神经系统疾病是一类发病率较高的疾病，中风、癫痫、早老性痴呆等常见的神经系统疾病影响全球数千万人的健康，加上一些较为罕见的疾病如雷特综合征、Rasmussen脑炎等，已经成为日益严重的医疗负担和社会问题。虽然目前已有一些手段及方法应用于某些神经系统疾病的临床诊断和治疗，但基于发病机制研究的、用于预防或治愈这类神经系统疾病的方案依旧匮乏。本研究组的长期研究方向是了解这些神经系统疾病在细胞和分子水平的发病机理，其中特别关注儿童智力发育障碍疾病和癫痫病的研究。

   

071006-神经生物学

疾病神经生物学

1995-08--2000-01   美国贝勒医学院   药理学和神经科学专业，博士
1992-09--1995-07   中国科学院上海药物所   神经药理学专业，硕士
1987-09--1992-06   华西医科大学   药学专业，学士

   

2015-04~现在, 中国科学院大学, 岗位教授
2014-09~现在, 中国科学院脑科学与智能技术卓越创新中心, 脑疾病部主任
2014-03~现在, 上海科技大学, 特聘教授
2012-05~现在, 中国科学院神经科学研究所, 高级研究员，博士生导师
2003-08~2012-04,中国科学院神经科学研究所, 研究员、博士生导师
2000-03~2003-07,美国杜克大学医学中心James McNamara实验室, 博士后

2016-06-01-今,中国神经科学学会青年组会主任,
2016-06-01-今,中国神经科学学会神经病学基础与临床分会 副主任委员,
2015-10-01-今,中国神经科学学会常务理事,
2015-02-01-今,《Neurogenesis》编委,
2013-07-01-今,《Developmental Neurobiology》编委,
2012-03-01-今,《中国细胞生物学学报》编委,

神经生物学

   

（1） 赛诺菲中国神经科学优秀学者奖, 特等奖, 其他, 2014
（2） 国家百千万人才工程， “有突出贡献中青年专家”, 特等奖, 国家级, 2013
（3） 张香桐基金会青年神经科学家奖, 特等奖, 其他, 2013
（4） 中科院优秀博士论文奖导师奖, 特等奖, 院级, 2013
（5） 国务院特殊津贴, 特等奖, 国家级, 2012
（6） 上海市优秀学术带头人, 特等奖, 市地级, 2012
（7） 国家杰出青年科学基金, 特等奖, 国家级, 2009
（8） 中科院上海分院杰出青年科技创新人才奖, 特等奖, 院级, 2008
（9） 上海市“浦江人才计划”, 特等奖, 市地级, 2006
（10） 中科院“****”, 特等奖, 院级, 2003

[1] 孙强, 刘真, 熊志奇, 李奎. 一种性早熟动物模型的构建方法及其应用. CN: CN113615638A, 2021-11-09.
[2] 孙强, 陆宗阳, 刘真, 熊志奇, 姜建. STXBP1突变动物模型的构建及其应用. CN: CN113528584A, 2021-10-22.
[3] 熊志奇, 孙强, 翟荣伟, 王振. 制备具有强迫仪式样行为的非人灵长类动物模型的方法. CN: CN110810323B, 2021-09-14.
[4] 王柠, 陈万金, 程学文, 熊志奇, 姚香平. 第103位点发生突变的人类PFBC致病基因MYORG及其应用. CN: CN112342206A, 2021-02-09.
[5] 熊志奇, 朱志川, 李奎. KPNB1抑制剂和Bcl-xL抑制剂在制备抗肿瘤药物中的应用. CN: CN109718377A, 2019-05-07.
[6] 熊志奇, 朱志川, 李奎. KPNB1抑制剂和蛋白降解途径抑制剂在制备抗肿瘤药物中的应用. CN: CN109718378A, 2019-05-07.
[7] 陈万金, 王柠, 熊志奇, 姚香平, 程学文, 王冲, 赵淼. 原发性家族性脑钙化症致病基因MYORG及其应用. CN: CN108715838A, 2018-10-30.
[8] 熊志奇, 朱志川, 李奎. 一种治疗肿瘤的联合用药方法. CN: CN108619488A, 2018-10-09.

