（1）蛋白质结构解析方法研究；
（2）时间分辨蛋白结构研究；
（3）X射线生物成像。

070205-凝聚态物理
071010-生物化学与分子生物学
071011-生物物理学

蛋白质结构和功能，X射线晶体学
DNA损伤修复的结构生物学研究
溶液状态蛋白质结构研究

1990-09--1995-07   中国科学院高能物理研究所   理学博士
1986-09--1990-07   中山大学物理系   理学学士

-- 研究生

-- 博士

1995.7-1997.7：中国科学院物理研究所博士后；
1997.7-2001.1：意大利Trento大学工学院，博士后，客座研究员；
2001.1至今：入选中国科学院“引进国外杰出人才”，任中国科学院高能物理研究所研究员。

2001-01~现在, 中国科学院高能物理研究所, 研究员
1997-07~2001-01,意大利Trento大学工学院, 博士后，客座研究员
1995-07~1997-07,中国科学院物理研究所, 博士后

X射线晶体学（近代物理方向）
科研实践Ⅱ-前沿物理研究******
同步辐射应用概论
科研实践Ⅰ-综合物理实验******
X射线晶体学
结构生物学导论
X射线晶体学（2）
X射线晶体学（1）
X射线晶体学(2)
X射线晶体学(1)

北京市科技进步二等奖

[1] 李明, 张冬霓, 刘鹏, 张常睿, 崔荣丽, 盛伟繁, 董宇辉, 陶冶. 一种分频拼接干涉仪. CN: CN116718103A, 2023-09-08.
[2] 李明, 张冬霓, 李啸宇, 陆辉华, 黎刚, 董宇辉, 盛伟繁, 刘鹏. 芒果扭摆器. CN: CN114501769A, 2022-05-13.
[3] 李明, 张冬霓, 李啸宇, 陆辉华, 黎刚, 董宇辉, 盛伟繁, 刘鹏. 芒果扭摆器. CN: CN114501769A, 2022-05-13.
[4] 李明, 张冬霓, 李啸宇, 陆辉华, 黎刚, 董宇辉, 盛伟繁, 刘鹏. 芒果扭摆器. CN: CN114501769A, 2022-05-13.
[5] 王文佳, 常广才, 胡凌飞, 张连辉, 董宇辉, 刘鹏. 去除X射线散射和衍射实验中模糊效应的方法. CN: CN104268421B, 2017-07-28.
[6] 王文佳, 常广才, 胡凌飞, 张连辉, 董宇辉, 刘鹏. 去除X射线散射和衍射实验中模糊效应的方法. CN: CN104268421A, 2015-01-07.

   

