蛋白磷酸化是重要的转录后修饰过程之一。蛋白激酶通过磷酸化调控底物蛋白的稳定性、活性、定位等性质，参与了几乎所有的生物学过程。相对于其它生物基因组，植物基因组中有更多的基因编码蛋白激酶，可能与植物细胞中更复杂的信号感受和转导机制有关。已知MAPK、CDPK、SnRK2/3等多个蛋白激酶家族参与了植物对于干旱、渗透胁迫、盐胁迫等非生物逆境的应答过程，但对于激活这些蛋白激酶的上游途径、这些蛋白激酶活性的调控、以及这些蛋白激酶下游的生物学过程仍缺乏了解。
      我们将以参与植物非生物逆境胁迫应答的蛋白激酶为研究对象，利用先进的磷酸化蛋白组学技术，在蛋白组水平鉴定参与的植物非生物胁迫应答过程的蛋白激酶的底物，构建参与非生物胁迫应答过程的蛋白激酶——底物调控网络，并解析蛋白激酶参与的下游生物学过程。针对一些重要的蛋白激酶——底物组合进行深入研究，通过遗传学、生物化学和细胞生物学研究方法解析蛋白激酶调控底物蛋白功能的分子机制。同时筛选并鉴定参与干旱、渗透、盐等非生物逆境应答的新的早期信号组分，研究植物感受和适应非生物胁迫的分子机制。

   

071001-植物学
071010-生物化学与分子生物学
071007-遗传学

蛋白激酶与植物逆境生物学

2011-09--2016-01   普渡大学   博士后
2005-09--2010-06   河南大学   理学博士
2000-09--2003-06   河南大学   理学硕士
1996-09--2000-06   河南大学   理学学士

博士

博士

   

2017-03~现在, 中国科学院上海植物逆境生物学研究中心, 研究员
2016-02~2017-02,中国科学院上海植物逆境生物学研究中心, 副研究员
2010-07~2011-09,河南大学, 副教授
2003-07~2005-08,河南大学, 助教

   