   

[1] Jiang, Mengying, Xu, Qiwu, Yang, Can, Li, Dan, Liu, JiWei, Zhang, Yuxian, Zhu, YongChuan, Xiong, ZhiQi. Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity. NEUROSCIENCE BULLETIN[J]. 2023, 39(9): http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7546608&detailType=1.
[2] Xu, RuoShui, Wu, XueMei, Xiong, ZhiQi. Low-intensity ultrasound directly modulates neural activity of the cerebellar cortex. BRAIN STIMULATION[J]. 2023, 16(3): 918-926, http://dx.doi.org/10.1016/j.brs.2023.05.012.
[3] ZiAi Zhu, YiYan Li, Juan Xu, Hui Xue, Xue Feng, YongChuan Zhu, ZhiQi Xiong. CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling. CELL REPORTS[J]. 2023, 42(10): 113202-, https://doaj.org/article/a7da276a6a804eaf86cd6798b566f76e.
[4] Zhao, M., Su, H., Zeng, Y, Sun, Y., Guo, X., Li, Y., Wang, C, Zhao, Z., Huang, X., Lin, K., Ye, Z., Lin, B., Hong, S., Zheng, J., Liu, Y., Yao, X., Yang, D., Lu, Y., Chen, H., Zuo, E., Yang, G., Wang, H., Huang, C., Lin, X., Cen, Z., Lai, L., Zhang, Y., Li, X., Lai, T., Lin, L., Zuo, D., Lin, M., Liou, C., Kong, Q., Yan, C., xiong zhiqi, Wang, N., Luo, W., Zhao, C., Cheng, X., Chen, W.. Loss of function of CMPK2 causes mitochondria deficiency and brain calcification.. Cell Discovery[J]. 2022, 8: 128-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705363/pdf/41421_2022_Article_475.pdf.
[5] Lu, Bin, Lou, SenSen, Xu, RuoShui, Kong, DeLun, Wu, RongJie, Zhang, Jing, Zhuang, Ling, Wu, XueMei, He, JunYan, Wu, ZhiYing, Xiong, ZhiQi. Cerebellar spreading depolarization mediates paroxysmal movement disorder. CELL REPORTS[J]. 2021, 36(12): http://dx.doi.org/10.1016/j.celrep.2021.109743.
[6] Wang, HongTao, Zhu, ZiAi, Li, YiYan, Lou, SenSen, Yang, Guang, Feng, Xue, Xu, Wei, Huang, ZhiLi, Cheng, Xuewen, Xiong, ZhiQi. CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures. EPILEPSIA[J]. 2021, 62(2): 517-528, http://dx.doi.org/10.1111/epi.16805.
[7] Wang, Fei, Wang, Qianqian, Liu, Baowei, Mei, Lisheng, Ma, Sisi, Wang, Shujuan, Wang, Ruoyu, Zhang, Yan, Niu, Chaoshi, Xiong, Zhiqi, Zheng, Yong, Zhang, Zhi, Shi, Juan, Song, Xiaoyuan. The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. CELL DEATH AND DIFFERENTIATION[J]. 2021, 28(9): 2634-2650, http://dx.doi.org/10.1038/s41418-021-00774-3.
[8] Liu, Zhen, Li, Kui, Cai, Yijun, Liu, Qiming, Zhang, Tikui, Lu, Yong, Nie, Yanhong, Wang, Yan, Yan, Zhiguang, Qu, Yinwei, Li, Yuzhuo, Wang, Zhanyang, Xiong, ZhiQi, Sun, Qiang. Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty. NATIONAL SCIENCE REVIEW[J]. 2021, 8(7): 63-66, http://dx.doi.org/10.1093/nsr/nwab083.
[9] Xiong Zhiqi. TMEM151A variants cause paroxysmal kinesigenic dyskinesias. Cell Discovery. 2021, [10] Qin, XinYa, Shan, QingHong, Fang, Hui, Wang, Yu, Chen, Peng, Xiong, ZhiQi, Swaab, Dick F, Zhou, JiangNing. PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression. ACTA NEUROPATHOLOGICA[J]. 2021, 142(6): 1045-1064, http://dx.doi.org/10.1007/s00401-021-02371-7.
[11] WanJin Chen, Xuewen Cheng, Ying Fu, Miao Zhao, Jennifer McGinley, Ana Westenberger, ZhiQi Xiong. Rethinking monogenic neurological diseases. THE BMJ. 2020, 371: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542538/.