[1] Minghui Sun, Zheng Dong, Liyuan Wu, Haodong Yao, Wenchao Niu, Deting Xu, Ping Chen, Himadri Shikhar Gupta, Yi Zhang, Yuhui Dong, Chunying Chen, Lina Zhao. Fast extraction of three-dimensional nanofiber orientation from WAXD patterns using machine learning. IUCrJ[J]. 2023, 10(3): https://journals.iucr.org/m/issues/2023/03/00/ro5032/.
[2] Zhongzheng Zhou, Chun Li, Xiaoxue Bi, Chenglong Zhang, Yingke Huang, Jian Zhuang, Wenqiang Hua, Zheng Dong, Lina Zhao, Yi Zhang, Yuhui Dong. A machine learning model for textured X-ray scattering and diffraction image denoising. npj Computational Materials[J]. 2023, https://www.nature.com/articles/s41524-023-01011-w.
[3] Zhen Zhang, Xiaoxue Bi, Pengcheng Li, Chenglong Zhang, Yiming Yang, Yu Liu, Gang Chen, Yuhui Dong, Gongfa Liu, Yi Zhang. Automatic synchrotron tomographic alignment schemes based on genetic algorithms and human-in-the-loop software. Journal of Synchrotron Radiation[J]. 2023, 30(1): 169-178, https://journals.iucr.org/s/issues/2023/01/00/tv5039/index.html.
[4] 李想, 张一, 刘玙, 李鹏程, 胡皓, 王俐文, 何平, 董宇辉, 张承龙. A high-throughput big-data orchestration and processing system for the High Energy Photon Source. Journal of Synchrotron Radiation[J]. 2023, 30(6): [5] Xinyu Pan, Xiaoxue Bi, Zheng Dong, Zhi Geng, Han Xu, Yi Zhang, Yuhui Dong, Chenglong Zhang. Review of development for ptychography algorithm. Acta Phys. Sin[J]. 2023, 72(5): [6] 潘新宇, 毕筱雪, 董政, 耿直, 徐晗, 张一, 董宇辉, 张承龙. 叠层相干衍射成像算法发展综述. 物理学报[J]. 2023, 72(5): 102-122, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7434738&detailType=1.
[7] Dong, Zheng, Chen, Chen, Wen, Kaihua, Zhao, Xiaoyi, Guo, Xihong, Zhou, Zhongzheng, Chang, Guangcai, Zhang, Yi, Dong, Yuhui. A Freestanding Chitin-Derived Hierarchical Nanocomposite for Developing Electrodes in Future Supercapacitor Industry. POLYMERS[J]. 2022, 14(1): http://dx.doi.org/10.3390/polym14010195.
[8] Dong, Zheng, Chen, Sen, Gupta, Himadri S, Zhao, Xiaoyi, Yang, Yiming, Chang, Guangcai, Xue, Jian, Zhang, Yiyang, Luo, Shengnian, Dong, Yuhui, Zhang, Yi. In situ determination of the extreme damage resistance behavior in stomatopod dactyl club. JOURNAL OF SYNCHROTRON RADIATION[J]. 2022, 29(Pt 3): 775-786, https://www.doi.org/10.1107/S1600577522001217.
[9] Liu, Yu, Geng, YanDa, Bi, XiaoXue, Li, Xiang, Tao, Ye, Cao, JianShe, Dong, YuHui, Zhang, Yi. Mamba: a systematic software solution for beamline experiments at HEPS. JOURNAL OF SYNCHROTRON RADIATION[J]. 2022, 29(Pt 3): 664-669, http://dx.doi.org/10.1107/S1600577522002697.
[10] Du, Xuejian, Gao, ZengQiang, Geng, Zhi, Dong, YuHui, Zhang, Heng. Structure and Biochemical Characteristics of the Methyltransferase Domain of RNA Capping Enzyme from African Swine Fever Virus. JOURNAL OF VIROLOGY[J]. 2021, 95(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000619748400004.
[11] Zhu, Zhongzhu, Xu, Han, Hu, Lingfei, Li, Ming, Liu, Peng, Dong, Yuhui, Zhou, Liang. A wave optics model for the effect of partial coherence on coherent diffractive imaging. JOURNAL OF SYNCHROTRON RADIATION[J]. 2021, 28: 499-504, https://www.webofscience.com/wos/woscc/full-record/WOS:000626355600016.
[12] Wang, Shuangyue, Geng, Zhi, Zhang, Heng, She, Zhun, Dong, Yuhui. The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector. FEBS JOURNAL[J]. 2021, 288(19): 5755-5767, http://dx.doi.org/10.1111/febs.15870.
[13] Wen, Haiying, Liu, Guangfeng, Geng, Zhi, Zhang, Heng, Li, Yanhua, She, Zhun, Dong, Yuhui. Structure and SAXS studies unveiled a novel inhibition mechanism of the Pseudomonas aeruginosa T6SS TseT-TsiT complex. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 188: 450-459, http://dx.doi.org/10.1016/j.ijbiomac.2021.08.029.
[14] Zhang, Likui, Yan, Yuhua, Gan, Qi, She, Zhun, Zhu, Keli, Wang, Jinhui, Gao, Zengqiang, Dong, Yuhui, Gong, Yong. Structural and functional characterization of the deep-sea thermophilic bacteriophage GVE2 tailspike protein. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 164: 4415-4422, http://dx.doi.org/10.1016/j.ijbiomac.2020.09.053.
