基本信息
刘思金  男  博导  中国科学院生态环境研究中心
电子邮件: sjliu@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码: 100085

研究领域

环境医学与环境毒理学,主要内容包括:(1)环境污染物对血细胞损伤的分子机制;(2)环境肿瘤学及肿瘤进展的机理;(3)人工纳米材料的生物安全性。

招生信息

   
招生专业
083001-环境科学
070321-化学生物学
招生方向
环境肿瘤学,纳米生物学
环境毒理学,纳米生物学

教育背景

2001-09--2004-07   中科院遗传发育所   博士
学历
   
学位
   

工作经历

   
工作简历
2008-02~2009-08,美国塔芙茨大学医学院, 讲师
2007-07~2008-01,美国哈佛大学医学院, 研究助理
2004-08~2007-06,美国麻省理工学院, 博士后
社会兼职
2012-02-27-今,国家环境与健康专家咨询委员会, 委员

教授课程

现代生物学技术在环境健康研究中的应用
环境污染与健康危害进展

专利与奖励

   
奖励信息
(1) 十四届中国青年科技奖, 国家级, 2016
(2) 美国骨与矿物质学会青年研究者奖, 一等奖, 其他, 2009
专利成果
   

出版信息

   
发表论文
(1) miR-214protectserythroidcellsagainstoxidativestressbytargeting ATF4andEZH2, FreeRadicalBiologyandMedicine, 2016, 通讯作者
(2) Hepcidin: A Promising Therapeutic Target for Iron Disorders, Medicine, 2016, 通讯作者
(3) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)- Functionalization is Superior to PEGylation, ACS Nano, 2016, 通讯作者
(4) Bisphenol A and Hormone-Associated Cancers: Current Progress and Perspectives, Medicine, 2015, 通讯作者
(5) CrucialRole of Lateral Size forGraphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals, ACS Nano, 2015, 通讯作者
(6) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status, Biomaterials, 2015, 通讯作者
(7) Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, ScienceDirect, 2015, 通讯作者
(8) An important role of the hepcidin–ferroportin signaling in affecting tumor growth and metastasis, Original Article, 2015, 通讯作者
(9) Establishment of a novel orthotopic model of breast cancer metastasis to the lung, ONCOLOGY REPORTS, 2015, 通讯作者
(10) Mechanisms of nanosilver-induced toxicological effects: more attention should be paid to its sublethal effects, Nanoscale, 2015, 通讯作者
(11) Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis, MOLECULAR MEDICINE, 2015, 通讯作者
(12) Polychlorinated Biphenyls (PCBs) Inhibit Hepcidin Expression through an Estrogen-Like Effect Associated with Disordered Systemic Iron Homeostasis, chemistry research in toxicology, 2015, 通讯作者
(13) Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element, Cellular Signalling, 2015, 通讯作者
(14) Disordered signaling governing ferroportin transcription favors breast cancer growth, Cellular Signalling, 2015, 通讯作者
(15) Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element, MOLECULAR MEDICINE, 2015, 通讯作者
(16) Heme-Regulated eIF2α Kinase Plays a Crucial Role in Protecting Erythroid Cells against Pb-Induced Hemolytic Stress, chemistry research in toxicology, 2015, 通讯作者
(17) Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells, ACS Nano, 2014, 通讯作者
(18) Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress, Oncogene, 2014, 通讯作者
(19) HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis, Oncogenes and Tumor Suppressors, 2014, 通讯作者
(20) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc, Oncogene, 2014, 通讯作者
(21) Disordered hepcidin–ferroportin signaling promotes breast cancer growth, Cellular Signalling, 2014, 通讯作者
(22) Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload, Gene, 2014, 通讯作者
(23) Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages, MOLECULAR MEDICINE, 2014, 通讯作者
(24) 重金属暴露与前列腺癌发生和进展的关系综述, ENVIRONMENTAL CHEMISTRY, 2014, 通讯作者
(25) Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages, Nanoscale Research Letters, 2013, 通讯作者
(26) Silver nanoparticles induced RNA polymerase-silver binding and RNA transcription inhibition in erythroid progenitor cells, ACS Nano, 2013, 通讯作者
(27) Evaluation of the biological fate and the transport through biological barriers of nanosilver in mice, Current Pharmaceutical Design, 2013, 通讯作者
(28) The capability quantum dots in crossing placental barrier and the potential influence on erythrocytes, Journal of Nanoscience and Nanotechnology, 2013, 通讯作者
(29) Characterization of the interaction between cadmium and chlorpyrifos with integrative techniques in incurring synergistic hepatoxicity, PLoS One, 2013, 通讯作者
(30) Identification of TBBPA MAE and TBBPA MBPE as emerging brominated substances in the ambient environment near a manufacturing site and in mollusks at a coastal region: byproducts or transformation products of other TBBPA derivatives, Environ Sci Technol, 2013, 通讯作者
(31) The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide’s biocompatibility, J Environ Sci, 2013, 通讯作者
(32) Quantum dots (QDs) restrain human cervical carcinoma HeLa cell proliferation through inhibition of the ROCK-c-Myc signaling, Integr Biol (Camb), 2013, 通讯作者
(33) Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling, Nanoscale, 2012, 通讯作者
(34) Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer, Oncol Rep, 2012, 通讯作者
(35) A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer, Oncology Letters, 2012, 通讯作者
(36) Carbon nanotubes provoke inflammation by inducing the pro-inflammatory genes, Gene, 2012, 通讯作者
(37) Subcellular distribution of CdSe quantum dots (QDs) in breast cancer cells., Journal of Nanoscience and Nanotechnology, 2012, 通讯作者
(38) Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element, Gene, 2012, 通讯作者
(39) A lung cancer gene GPC5 could also be crucial in breast cancer, Molecular Genetics and Metabolism, 2011, 通讯作者
(40) AG490: An inhibitor of hepcidin expression in vivo, World J Gastroenterol, 2011, 通讯作者
(41) CdSe Quantum Dot (QD)-Induced Morphological and Functional Impairments to Liver in Mice, Plos One, 2011, 通讯作者
(42) The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression, SCIENCE CHINA Chemistry, 2010, 第 1 作者
(43) Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK), Plos One, 2010, 第 1 作者
(44) Inhibition of ROCK signaling prevents breast cancer metastasis to human bone, Cancer Research, 2009, 第 1 作者
(45) Deficiency of Heme-regulated eIF2a decreases hepcidin expression and splenic iron in HFE-/- mice, Haematologica, 2008, 第 1 作者
(46) Heme-regulated eIF2α kinase is necessary for erythropoiesis in the stress of iron deficiency. British Journal of Haematology, British Journal of Haematology, 2008, 第 1 作者
(47) The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation, Journal of Clinical Investigation, 2007, 第 1 作者
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发表著作
   