[12] Chen, WanJin, Cheng, Xuewen, Fu, Ying, Zhao, Miao, McGinley, Jennifer, Westenberger, Ana, Xiong, ZhiQi. Rethinking monogenic neurological diseases. BMJ-BRITISH MEDICAL JOURNAL[J]. 2020, 371: http://dx.doi.org/10.1136/bmj.m3752.
[13] Liu, Jianan, Pan, Limin, Shang, Chunfeng, Lu, Bin, Wu, Rongjie, Feng, Yun, Chen, Weiyu, Zhang, Rongwei, Bu, Jiwen, Xiong, Zhiqi, Bu, Wenbo, Du, Jiulin, Shi, Jianlin. A highly sensitive and selective nanosensor for near-infrared potassium imaging. SCIENCEADVANCES[J]. 2020, 6(16): https://www.webofscience.com/wos/woscc/full-record/WOS:000528276800006.
[14] Wang, Tingting, Wang, Jingyu, Wang, Jie, Mao, Lin, Tang, Bin, Vanderklish, Peter W, Liao, Xun, Xiong, ZhiQi, Liao, Lujian. HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome. NEUROBIOLOGY OF DISEASE[J]. 2019, 132: http://dx.doi.org/10.1016/j.nbd.2019.104585.
[15] Lin, Xiang, Su, HuiZhen, Dong, EnLin, Lin, XiaoHong, Zhao, Miao, Yang, Can, Wang, Chong, Wang, Jie, Chen, YiJun, Yu, Hongjie, Xu, Jianfeng, Ma, LiXiang, Xiong, ZhiQi, Wang, Ning, Chen, WanJin. Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia. BRAIN[J]. 2019, 142: 2238-2252, http://dx.doi.org/10.1093/brain/awz158.
[16] Zhu, ZhiChuan, Liu, JiWei, Yang, Can, Li, MingJie, Wu, RongJie, Xiong, ZhiQi. Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. CELL DEATH & DISEASE[J]. 2019, 10(2): https://doaj.org/article/b3f1ac402efa455b8edd389c4f5c56d8.
[17] Zhu, ZhiChuan, Liu, JiWei, Yang, Can, Zhao, Miao, Xiong, ZhiQi. XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. CELL DEATH & DISEASE[J]. 2019, 10(6): http://dx.doi.org/10.1038/s41419-019-1627-9.
[18] Wang, Jie, Lou, SenSen, Wang, Tingting, Wu, RongJie, Li, Guangying, Zhao, Miao, Lu, Bin, Li, YiYan, Zhang, Jing, Cheng, Xuewen, Shen, Ya, Wang, Xing, Zhu, ZhiChuan, Li, MingJie, Takumi, Toru, Yang, Hui, Yu, Xiang, Liao, Lujian, Xiong, ZhiQi. UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(25): 12500-12505, http://dx.doi.org/10.1073/pnas.1820131116.
[19] Zhu, ZhiChuan, Liu, JiWei, Li, Kui, Zheng, Jing, Xiong, ZhiQi. KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells. ONCOGENE[J]. 2018, 37(22): 2936-2952, http://dx.doi.org/10.1038/s41388-018-0180-9.
[20] Xu, Qiong, Liu, Yuanyuan, Wang, Xiaoming, Tan, Guohe, Li, Huiping, Hulbert, Samuel W, Li, Chunyang, Hu, Chunchun, Xiong, Zhiqi, Xu, Xiu, Jiang, Yonghui. Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons. MOLECULAR AUTISM[J]. 2018, 9(1): https://doaj.org/article/f5e82f90f69d4bb7af33c882d69be995.
[21] Xu, Xingxing, Li, Chuanyin, Gao, Xiaobo, Xia, Kun, Guo, Hui, Li, Yali, Hao, Zijian, Zhang, Lei, Gao, Daming, Xu, Chenfan, Xu, Huatai, Xiong, ZhiQi, Qiu, Zilong, Mei, Ling, Xie, Xiaoduo, Ruan, Kangcheng, Hu, Ronggui. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. CELL RESEARCH[J]. 2018, 28(1): 48-68, http://202.127.25.143/handle/331003/3402.
[22] Tan, GuoHe, Liu, YuanYuan, Wang, Lu, Li, Kui, Zhang, ZeQiang, Li, HongFu, Yang, ZhongFei, Li, Yang, Li, Dan, Wu, MingYue, Yu, ChunLei, Long, JuanJuan, Chen, RenChao, Li, LiXi, Yin, LuPing, Liu, JiWei, Cheng, XueWen, Shen, Qi, Shu, YouSheng, Sakimura, Kenji, Liao, LuJian, Wu, ZhiYing, Xiong, ZhiQi. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. CELL RESEARCH[J]. 2018, 28(1): 90-110, http://dx.doi.org/10.1038/cr.2017.128.