[15] Wen, Haiying, Geng, Zhi, Gao, Zengqiang, She, Zhun, Dong, Yuhui. Characterization of the Pseudomonas aeruginosa T6SS PldB immunity proteins PA5086, PA5087 and PA5088 explains a novel stockpiling mechanism. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2020, 76(Pt 5): 222-227, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000530263400005.
[16] Zhang, Yi, Garrevoet, Jan, Wang, Yanhong, Roeh, Jan Torben, Terrill, Nicholas J, Falkenberg, Gerald, Dong, Yuhui, Gupta, Himadri S, 张一. Molecular to Macroscale Energy Absorption Mechanisms in Biological Body Armour Illuminated by Scanning X-ray Diffraction with In Situ Compression. ACS NANO[J]. 2020, 14(12): 16535-16546, http://dx.doi.org/10.1021/acsnano.0c02879.
[17] Liu, Ying, Gao, Zengqiang, Liu, Guangfeng, Geng, Zhi, Dong, Yuhui, Zhang, Heng. Structural Insights Into the Transcriptional Regulation of HigBA Toxin-Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa. FRONTIERS IN MICROBIOLOGY[J]. 2020, 10: https://doaj.org/article/1cb346be006d4094ad552f2f2af27347.
[18] Zhou, Juan, Gao, Zengqiang, Zhang, Heng, Dong, Yuhui. Crystal structure of the nucleoid-associated protein Fis (PA4853) from Pseudomonas aeruginosa. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2020, 76(Pt 5): 209-215, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000530263400003.
[19] Hu, Menglu, Gao, Zengqiang, Zhou, Qiang, Geng, Zhi, Dong, Yuhui. A noise and artifact suppression using resampling(NASR)method to facilitate de novo protein structure determination. 辐射探测技术与方法(英文)[J]. 2019, 3(3): 247-255, http://lib.cqvip.com/Qikan/Article/Detail?id=7106714880.
[20] Xu, Xuefang, Zhang, Heng, Huang, Ying, Zhang, Yuan, Wu, Changde, Gao, Pengya, Teng, Zhongqiu, Luo, Xuelian, Peng, Xiaojing, Wang, Xiaoyuan, Wang, Dai, Pu, Ji, Zhao, Hongqing, Lu, Xuancheng, Lu, Shuangshuang, Ye, Changyun, Dong, Yuhui, Lan, Ruiting, Xu, Jianguo. Beyond a Ribosomal RNA Methyltransferase, the Wider Role of MraW in DNA Methylation, Motility and Colonization in Escherichia coli O157:H7. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/faf56df12b91467192cfbd60fce4ad94.
[21] Zhun She, Zhi Geng, JianHua Xu, YanHua Li, YuHui Dong. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY[J]. 2019, 28(5): 971-975, [22] Shi, Lingling, Gao, Zengqiang, Zhang, Tianyi, Zhang, Heng, Dong, Yuhui. Crystal structure of the type VI immunity protein Tdi1 (Atu4351) from Agrobacterium tumefaciens. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2019, 75(Pt 3): 153-158, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000460520900003.
[23] Xu, BingShuang, Liu, Min, Zhou, Ke, Geng, Zhi, Gao, ZengQiang, Dong, YuHui, She, Zhun, Liu, QuanSheng. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2019, 514(1): 37-43, http://dx.doi.org/10.1016/j.bbrc.2019.04.061.
[24] She, Zhun, Geng, Zhi, Xu, JianHua, Li, YanHua, Dong, YuHui. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2019, 28(5): 971-975, [25] Kun Tang, Lei Zheng, Yi Dong Zhao, Shu Hu Liu, Chen Yan Ma, Yu Hui Dong. A micro‐focusing and high‐flux‐throughput beamline design using a bending magnet for microscopic XAFS at the High Energy Photon Source. Journal of Synchrotron Radiation[J]. 2019, 26: 1835-1842, https://www.doi.org/10.1107/S160057751900715X.
[26] Zhang, Zhenfeng, Zhao, Mohan, Chen, Yuanyuan, Wang, Li, Liu, Qinghua, Dong, Yuhui, Gong, Yong, Huang, Li. Architectural roles of Cren7 in folding crenarchaeal chromatin filament. MOLECULAR MICROBIOLOGY[J]. 2019, 111(3): 556-569, https://www.webofscience.com/wos/woscc/full-record/WOS:000461081000002.
[27] Geng, Zhi, Hu, Menglu, She, Zhun, Zhou, Qiang, Gao, Zengqiang, Dong, Yuhui. An iterative refinement method combining detector geometry optimization and diffraction model refinement in serial femtosecond crystallography. 辐射探测技术与方法(英文)[J]. 2018, 2(1): 190-199, http://lib.cqvip.com/Qikan/Article/Detail?id=7106714838.
