Journal of the American Chemical Society, 2006, 128(51): 16420-16421. DOI: 10.1021/ja065950k. Epub 2006 Dec 5.

16. Shanteri Singh, Martin H Hager, Changsheng Zhang, Byron R Griffith, Min S Lee, Klaas Hallenga, John L Markley, Jon S Thorson*. Structural insight into self-sacrifice mechanism of enediyne resistance. ACS Chemical Biology, 2006, 1(7): 451-460. DOI: 10.1021/cb6002898. Epub 2006 Aug 18.

15.Changsheng Zhang, Byron R Griffith, Qiang Fu, Christoph Albermann, Xun Fu, In-Kyoung Lee, Lingjun Li, Jon S Thorson*. Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. Science, 2006, 313(5791): 1291-1294. DOI: 10.1126/science.1130028. Epub 2006 Sep 1. (Featured in Nature,  ACS Chemical Biology,  Angewandte Chemie International Edition; highlighted in Nature, Nature Chemical Biology,  Nature Methods,  and Chemical & Engineering News, 2006, 84:13; and reported in various press including United Press International, Wisconsin State Journal, Wisconsin Technology Network, UW news, The Daily Cardinal, Milwaukee Journal Sentinel, etc.)

14. Qunjie Gao, Changsheng Zhang, Sophie Blanchard, Jon S Thorson*. Deciphering indolocarbazole and enediyne aminopentose biosynthesis through comparative genomics: New insights and tools from the Actinomadura melliaura AT2433 biosynthetic locus. Chemistry and Biology, 2006, 13(7):733-743. DOI: 10.1016/j.chembiol.2006.05.009. Epub 2006 Jul 28.

13. Changsheng Zhang, Christoph Albermann, Xun Fu, Noel R Peters, John D Chisholm, Guisheng Zhang, Eric J Gilbert, Peng George Wang, David L Van Vranken, Jon S Thorson*. RebG- and RebM-catalyzed Indolocarbazole Diversification. ChemBioChem, 2006, 7(5): 795-804. DOI: 10.1002/cbic.200500504. Epub 2006 Mar 31.

12. Svetlana A Borisova, Changsheng Zhang, Haruko Takahashi, Hua Zhang, Alexander W Wong, Jon S Thorson, Hung-wen Liu*. Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations and Mechanistic Hypotheses. Angewandte Chemie International Edition, 2006, 45(17): 2748-2753. DOI: 10.1002/anie.200503195. Epub 2006 Apr 11.

11. Changsheng Zhang, Rachel L Weller, Jon S Thorson, Scott R Rajski*. Natural Product Diversification Using Non-natural Cofactor Analogues of S-adenosyl-L-methionine.  Journal of the American Chemical Society, 2006, 128(9): 2760-2761. DOI: 10.1021/ja056231t. Epub 2006 Feb 10.

10.  Xun Fu, Christoph Albermann, Changsheng Zhang, Jon S Thorson*. Diversifying Vancomycin via Chemoenzymatic Strategies.Organic Letters, 2005, 7(8): 1513-1515. DOI: 10.1021/ol0501626. Epub 2005 Mar 18.

9.  Xun Fu, Christoph Albermann, Jiqing Jiang, Jianchun Liao, Changsheng Zhang, Jon S Thorson*. Antibiotic optimization via in vitro glycorandomization. Nature Biotechnology, 2003, 21(12): 1467-1469. DOI: 10.1038/nbt909. Epub 2003 Nov 9.

8.  Chang-Sheng Zhang, Michael Podeschwa, Oliver Block, Hans-Josef Altenbach, Wolfgang Piepersberg, Udo F Wehmeier*. Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanessp. SE50/110. FEBS Letters, 2003, 540(1-3): 53-57. DOI: 10.1016/s0014-5793(03)00222-9. Epub 2003 Mar 20.

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