基本信息
陈秀兰  女    中国科学院生物物理研究所
电子邮件: chenxiulan@moon.ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号中国科学院生物物理研究所8115室
邮政编码: 100192

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
蛋白质组学

教育背景

2004-09--2009-12   中国科学院生物物理研究所   博士
2000-09--2004-07   华中师范大学生命科学学院   学士

工作经历

   
工作简历
2016-03~2017-03,南丹麦大学,丹麦, 访问学者
2015-01~现在, 中国科学院生物物理研究所, 副研究员
2010-03~2014-12,中国科学院生物物理研究所, 助理研究员
2004-09~2009-12,中国科学院生物物理研究所, 博士
2000-09~2004-07,华中师范大学生命科学学院, 学士

教授课程

ABSP exercise
生命科学研究中的色谱、质谱和组学技术
生物科学研究中的色谱、质谱和蛋白质组学技术
ABSP lab exercise

专利与奖励

   
奖励信息
(1) 中国科学院大学2022年学院级研究生优秀课程, , 研究所(学校), 2022
(2) 中国科学院大学2021年学院级研究生优秀课程, , 研究所(学校), 2021
(3) 中国科学院大学2020年校级研究生优秀课程, , 研究所(学校), 2020
(4) 中国科学院大学2020年学院级研究生优秀课程, , 研究所(学校), 2020
(5) 2018年全国有机质谱学术会议优秀青年论文奖, 其他, 2018
(6) 第六届亚太蛋白质组学大会青年科学家旅行奖, 其他, 2012