[28] Wang, Hanqian, Liu, Xiaoqing, Zhao, Jintong, Yue, Qingxia, Yan, Yuhua, Gao, Zengqiang, Dong, Yuhui, Zhang, Zhiyong, Fan, Yunliu, Tian, Jian, Wu, Ningfeng, Gong, Yong. Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity. SCIENTIFIC REPORTS[J]. 2018, 8(1): http://www.corc.org.cn/handle/1471x/2202260.
[29] Li, Huanhuan, Yang, Kai, Wang, Wenjia, Niu, Yingbo, Li, Jun, Dong, Yuhui, Liu, Yingfang, Wang, Chihchen, Wang, Lei, Liang, Huanhuan. Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(4): 1192-1202, http://dx.doi.org/10.1074/jbc.M117.797290.
[30] Jia, Xuanyan, Yao, Jianyun, Gao, Zengqiang, Liu, Guangfeng, Dong, YuHui, Wang, Xiaoxue, Zhang, Heng. Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(18): 6812-6823, http://dx.doi.org/10.1074/jbc.RA118.002421.
[31] Zhang, Tianyi, Geng, Zhi, Zhang, Heng, Zhou, Liang, Dong, Yuhui. Electron densitymap evaluation functions for determining the quality of protein crystal structures. 辐射探测技术与方法(英文)[J]. 2018, 2(2): 42-, http://lib.cqvip.com/Qikan/Article/Detail?id=7106713489.
[32] Yuan, Fei, Gao, ZengQiang, Majerciak, Vladimir, Bai, Lei, Hu, MengLu, Lin, XiaoXi, Zheng, ZhiMing, Dong, YuHui, Lan, Ke. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLOS PATHOGENS[J]. 2018, 14(8): http://dx.doi.org/10.1371/journal.ppat.1007232.
[33] Yang, Jingsi, Wang, Fei, Yang, Dan, Zhou, Ke, Liu, Min, Gao, Zengqiang, Liu, Peng, Dong, Yuhui, Zhang, Jianjun, Liu, Quansheng. Structural and biochemical characterization of the yeast HD domain containing protein YGK1 reveals a metal-dependent nucleoside 5 '-monophosphatase. BIOCHEMICALANDBIOPHYSICALRESEARCHCOMMUNICATIONS[J]. 2018, 501(3): 674-681, https://www.webofscience.com/wos/woscc/full-record/WOS:000436057500011.
[34] Dong, Jianshu, Li, Fahui, Gao, Feng, Wei, Jia, Lin, Yajing, Zhang, Yong, Lou, Jizhong, Liu, Guangfeng, Dong, Yuhui, Liu, Lin, Liu, Hongmin, Wang, Jiangyun, Gong, Weimin. Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon. JOURNAL OF MOLECULAR BIOLOGY[J]. 2018, 430(21): 4183-4194, http://dx.doi.org/10.1016/j.jmb.2018.08.015.
[35] Zhang, Zhenfeng, Zhao, Mohan, Wang, Li, Chen, Yuanyuan, Dong, Yuhui, Gong, Yong, Huang, Li. Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA. BIOCHEMICAL JOURNAL[J]. 2017, 474(10): 1727-1739, http://www.corc.org.cn/handle/1471x/2177413.
[36] Yang, Jingsi, Xu, Bingshuang, Gao, Zengqiang, Zhou, Ke, Liu, Peng, Dong, Yuhui, Zhang, Jianjun, Liu, Quansheng. HicAB toxin-antitoxin complex from Escherichia coli: expression and crystallization. ACTACRYSTALLOGRAPHICASECTIONFSTRUCTURALBIOLOGYCOMMUNICATIONS[J]. 2017, 73(Pt 9): 505-510, https://www.webofscience.com/wos/woscc/full-record/WOS:000409298600002.
[37] Yang, Xiaoyun, Li, Yanhua, Gao, Zengqiang, Li, Zongqiang, Xu, Jianhua, Wang, Wenjia, Dong, Yuhui. Structural analysis of Wss1 protein from saccharomyces cerevisiae. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/7fb2675efc6748e98d4e1ef53b356b3a.
[38] Lin, QingPeng, Gao, ZengQiang, Geng, Zhi, Zhang, Heng, Dong, YuHui. Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2017, 73(Pt 8): 463-468, http://www.corc.org.cn/handle/1471x/2176933.
[39] Yang, XiaoYun, Li, ZongQiang, Gao, ZengQiang, Wang, WenJia, Geng, Zhi, Xu, JianHua, She, Zhun, Dong, YuHui. Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2017, 26(10): 2083-2091, http://www.corc.org.cn/handle/1471x/2177080.
[40] Yang, Jingsi, Xu, Bingshuang, Gao, Zengqiang, Zhou, Ke, Liu, Peng, Dong, Yuhui, Zhang, Jianjun, Liu, Quansheng. HicAB toxin-antitoxin complex from Escherichia coli: expression and crystallization. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2017, 73(9): 505-510, https://www.webofscience.com/wos/woscc/full-record/WOS:000409298600002.
[41] Wang, Wenjia, Yang, Xiaoyun, Chang, Guangcai, An, Pengfei, Cha, Kewen, Dong, Yuhui, Liu, Peng. A method to stabilize the incident X-ray energy for anomalous diffraction measurements. JOURNAL OF SYNCHROTRON RADIATION[J]. 2017, 24(4): 781-786, http://www.corc.org.cn/handle/1471x/2177289.
[42] Lin, QingPeng, Gao, ZengQiang, Geng, Zhi, Zhang, Heng, Dong, YuHui. Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2017, 73(8): 463-468, http://www.corc.org.cn/handle/1471x/2176933.