科研活动

   
科研项目
( 1 ) 典型有机磷农药和重金属的联合毒性效应与作用机理, 主持, 国家级, 2011-01--2013-12
( 2 ) 持久性有机污染物的分子毒理学研究, 主持, 部委级, 2009-09--2013-12
( 3 ) 多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的影响及相关分子机制的研究, 主持, 国家级, 2011-01--2013-12
( 4 ) 纳米银的胚胎发育毒性机理研究, 主持, 国家级, 2012-01--2015-12
( 5 ) 人工纳米材料环境效应的分子作用机制研究, 主持, 国家级, 2014-01--2018-12
( 6 ) 典型污染物对肿瘤细胞增殖与转移的影响机制, 主持, 部委级, 2014-07--2019-06
( 7 ) 环境污染物的毒理与健康效应, 主持, 国家级, 2015-01--2018-12
参与会议
   

合作情况

   
项目协作单位
   

指导学生

已指导学生

张书平  01  19367  

王雷  02  19597  

王立新  01  19367  

王哲  01  19367  

王小岩  01  19367  

郭文丽  01  19367  

马娟  01  19367  

现指导学生

高婕  02  67674  

刘静  01  19367  

张洁  01  19367  

陈禹男  02  67011  

吴亚坤  01  19367  

尹春阳  01  19132  

陈永久  01  19367  

申心铭  02  63228  

杨秋源  01  19367  

汪顺浩  01  19132