[23] Yao, XiangPing, Cheng, Xuewen, Wang, Chong, Zhao, Miao, Guo, XinXin, Su, HuiZhen, Lai, LuLu, Zou, XiaoHuan, Chen, XueJiao, Zhao, Yuying, Dong, EnLin, Lu, YingQian, Wu, Shuang, Li, Xiaojuan, Fan, Gaofeng, Yu, Hongjie, Xu, Jianfeng, Wang, Ning, Xiong, ZhiQi, Chen, WanJin. Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. NEURON[J]. 2018, 98(6): 1116-+, http://dx.doi.org/10.1016/j.neuron.2018.05.037.
[24] Yang, Zhi, Li, PengFei, Chen, RenChao, Wang, Jie, Wang, Shaoran, Shen, Ya, Wu, Xiaohui, Fang, Bing, Cheng, Xuewen, Xiong, ZhiQi. ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons. CEREBRAL CORTEX[J]. 2017, 27(2): 919-932, http://dx.doi.org/10.1093/cercor/bhx006.
[25] Zuo, Erwei, Cai, YiJun, Li, Kui, Wei, Yu, Wang, BangAn, Sun, Yidi, Liu, Zhen, Liu, Jiwei, Hu, Xinde, Wei, Wei, Huo, Xiaona, Shi, Linyu, Tang, Cheng, Liang, Dan, Wang, Yan, Nie, YanHong, Zhang, ChenChen, Yao, Xuan, Wang, Xing, Zhou, Changyang, Ying, Wenqin, Wang, Qifang, Chen, RenChao, Shen, Qi, Xu, GuoLiang, Li, Jinsong, Sun, Qiang, Xiong, ZhiQi, Yang, Hui. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. CELL RESEARCH[J]. 2017, 27(7): 933-945, http://www.corc.org.cn/handle/1471x/2188612.
[26] Poo, Muming, Du, Jiulin, Ip, Nancy Y, Xiong, ZhiQi, Xu, Bo, Tan, Tieniu. China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing. NEURON. 2016, 92(3): 591-596, http://dx.doi.org/10.1016/j.neuron.2016.10.050.
[27] Liu, Zhen, Li, Xiao, Zhang, JunTao, Cai, YiJun, Cheng, TianLin, Cheng, Cheng, Wang, Yan, Zhang, ChenChen, Nie, YanHong, Chen, ZhiFang, Bian, WenJie, Zhang, Ling, Xiao, Jianqiu, Lu, Bin, Zhang, YueFang, Zhang, XiaoDi, Sang, Xiao, Wu, JiaJia, Xu, Xiu, Xiong, ZhiQi, Zhang, Feng, Yu, Xiang, Gong, Neng, Zhou, WenHao, Sun, Qiang, Qiu, Zilong. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. NATURE[J]. 2016, 530(7588): 98-+, http://dx.doi.org/10.1038/nature16533.
[28] Xiong, Hui, Casse, Frederic, Zhou, Ming, Xiong, ZhiQi, Joels, Marian, Martin, Stephane, Krugers, Harm J. Interactions Between N-Ethylmaleimide- Sensitive Factor and GluA2 Contribute to Effects of Glucocorticoid Hormones on AMPA Receptor Function in the Rodent Hippocampus. HIPPOCAMPUS[J]. 2016, 26(7): 848-856, https://www.webofscience.com/wos/woscc/full-record/WOS:000383272600003.
[29] Li, Yang, Wang, Jie, Zhou, Yang, Li, Dan, Xiong, ZhiQi. Rcan1 Deficiency Impairs Neuronal Migration and Causes Periventricular Heterotopia. JOURNAL OF NEUROSCIENCE[J]. 2015, 35(2): 610-620, http://ir.sibs.ac.cn/handle/331001/2668.
[30] Miao, Sheng, Chen, Renchao, Ye, Jiahao, Tan, GuoHe, Li, Shuai, Zhang, Jing, Jiang, Yonghui, Xiong, ZhiQi. The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons. JOURNAL OF NEUROSCIENCE[J]. 2013, 33(1): 327-333, http://www.irgrid.ac.cn/handle/1471x/647571.
[31] Li, HongFu, Ni, Wang, Xiong, ZhiQi, Xu, Jianfeng, Wu, ZhiYing. PRRT2 c.649dupC Mutation Derived from De Novo in Paroxysmal Kinesigenic Dyskinesia. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2013, 19(1): 61-65, http://www.irgrid.ac.cn/handle/1471x/647567.