[43] Hu, Haidai, Dong, Jiazhen, Liang, Deguang, Gao, Zengqiang, Bai, Lei, Sun, Rui, Hu, Hao, Zhang, Heng, Dong, Yuhui, Lan, Ke. Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor. JOURNAL OF VIROLOGY[J]. 2016, 90(3): 1158-1168, http://dx.doi.org/10.1128/JVI.01392-15.
[44] Wan, Hua, Otsuka, Yuichi, Gao, ZengQiang, Wei, Yong, Chen, Zhen, Masuda, Michiaki, Yonesaki, Tetsuro, Zhang, Heng, Dong, YuHui. Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd. MOLECULAR MICROBIOLOGY[J]. 2016, 101(5): 757-769, https://search.proquest.com/docview/1827931485.
[45] Yang, XiaoYun, Li, ZongQiang, She, Zhun, Geng, Zhi, Xu, JianHua, Gao, ZengQiang, Dong, YuHui. Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins. FEBS LETTERS[J]. 2016, 590(16): 2787-2796, [46] Chen, Zhen, Zhan, LiHong, Hou, HaiFeng, Gao, ZengQiang, Xu, JianHua, Dong, Cheng, Dong, YuHui. Structural basis for the interaction of BamB with the POTRA3-4 domains of BamA. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2016, 72: 236-244, http://www.corc.org.cn/handle/1471x/2159144.
[47] Yang, Jingsi, Zhou, Ke, Liu, Peng, Dong, Yuhui, Gao, Zengqiang, Zhan, Jianjun, Liu, Quansheng. Structural insight into the E. coli HigBA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 478(4): 1521-1527, https://www.webofscience.com/wos/woscc/full-record/WOS:000384390200006.
[48] Tian, Lei, Zhang, Zhenfeng, Wang, Hanqian, Zhao, Mohan, Dong, Yuhui, Gong, Yong. Sequence-Dependent T:G Base Pair Opening in DNA Double Helix Bound by Cren7, a Chromatin Protein Conserved among Crenarchaea. PLOS ONE[J]. 2016, 11(9): https://doaj.org/article/ca06c518e48345df9e9834b97f77dbad.
[49] Chen, WeiFei, Dai, YangXue, Duan, XiaoLei, Liu, NaNv, Shi, Wei, Li, Na, Li, Ming, Dou, ShouXing, Dong, YuHui, Rety, Stephane, Xi, XuGuang. Crystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwinding. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(6): 2949-2961, http://ir.ihep.ac.cn/handle/311005/247875.
[50] Li, Yanhua, Guo, Zhen, Jin, Li, Wang, Deqiang, Gao, Zengqiang, Su, Xiaodong, Hou, Haifeng, Dong, Yuhui. Mechanism of the allosteric regulation of Streptococcus mutans 2 '-deoxycytidylate deaminase. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2016, 72(7): 883-891, http://www.corc.org.cn/handle/1471x/2176596.
[51] Zhao, Mohan, Zhang, Heng, Liu, Guangfeng, Wang, Li, Wang, Jian, Gao, Zengqiang, Dong, Yuhui, Zhang, Linbo, Gong, Yong. Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI. PLOS ONE[J]. 2016, 11(10): https://doaj.org/article/2ca5537663c24c36b01bfd9529a75ac8.
[52] Wei, Yong, Gao, Zenggiang, Zhang, Heng, Dong, Yuhui. Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 472(4): 592-597, http://ir.ihep.ac.cn/handle/311005/248023.
[53] Zhu, ChunFeng, Wei, Wei, Peng, Xin, Dong, YuHui, Gong, Yong, Yu, XiaoFang. The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2015, 71: 516-524, http://dx.doi.org/10.1107/S1399004714027527.
[54] Li, Qiong, Cheng, Wang, Morlot, Cecile, Bai, XiaoHui, Jiang, YongLiang, Wang, Wenjia, Roper, David I, Vernet, Thierry, Dong, YuHui, Chen, Yuxing, Zhou, CongZhao. Full-length structure of the major autolysin LytA. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2015, 71: 1373-1381, http://dx.doi.org/10.1107/S1399004715007403.
[55] Su, XiaoDong, Zhang, Heng, Terwilliger, Thomas C, Liljas, Anders, Xiao, Junyu, Dong, Yuhui. Protein crystallography from the perspective of technology developments. CRYSTALLOGRAPHY REVIEWSnull. 2015, 21(1-2): 122-153, https://dx.doi.org/10.1080/0889311X.2014.973868.
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[57] Li Qiong, Cheng Wang, Morlot Cecile, Bai XiaoHui, Jiang YongLiang, Wang Wenjia, Roper David I, Vernet Thierry, Dong YuHui, Chen Yuxing, Zhou CongZhao. Full-length structure of the major autolysin LytA. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2015, 71(6): 1373-1381, http://ir.ihep.ac.cn/handle/311005/228438.