[1] Zhen Lin, Yuan Li, Yubei Wang, Xiaolei Liu, Liang Ma, Zhengjing Zhang, Chen Mu, Yan Zhang, Li Peng, Shaojun Xie, ChunPeng Song, Huazhong Shi, JianKang Zhu, Pengcheng Wang. Initiation and amplification of SnRK2 activation in abscisic acid signaling. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080645/.
[2] Zhou, Jinggeng, Wang, Xiaoyang, He, Yunxia, Sang, Tian, Wang, Pengcheng, Dai, Shaojun, Zhang, Shuqun, Meng, Xiangzong. Differential Phosphorylation of the Transcription Factor WRKY33 by the Protein Kinases CPK5/CPK6 and MPK3/MPK6 Cooperatively Regulates Camalexin Biosynthesis in Arabidopsis. PLANT CELL[J]. 2020, 32(8): 2621-2638, [3] Zhen Lin, Yuan Li, Zhengjing Zhang, Xiaolei Liu, ChuanChih Hsu, Yanyan Du, Tian Sang, Chen Zhu, Yubei Wang, Viswanathan Satheesh, Pritu Pratibha, Yang Zhao, ChunPeng Song, W Andy Tao, JianKang Zhu, Pengcheng Wang. A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants. Nature Communications[J]. 2020, 11(1): 1-10, https://doaj.org/article/06d5c1664ba0430b88a579d8e6e1176d.
[4] Hsu, ChuanChih, Tsai, ChiaFeng, Tao, W Andy, Wang, Pengcheng. Phosphoproteomic Strategy for Profiling Osmotic Stress Signaling in Arabidopsis. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000546499200013.
[5] Chen, Kong, Gao, Jinghui, Sun, Shujing, Zhang, Zhengjing, Yu, Bo, Li, Jun, Xie, Changgen, Li, Guojun, Wang, Pengcheng, Song, ChunPeng, Bressan, Ray A, Hua, Jian, Zhu, JianKang, Zhao, Yang. BONZAI Proteins Control Global Osmotic Stress Responses in Plants. CURRENT BIOLOGY[J]. 2020, 30(24): 4815-+, http://dx.doi.org/10.1016/j.cub.2020.09.016.
[6] Wang, Pengcheng, Hsu, ChuanChih, Du, Yanyan, Zhu, Peipei, Zhao, Chunzhao, Fu, Xing, Zhang, Chunguang, Paez, Juan Sebastian, Macho, Alberto P, Tao, W Andy, Zhu, JianKang. Mapping proteome-wide targets of protein kinases in plant stress responses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(6): 3270-3280, https://www.webofscience.com/wos/woscc/full-record/WOS:000513898000071.
[7] He, Yuqing, Hong, Gaojie, Zhang, Hehong, Tan, Xiaoxiang, Li, Lulu, Kong, Yaze, Sang, Tian, Xie, Kaili, Wei, Jia, Li, Junmin, Yan, Fei, Wang, Pengcheng, Tong, Hongning, Chu, Chengcai, Chen, Jianping, Sun, Zongtao. The OsGSK2 Kinase Integrates Brassinosteroid and Jasmonic Acid Signaling by Interacting with OsJAZ4. PLANT CELL[J]. 2020, 32(9): 2806-2822, https://www.webofscience.com/wos/woscc/full-record/WOS:000578504100019.
[8] Wang Pengcheng. Target of Rapamycin Signaling in Plant Stress Responses.. Plant Physiol.. 2019, [9] Hongliang Wang, Siyi Guo, Xin Qiao, Jianfei Guo, Zuliang Li, Yusen Zhou, Shenglong Bai, Zhiyong Gao, Daojie Wang, Pengcheng Wang, David W Galbraith, ChunPeng Song. BZU2/ZmMUTE controls symmetrical division of guard mother cell and specifies neighbor cell fate in maize. PLOS GENETICS[J]. 2019, 15(8): https://doaj.org/article/29c511d474c04af9a7925829c8b0bccb.
[10] Wang, Pengcheng, Zhao, Yang, Li, Zhongpeng, Hsu, ChuanChih, Liu, Xue, Fu, Liwen, Hou, YuehJu, Du, Yanyan, Xie, Shaojun, Zhang, Chunguang, Gao, Jinghui, Cao, Minjie, Huang, Xiaosan, Zhu, Yingfang, Tang, Kai, Wang, Xingang, Tao, W Andy, Xiong, Yan, Zhu, JianKang. Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response. MOLECULAR CELL[J]. 2018, 69(1): 100-+, http://dx.doi.org/10.1016/j.molcel.2017.12.002.
[11] Zhao, Yang, Zhang, Zhengjing, Gao, Jinghui, Wang, Pengcheng, Hu, Tao, Wang, Zegang, Hou, YuehJu, Wan, Yizhen, Liu, Wenshan, Xie, Shaojun, Lu, Tianjiao, Xue, Liang, Liu, Yajie, Macho, Alberto P, Tao, W Andy, Bressan, Ray A, Zhu, JianKang. Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA-Independent SnRK2 Activity. CELL REPORTS[J]. 2018, 23(11): 3340-+, http://dx.doi.org/10.1016/j.celrep.2018.05.044.
[12] Yan, Jun, Wang, Pengcheng, Wang, Bangshing, Hsu, ChuanChih, Tang, Kai, Zhang, Hairong, Hou, YuehJu, Zhao, Yang, Wang, Qiming, Zhao, Chunzhao, Zhu, Xiaohong, Tao, W Andy, Li, Jianming, Zhu, JianKang. The SnRK2 kinases modulate miRNA accumulation in Arabidopsis. PLOS GENETICS[J]. 2017, 13(4): https://doaj.org/article/bc97ada7e82e40fd88a9c250b39109cb.
[13] Hou, YuehJu, Zhu, Yingfang, Wang, Pengcheng, Zhao, Yang, Xie, Shaojun, Batelli, Giorgia, Wang, Bangshing, Duan, ChengGuo, Wang, Xingang, Xing, Lu, Lei, Mingguang, Yan, Jun, Zhu, Xiaohong, Zhu, JianKang. Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling. PLOS GENETICS[J]. 2016, 12(3): https://doaj.org/article/f0e76491f921422a8a2d5d805633e270.
[14] Zhang, Ying, Wang, Pengcheng, Shao, Wanchen, Zhu, JianKang, Dong, Juan. The BASL Polarity Protein Controls a MAPK Signaling Feedback Loop in Asymmetric Cell Division. DEVELOPMENTAL CELL[J]. 2015, 33(2): 136-149, https://www.webofscience.com/wos/woscc/full-record/WOS:000353352300005.
[15] Wang Pengcheng Du Yanyan Hou YuehJu Zhao Yang Hsu ChuanChih Yuan Feijuan Zhu Xiaohong Tao W Andy Song ChunPeng Zhu JianKang. Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. 2015, 112(2): 613-618, [16] Wang, Pengcheng, Xue, Liang, Batelli, Giorgia, Lee, Shinyoung, Hou, YuehJu, Van Oosten, Michael J, Zhang, Huiming, Tao, W Andy, Zhu, JianKang. Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(27): 11205-11210, https://www.webofscience.com/wos/woscc/full-record/WOS:000321978000075.

1. 国家自然科学基金面上项目，31171363，拟南芥MAPK和硝酸还原酶介导NO产生的分
子机制，2012/01-2015/12，50万元，主持。
2. 国家自然科学基金重大研究计划，91017001，拟南芥ABA应答的MAPK级联途径的系
统解析，2011/01-2014/12，60万元，主持。
3. 国家自然科学基金青年基金，30600344，拟南芥新的过氧化氢顺式元件及其结合蛋
白的鉴定和功能分析，2007/01-2009/12，24万元，主持。

4.  国家自然科学基金面上项目，31771358，参与ABA和渗透胁迫应答的mRNA降解途径研究，2018/01-2021/12，60万元，主持。

现指导学生

桑田  硕士研究生  071007-遗传学