[32] Lu, Tingjia, Chen, Renchao, Cox, Timothy C, Moldrich, Randal X, Kurniawan, Nyoman, Tan, Guohe, Perry, Jo K, Ashworth, Alan, Bartlett, Perry F, Xu, Li, Zhang, Jing, Lu, Bin, Wu, Mingyue, Shen, Qi, Liu, Yuanyuan, Richards, Linda J, Xiong, Zhiqi. X-linked microtubule-associated protein, Mid1, regulates axon development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(47): 19131-19136, http://dx.doi.org/10.1073/pnas.1303687110.
[33] Zhu, YongChuan, Li, Dan, Wang, Lu, Lu, Bin, Zheng, Jing, Zhao, ShiLin, Zeng, Rong, Xiong, ZhiQi. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 110(22): 9118-9123, http://www.irgrid.ac.cn/handle/1471x/735010.
[34] Guo, ShunLing, Tan, GuoHe, Li, Shuai, Cheng, XueWen, Zhou, Ya, Jia, YunFang, Xiong, Hui, Tao, Jiong, Xiong, ZhiQi. Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization. CELL RESEARCH[J]. 2012, 22(2): 387-398, http://lib.cqvip.com/Qikan/Article/Detail?id=42510480.
[35] Tan, GuoHe, Liu, YuanYuan, Hu, XiaoLing, Yin, DongMin, Mei, Lin, Xiong, ZhiQi. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. NATURE NEUROSCIENCE[J]. 2012, 15(2): 258-266, http://www.irgrid.ac.cn/handle/1471x/502192.
[36] Hu, XiaoLing, Cheng, Xuewen, Fei, Jian, Xiong, ZhiQi. Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet. EPILEPSIA[J]. 2011, 52(9): 1609-1616, http://www.irgrid.ac.cn/handle/1471x/502194.
[37] Xiong Zhiqi. Exome sequencing identifies truncating mutations in PRRT2 that casue paroxysmal kinesigenic dyskinesia. Nature Genetics. 2011, [38] Cheng, Xuewen, Li, Yang, Huang, Ying, Feng, Xiaoyan, Feng, Guoping, Xiong, ZhiQi. Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone. CELL RESEARCH[J]. 2011, 21(2): 338-349, http://www.irgrid.ac.cn/handle/1471x/502196.
[39] Hu, XiaoLing, Cheng, Xuewen, Cai, Lei, Tan, GuoHe, Xu, Li, Feng, XiaoYan, Lu, TingJia, Xiong, Hui, Fei, Jian, Xiong, ZhiQi. Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model. CEREBRAL CORTEX[J]. 2011, 21(9): 2158-2165, http://www.irgrid.ac.cn/handle/1471x/502195.
[40] Chen, Qian, Zhu, YongChuan, Yu, Jing, Miao, Sheng, Zheng, Jing, Xu, Li, Zhou, Yang, Li, Dan, Zhang, Chi, Tao, Jiong, Xiong, ZhiQi. CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling. JOURNAL OF NEUROSCIENCE[J]. 2010, 30(38): 12777-12786, http://www.irgrid.ac.cn/handle/1471x/502197.
[41] Qiu, LiFeng, Lu, TingJia, Hu, XiaoLing, Yi, YongHong, Liao, WeiPing, Xiong, ZhiQi. Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome. CEREBRAL CORTEX[J]. 2009, 19(7): 1504-1514, http://dx.doi.org/10.1093/cercor/bhn163.
[42] Zhou, Yang, Lu, TingJia, Xiong, ZhiQi. NGF-dependent retrograde signaling: survival versus death. CELL RESEARCH[J]. 2009, 19(5): 525-526, http://lib.cqvip.com/Qikan/Article/Detail?id=30274310.
[43] Chen, Min, Chen, Qian, Cheng, XueWen, Lu, TingJia, Liu, HanXing, Jia, JieMin, Zhang, Chi, Xu, Li, Xiong, ZhiQi. Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus. JOURNAL OF NEUROCHEMISTRY[J]. 2009, 111(5): 1094-1103, http://www.irgrid.ac.cn/handle/1471x/502198.