[58] Su, Feng, Lu, Liping, Feng, Sisi, Zhu, Miaoli, Gao, Zengqiang, Dong, Yuhui. Synthesis, structures and magnetic properties in 3d-electron-rich isostructural complexes based on chains with sole syn-anti carboxylate bridges. DALTON TRANSACTIONS[J]. 2015, 44(16): 7213-7222, http://ir.ihep.ac.cn/handle/311005/228299.
[59] Wang, Wenjia, Shtykova, Eleonora V, Volkov, Vladimir V, Chang, Guangcai, Zhang, Lianhui, Dong, Yuhui, Liu, Peng. Influence of polychromaticity on particle structure determination in small-angle X-ray scattering. JOURNAL OF APPLIED CRYSTALLOGRAPHY[J]. 2015, 48(6): 1935-1942, http://ir.ihep.ac.cn/handle/311005/228845.
[60] Wei, Yong, Zhan, Lihong, Gao, Zengqiang, Prive, Gilbert G, Dong, Yuhui. Crystal structure of GnsA from Escherichia coli. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2015, 462(1): 1-7, http://dx.doi.org/10.1016/j.bbrc.2015.03.133.
[61] Liu GuanFen, Wang WeJia, Xu JiaHua, Dong YuHui. Small-angle X-ray scattering probe of intermolecular interaction in red blood cells. CHINESE PHYSICS C[J]. 2015, 39(3): http://ir.ihep.ac.cn/handle/311005/228374.
[62] Yan JuanZhi, Zhu MiaoLi, Gao ZengQiang, Dong YuHui. Construction and Photoluminescence Properties of Zn(II)/Cd(II) Complexes with 4-Amino-3,5-propy1-1,2,4-triazole Ligand. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2014, 33(8): 1207-1214, http://ir.ihep.ac.cn/handle/311005/224894.
[63] Zhang Jiulong, Zhang Heng, Liu Ying, Zhan Lihong, She Zhun, Dong Cheng, Dong Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2014, 70(3): 335-338, http://ir.ihep.ac.cn/handle/311005/224794.
[64] Jiang, Ling, Gao, Zengqiang, Li, Yanhua, Wang, Shennan, Dong, Yuhui. Crystal structures and kinetic properties of enoyl-acyl carrier protein reductase broken vertical bar from Candidatus Liberib acterasiaticus. PROTEIN SCIENCE[J]. 2014, 23(4): 366-377, http://dx.doi.org/10.1002/pro.2418.
[65] Zhao, Mohan, Wang, Li, Zhang, Heng, Dong, Yuhui, Gong, Yong, Zhang, Linbo, Wang, Jian. Purification, crystallization and preliminary crystallographic analysis of the 16S rRNA methyltransferase RsmI from Escherichia coli. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2014, 70(Pt 9): 1256-1259, https://www.webofscience.com/wos/woscc/full-record/WOS:000341818600027.
[66] Jiao, Lianying, Ouyang, Songying, Shaw, Neil, Song, Gaojie, Feng, Yingang, Niu, Fengfeng, Qiu, Weicheng, Zhu, Hongtao, Hung, LiWei, Zuo, Xiaobing, Shtykova, V Eleonora, Zhu, Ping, Dong, YuHui, Xu, Ruxiang, Liu, ZhiJie. Mechanism of the Rpn13-induced activation of Uch37. PROTEIN & CELL[J]. 2014, 5(8): 616-630, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5242655&detailType=1.
[67] Liang, Yajing, Gao, Zengqiang, Dong, Yuhui, Liu, Quansheng. Structural and functional analysis show that the Escherichia coli uncharacterized protein YjcS is likely an alkylsulfatase. PROTEIN SCIENCE[J]. 2014, 23(10): 1442-1450, http://ir.ihep.ac.cn/handle/311005/225317.
[68] Wu, Qin, Gao, Zengqiang, Wei, Yong, Ma, Guolin, Zheng, Yuchuan, Dong, Yuhui, Liu, Yangzhong. Conserved residues that modulate protein trans-splicing of Npu DnaE split intein. BIOCHEMICAL JOURNAL[J]. 2014, 461(2): 247-255, http://ir.ihep.ac.cn/handle/311005/224858.
[69] Zhang, Jiulong, Zhang, Heng, Liu, Ying, Zhan, Lihong, She, Zhun, Dong, Cheng, Dong, Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2014, 70(Pt 3): 335-338, https://www.webofscience.com/wos/woscc/full-record/WOS:000332405600012.
[70] Zhou, Liang, Zhang, TianYi, Liu, ZhongChuan, Liu, Peng, Dong, YuHui. A multiple-common-lines method to determine the orientation of snapshot diffraction patterns from single particles. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES[J]. 2014, 70(4): 364-372, http://ir.ihep.ac.cn/handle/311005/224788.
[71] Peng, Shuxia, Zhou, Ke, Wang, Wenjia, Gao, Zengqiang, Dong, Yuhui, Liu, Quansheng. High-resolution crystal structure reveals a HEPN domain at the C-terminal region of S-cerevisiae RNA endonuclease Swt1. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2014, 453(4): 826-832, http://ir.ihep.ac.cn/handle/311005/224857.