出版信息

   
发表论文
(1) Comparative Proteomic Study on The Lesional and Non-lesional Epidermis From Vitiligo Patients, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 第 2 作者
(2) Differential proteomic patterns of plasma extracellular vesicles show potential to discriminate beta-thalassemia subtypes, ISCIENCE, 2023, 第 15 作者
(3) Plasma proteome profiling combined with clinical and genetic features reveals the pathophysiological characteristics of β-thalassemia, ISCIENCE, 2022, 第 13 作者
(4) 磷酸化蛋白质组学研究中磷酸化肽段富集与分离方法研究进展, 生物工程学报, 2022, 通讯作者
(5) Comprehensive Evaluation of Different TiO2-Based Phosphopeptide Enrichment and Fractionation Methods for Phosphoproteomics, CELLS, 2022, 通讯作者
(6) Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species / JUN Pathway, GENOMICS, PROTEOMICS & BIOINFORMATICS, 2021, 通讯作者
(7) Quantitative Proteomics Using Isobaric Labeling: A Practical Guide, GENOMICS, PROTEOMICS & BIOINFORMATICS, 2021, 通讯作者
(8) Comprehensive Analysis of the Proteome and PTMomes of C2C12 Myoblasts Reveals that Sialylation Plays a Role in the Differentiation of Skeletal Muscle Cells, JOURNAL OF PROTEOME RESEARCH, 2021, 第 1 作者
(9) Proteomics reveals the function reverse of MPSSS-treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway, CANCER MEDICINE, 2021, 第 2 作者
(10) Sequential Precipitation and Delipidation Enables Efficient Enrichment of Low-Molecular Weight Proteins and Peptides from Human Plasma, JOURNAL OF PROTEOME RESEARCH, 2020, 其他(合作组作者)
(11) Proteomic Changes of Klebsiella pneumoniae in Response to Colistin Treatment and crrB Mutation-Mediated Colistin Resistance, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 第 4 作者
(12) Proteomic profiling of MIN6 cell-derived exosomes, JOURNAL OF PROTEOMICS, 2020, 第 3 作者
(13) Separation and characterization of extracellular vesicles from human plasma by asymmetrical flow field-flow fractionation, ANALYTICA CHIMICA ACTA, 2020, 第 2 作者
(14) H2A.Z facilitates licensing and activation of early replication origins (vol 35, pg 784, 2019), NATURE, 2020, 第 6 作者
(15) H2A.Z facilitates licensing and activation of early replication origins, NATURE, 2020, 第 6 作者
(16) Comprehensive characterization and proteoform analysis of the hydrophobic surfactant proteins B and C in calf pulmonary surfactant, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 第 4 作者
(17) Integrated proteomic and N-glycoproteomic analyses of doxorubicin sensitive and resistant ovarian cancer cells reveal glycoprotein alteration in protein abundance and glycosylation, ONCOTARGET, 2017, 第 7 作者
(18) Identification and Characterization of 293T Cell-Derived Exosomes by Profiling the Protein, mRNA and MicroRNA Components, PLOS ONE, 2016, 第 2 作者
(19) Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance, SCIENTIFIC REPORTS, 2016, 第 1 作者
(20) Quantitative proteomics using SILAC: Principles, applications, and developments, PROTEOMICS, 2015, 第 1 作者
(21) Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia, JOURNAL OF PROTEOME RESEARCH, 2015, 第 2 作者
(22) Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines, JOURNAL OF PROTEOME RESEARCH, 2015, 第 3 作者
(23) Quantitative Proteomics Analysis Identifies Mitochondria as Therapeutic Targets of Multidrug-Resistance in Ovarian Cancer, THERANOSTICS, 2014, 第 1 作者
(24) Phosphoproteomic Analysis of Protein Phosphorylation Networks in Tetrahymena thermophila, a Model Single-celled Organism, MOLECULAR & CELLULAR PROTEOMICS, 2014, 第 2 作者
(25) Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth, CELL RESEARCH, 2014, 第 8 作者
(26) Chronic high glucose induced INS-1 beta cell mitochondrial dysfunction: A comparative mitochondrial proteome with SILAC, PROTEOMICS, 2013, 第 1 作者
(27) Angiotensin IV upregulates the activity of protein phosphatase 1 alpha in Neura-2A cells, PROTEIN & CELL, 2013, 
(28) Mitochondria in the pathogenesis of diabetes: a proteomic view, PROTEIN & CELL, 2012, 第 1 作者
(29) Purification, identification and profiling of serum amyloid A proteins from sera of advanced-stage cancer patients, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2012, 第 6 作者
(30) Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution, JOURNAL OF SEPARATION SCIENCE, 2011, 第 6 作者
(31) Phosphoproteome Analysis of Rat L6 Myotubes Using Reversed-Phase C18 Prefractionation and Titanium Dioxide Enrichment, JOURNALOFPROTEOMERESEARCH, 2010, 第 5 作者
(32) The profile of Mitochondrial Proteins and their Phosphorylation Signaling Network in INS-1β cell, Journal of Proteome Research, 2010, 第 1 作者
(33) Enhanced MALDI-TOF MS Analysis of Phosphopeptides Using an Optimized DHAP DAHC Matrix, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010, 第 5 作者
(34) Preliminary Quantitative Profile of Differential Expression between Rat L6 Myoblasts and Myotubes by Stable Isotope Labeling by Amino acids in Cell Culture, PROTEOMICS, 2010, 第 2 作者
(35) Mammalian mitochondrial proteomics:insight into mitochondrial functions and mitochondria-related diseases, Experts review of Proteomics, 2010, 第 1 作者
(36) Proteomic analysis of the mitochondria from C. elegans, Proteomics, Proteomics, 2009, 第 5 作者
(37) Discovery and identification of potential biomarkers of pediatric Acute Lymphoblastic Leukemia, PROTEOME SCIENCE, 2009, 第 10 作者

科研活动

   
科研项目
( 1 ) 人体血液循环系统蛋白质组表达谱, 参与, 国家任务, 2014-01--2018-12
( 2 ) 唾液酸糖基化修饰对骨骼肌分化的影响及其作用机制的研究, 负责人, 国家任务, 2020-01--2022-12