[44] Huang, Yang Z, Pan, Enhui, Xiong, ZhiQi, McNamara, James O. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy Fiber-CA3 pyramid synapse. NEURON[J]. 2008, 57(4): 546-558, http://dx.doi.org/10.1016/j.neuron.2007.11.026.
[45] Chen, Min, Lu, TingJia, Chen, XiaoJing, Zhou, Yang, Chen, Qian, Feng, XiaoYan, Xu, Li, Duan, WenHu, Xiong, ZhiQi. Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance. STROKE[J]. 2008, 39(11): 3042-3048, http://ir.simm.ac.cn/handle/153631/1347.
[46] Zheng, Jing, Shen, WanHua, Lu, TingJia, Zhou, Yang, Chen, Qian, Wang, Zi, Xiang, Ting, Zhu, YongChuan, Zhang, Chi, Duan, Shumin, Xiong, ZhiQi. Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(19): 13280-13288, http://dx.doi.org/10.1074/jbc.M709930200.
[47] LiFeng Qiu, YanHong Hao, QingZhang Li, ZhiQi Xiong. Fragile X syndrome and epilepsy. NEUROSCIENCE BULLETIN. 2008, 24(5): 338-344, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552528/.
[48] Chen, Qian, He, Songtao, Hu, XiaoLing, Yu, Jing, Zhou, Yang, Zheng, Jing, Zhang, Shilei, Zhang, Chi, Duan, WenHu, Xiong, ZhiQi. Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. JOURNAL OF NEUROSCIENCE[J]. 2007, 27(3): 542-552, http://www.irgrid.ac.cn/handle/1471x/502209.
[49] Wu, Hao, Zhou, Yang, Xiong, ZhiQi. Transducer of regulated CREB and late phase long-term synaptic potentiation. FEBS JOURNAL[J]. 2007, 274(13): 3218-3223, http://www.irgrid.ac.cn/handle/1471x/502208.
[50] Zhou, Yang, Wu, Hao, Li, Shuai, Chen, Qian, Cheng, XueWen, Zheng, Jing, Takemori, Hiroshi, Xiong, ZhiQi. Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus. PLOS ONE[J]. 2006, 1(1): http://www.irgrid.ac.cn/handle/1471x/502210.
[51] Xiong, ZQ, Qian, WH, Suzuki, K, McNamara, JO. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. JOURNAL OF NEUROSCIENCE[J]. 2003, 23(3): 955-960, https://www.webofscience.com/wos/woscc/full-record/WOS:000180865400026.
[52] Xiong, ZQ, McNamara, JO. Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. NEURON[J]. 2002, 36(3): 363-374, http://dx.doi.org/10.1016/S0896-6273(02)00977-7.
[53] Xiong, ZQ, McNamara, JO. Fas(t) balls and Lou Gehrig disease: A clue to selective vulnerability of motor neurons?. NEURONnull. 2002, 35(6): 1011-1013, http://dx.doi.org/10.1016/S0896-6273(02)00910-8.
[54] Zhi-Qi Xiong, Janet L Stringer. Effects of postsynaptic GABA B receptor activation on epileptiform activity in hippocampal slices. NEUROPHARMACOLOGY. 2001, 40(1): 131-138, http://dx.doi.org/10.1016/S0028-3908(00)00120-9.
[55] Xiong, ZQ, Stringer, JL. Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission. JOURNAL OF NEUROPHYSIOLOGY[J]. 2001, 86(5): 2625-2628, https://www.webofscience.com/wos/woscc/full-record/WOS:000172012800045.
[56] Schweitzer, JS, Wang, HW, Xiong, ZQ, Stringer, JL. pH sensitivity of non-synaptic field bursts in the dentate gyrus. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 84(2): 927-933, https://www.webofscience.com/wos/woscc/full-record/WOS:000088684700029.
[57] Xiong, ZQ, Stringer, JL. Regulation of extracellular pH in the developing hippocampus. DEVELOPMENTAL BRAIN RESEARCH[J]. 2000, 122(2): 113-117, http://dx.doi.org/10.1016/S0165-3806(00)00057-2.