[72] Wang Zixi, Li Lanfen, Dong YuHui, Su XiaoDong. Structural and biochemical characterization of MdaB from cariogenic Streptococcus mutans reveals an NADPH-specific quinone oxidoreductase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2014, 70(4): 912-921, http://ir.ihep.ac.cn/handle/311005/224790.
[73] 姜晓明, 王九庆, 秦庆, 董宇辉, 盛伟繁, 程健, 徐刚, 胡天斗, 邓虎, 陈福三, 龙锋利, 陆辉华, 岳军会, 李春华, 孙毅, 陈锦晖, 董海义, 蔡泉, 徐伟, 李明, 常广才, 郑红卫, 陶冶, 刘鹏, 刘景, 孙冬柏, 黎刚, 石泓, 曹建社, 谭园园. 中国高能同步辐射光源及其验证装置工程. 中国科学(物理学·力学·天文学)[J]. 2014, 44(10): 1075-1094, http://ir.ihep.ac.cn/handle/311005/223310.
[74] Cui, Peixin, Wang, Yu, Chu, Wangsheng, Guo, Xiaoyun, Yang, Feifei, Yu, Meijuan, Zhao, Haifeng, Dong, Yuhui, Xie, Yaning, Gong, Weimin, Wu, Ziyu. How water molecules affect the catalytic activity of hydrolases - A XANES study of the local structures of peptide deformylase. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000346300500006.
[75] Zhang, Jiulong, Zhang, Heng, Gao, Zengqiang, Hu, Haidai, Dong, Cheng, Dong, YuHui. Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein. FEBS LETTERS[J]. 2014, 588(10): 1891-1898, https://www.doi.org/10.1016/j.febslet.2014.04.016.
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[79] Chen, Zhen, Gao, Zengqiang, Hu, Haidai, Xu, Jianhua, Zhang, Heng, Dong, Yuhui. Cloning, purification, crystallization and preliminary X-ray studies of the putative type VI secretion immunity protein Tli5 (PA5088) from Pseudomonas aeruginosa. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2014, 70(Pt 7): 903-905, http://www.corc.org.cn/handle/1471x/2198152.
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[84] 陈真, 高增强, 徐建华, 张衡, 董宇辉, Chen Z, Gao ZQ, Hu HD, Xu JH, Zhang H, Dong YH. Cloning, purification, crystallization and preliminary X-ray studies of the putative type VI secretion immunity protein Tli5 (PA5088) from Pseudomonas aeruginosa. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2014, 70(7): 903-905, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338923200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[85] Yan Juanzhi, Zhu Miaoli, Gao Zengqiang, Dong Yuhui. Construction and Photoluminescence Properties of Zn(II)/Cd(II) Complexes with 4-Amino-3,5-propyl-1,2,4-triazole Ligand. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2014, 33(8): 1207-1214, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5218193&detailType=1.
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[90] Liu, Shanshan, Zhang, Wen, Gao, Zengqiang, Ming, Qianqian, Hou, Haifeng, Lan, Wenxian, Wu, Houming, Cao, Chunyang, Dong, Yuhui. NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans. FEBS LETTERS[J]. 2013, 587(16): 2635-2642, http://dx.doi.org/10.1016/j.febslet.2013.06.048.
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[92] Zhang, Heng, Gao, ZengQiang, Wei, Yong, Xu, JianHua, Dong, YuHui. Insights into the Cross-Immunity Mechanism within Effector Families of Bacteria Type VI Secretion System from the Structure of StTae4-EcTai4 Complex. PLOS ONE[J]. 2013, 8(9): http://ir.ihep.ac.cn/handle/311005/224734.
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[105] Wei, Yong, Gao, ZengQiang, Otsuka, Yuichi, Naka, Kenta, Yonesaki, Tetsuro, Zhang, Heng, Dong, YuHui. Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance. MOLECULAR MICROBIOLOGY[J]. 2013, 90(5): 956-965, http://ir.ihep.ac.cn/handle/311005/224085.
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[109] Zhang Yangli, Gao Zengqiang, Zhang Zhenzhen, Luo Miao, Huang Ailong, Dong Yuhui, Wang Deqiang. Cloning, purification, crystallization and preliminary X-ray studies of human a1-microglobulin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2012, 68(6): 692-694, http://ir.ihep.ac.cn/handle/311005/224041.
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[111] Zhang, Heng, Gao, ZengQiang, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Li, LanFen, Su, XiaoDong, Dong, YuHui. The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6. FEBS LETTERS[J]. 2012, 586(8): 1147-1153, http://dx.doi.org/10.1016/j.febslet.2012.03.029.
[112] Dong Cheng, Hou HaiFeng, Yang Xue, Shen YueQuan, Dong YuHui. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2012, 68(2): 95-101, http://ir.ihep.ac.cn/handle/311005/223838.
[113] Wei, Yong, Zhang, Heng, Gao, ZengQiang, Wang, WenJia, Shtykova, Eleonora V, Xu, JianHua, Liu, QuanSheng, Dong, YuHui. Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2012, 179(1): 29-40, http://dx.doi.org/10.1016/j.jsb.2012.04.011.
[114] Liu, ZhongChuan, Xu, Rui, Dong, YuHui. Phase retrieval in protein crystallography. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES[J]. 2012, 68: 256-265, https://www.webofscience.com/wos/woscc/full-record/WOS:000300678400009.
[115] Dong, Cheng, Yang, Xue, Hou, HaiFeng, Shen, YueQuan, Dong, YuHui. Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Addendum (vol 68, pg 1134, 2012). ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. 2012, 68(10): 1437-1437, http://ir.ihep.ac.cn/handle/311005/224138.
[116] Zhang, Heng, Gao, ZengQiang, Su, XiaoDong, Dong, YuHui. Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa. FEBS LETTERS[J]. 2012, 586(19): 3193-3199, http://dx.doi.org/10.1016/j.febslet.2012.06.036.
[117] Zhang, Heng, Gao, ZengQiang, Wei, Yong, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Dong, YuHui. Structural insights into the function of 23S rRNA methyltransferase RlmG (m(2)G1835) from Escherichia coli. RNA[J]. 2012, 18(8): 1500-1509, https://www.webofscience.com/wos/woscc/full-record/WOS:000306420200007.
[118] Zhang, Heng, Wan, Hua, Gao, ZengQiang, Wei, Yong, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Dong, YuHui. Insights into the Catalytic Mechanism of 16S rRNA Methyltransferase RsmE (m(3)U1498) from Crystal and Solution Structures. JOURNAL OF MOLECULAR BIOLOGY[J]. 2012, 423(4): 576-589, http://dx.doi.org/10.1016/j.jmb.2012.08.016.
[119] Dong, Cheng, Yang, Xue, Hou, HaiFeng, Shen, YueQuan, Dong, YuHui. Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY[J]. 2012, 68: 1134-1139, https://www.webofscience.com/wos/woscc/full-record/WOS:000308330000008.
[120] She, Zhun, Gao, ZengQiang, Liu, Ying, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Dong, YuHui. Structural and SAXS analysis of the budding yeast SHU-complex proteins. FEBS LETTERS[J]. 2012, 586(16): 2306-2312, http://dx.doi.org/10.1016/j.febslet.2012.06.024.
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[126] Liu, Ying, Gao, ZengQiang, Liu, ChaoPei, Xu, JianHua, Li, LanFen, Ji, ChaoNeng, Su, XiaoDong, Dong, YuHui. Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 67: 182-187, https://www.webofscience.com/wos/woscc/full-record/WOS:000287030600002.
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[143] Hou, HaiFeng, Liang, YuHe, Li, LanFen, Su, XiaoDong, Dong, YuHui. Crystal structures of Streptococcus mutans 2 '-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP center dot Mg2+. JOURNALOFMOLECULARBIOLOGY[J]. 2008, 377(1): 220-231, http://ir.ihep.ac.cn/handle/311005/227012.
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[145] 郭晓云, 储旺盛, 龚为民, 董宇辉, 谢亚宁, 杨飞飞, Maurizio Benfatto, 吴自玉. 用MXAN拟合钩端螺旋体去甲酰化酶XANES谱. 高能物理与核物理[J]. 2007, 31(2): 199-203, http://lib.cqvip.com/Qikan/Article/Detail?id=23705480.
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（ 1 ） 基于同步辐射的蛋白质和复合体三维结构测定新技术研究, 主持, 国家级, 2009-01--2014-12
（ 2 ） 综合同步辐射小角散射和晶体学解析蛋白质复合物结构的方法学研究, 主持, 国家级, 2010-01--2013-12
（ 3 ） 与环境和纳米生物效应相关的蛋白质研究平台, 主持, 国家级, 2011-01--2012-01
（ 4 ） 蛋白质生命周期过程及调控的分子机制, 参与, 国家级, 2012-01--2016-12
（ 5 ） 基于自由电子X射线激光的结构解析技术, 主持, 部委级, 2014-01--2018-12
（ 6 ） 蛋白质分拣与转运以及降解的结构生物学研究, 主持, 国家级, 2012-01--2016-12
（ 7 ） 依托同步辐射光源的蛋白质晶体学前沿关键技术综合研究, 主持, 国家级, 2017-07--2022-06

已指导学生

高增强  博士研究生  070205-凝聚态物理  

洪才浩  博士研究生  070205-凝聚态物理  

孙少瑞  博士研究生  070205-凝聚态物理  

许锐  博士研究生  070205-凝聚态物理  

刘超培  博士研究生  070205-凝聚态物理  

现指导学生

刘广峰  硕士研究生  070205-凝聚态物理  

刘忠川  博士研究生  070205-凝聚态物理  

曲昆  硕士研究生  070205-凝聚态物理  

佘准  博士研究生  070205-凝聚态物理