[58] Xiong, ZQ, Saggau, P, Stringer, JL. Activity-dependent intracellular acidification correlates with the duration of seizure activity. JOURNAL OF NEUROSCIENCE[J]. 2000, 20(4): 1290-1296, https://www.webofscience.com/wos/woscc/full-record/WOS:000085181200002.
[59] Xiong, ZQ, Stringer, FL. Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 83(3): 1443-1451, https://www.webofscience.com/wos/woscc/full-record/WOS:000085951200030.
[60] Xiong, ZQ, Stringer, JL. Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 83(6): 3519-3524, https://www.webofscience.com/wos/woscc/full-record/WOS:000087574000028.
[61] Xiong, ZQ, Stringer, JL. Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus. JOURNAL OF NEUROPHYSIOLOGY[J]. 1999, 82(6): 3339-3346, https://www.webofscience.com/wos/woscc/full-record/WOS:000084422100043.
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[63] Xiong, ZQ, Cheng, DH, Tang, XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. ACTA PHARMACOLOGICA SINICA[J]. 1998, 19(2): 128-132, https://www.webofscience.com/wos/woscc/full-record/WOS:000072465400008.
[64] Xiong, ZQ, Stringer, JL. Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. EPILEPSY RESEARCH[J]. 1997, 27(3): 187-194, http://dx.doi.org/10.1016/S0920-1211(97)00022-3.
[65] Xiong Zhiqi. Effect of –N omega-nitro-L-arginie on working memory of rats in eight-arm maze task. Acta Pharmacologica Sinica. 1995, [66] XIONG, ZQ, TANG, XC. EFFECT OF HUPERZINE-A, A NOVEL ACETYLCHOLINESTERASE INHIBITOR, ON RADIAL MAZE PERFORMANCE IN RATS. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 1995, 51(2-3): 415-419, http://www.corc.org.cn/handle/1471x/2373279.
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[69] Yang Zhi, Li Peng-Fei, Chen Ren-Chao, Wang Jie, Wang Shaoran, Shen Ya, Wu Xiaohui, Fang Bing, Cheng Xuewen, Xiong Zhi-Qi. ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons. CEREBRAL CORTEX (NEW YORK, NY). 27(2): 919-932, https://www.webofscience.com/wos/woscc/full-record/WOS:000397257600004.
[70] Jia Jie-Min, Chen Qian, Zhou Yang, Miao Sheng, Zheng Jing, Zhang Chi, Xiong Zhi-Qi. Brain-derived Neurotrophic Factor-Tropomyosin-related Kinase B Signaling Contributes to Activity-dependent Changes in Synaptic Proteins *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 283(30): 21242-21250, http://dx.doi.org/10.1074/jbc.M800282200.

   

（ 1 ） 雷特综合症认知功能障碍的分子和神经环路基础, 主持, 国家级, 2014-01--2017-12
（ 2 ） 突触构造的发育与可塑性, 主持, 部委级, 2015-01--2017-07
（ 3 ） 神经元形态发生和功能成熟的分子细胞机制, 参与, 国家级, 2015-01--2019-12
（ 4 ） 大脑皮层和单胺类神经元发育的分子调控网络三期－熊志奇, 参与, 国家级, 2014-01--2016-12
（ 5 ） 囊泡蛋白质机器在神经发育中的作用, 参与, 国家级, 2016-07--2021-06
（ 6 ） 发作性运动障碍分子和环路机制研究, 主持, 部委级, 2016-09--2021-09

（1）Molecular mechanism of intellectual disability   2015-11-07
（2）Synaptic and circuit basis of PKD   2015-09-21
（3）Palmitoylation-dependent CDKL5–PSD95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development   2014-11-15
（4）Synaptic function of CDKL5   2014-06-23
（5）Reelin regulates intramembrane proteolysis signaling to control radial migration of cortical neuron.   2014-05-12
（6）Prrt2-deficiency Impairs Presynaptic Plasticity and Voluntary Movements   2014-04-25

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