重金属（离子态、颗粒态）的健康风险、靶点识别与作用机理研究

工作经历

2021 - 至今，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，研究员

2016 - 2021，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，副研究员

2014 - 2015，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，助理研究员

2011 - 2013，法国国家科学研究院（CNRS），Lab Chim Analyt Bioinorgan & Environm，博士后，合作导师: Prof. Sandra Mounicou，Prof. Ryszard Lobinski

社会兼职

1. 中国仪器仪表学会分析仪器分会原子光谱专业委员会委员

2. 中国毒理学会分析毒理委员会委员

3. Journal of Environmental Sciences、Environment & Health、Reviews of Environmental Contamination and Toxicology、《环境化学》等期刊编委或青年编委

1. 中国科学院青年创新促进会优秀会员（2023）

2. 中国科学院大学首届青年教师教学基本功大赛二等奖（2023）

3. 北京市自然科学二等奖（第五完成人，2022）

4. 国家基金委优秀青年科学基金（2019）

5. 中国科学院青年创新促进会会员（2018）

6. 陈国珍奖学金（2010）

7. 黄本立奖学金（2009）

2023

◆ Wang R. Chen Y. Chen J. Ma M. Xu, M.* Liu S. Integration of transcriptomics and metabolomics for unveiling the toxicological profile in the liver of mice exposed to uranium(VI) in drinking water. Environmental Pollution 2023, 335, 122296.

◆ Wang X. Xu L. Ma M. Xu M.* Zhou Q. Liu S. Jiang G. A Novel Strategy for Visualizing, Tracing and Measuring the Gastrointestinal Absorption of Silver Nanoparticles. Advanced Functional Materials 2023, 33, 2302366.

◆ Qi M.^# Wang X.^# Chen J. Liu Y. Liu Y.* Jia J. Li L. Yue T. Gao L. Yan B. Zhao B. Xu M.* Transformation, Absorption and Toxicological Mechanisms of Silver Nanoparticles in the Gastrointestinal Tract Following Oral Exposure. ACS Nano 2023, 17, 8851–8865.

◆ Xu L. Wang X. Xu M.* Liu S. Single-Particle Hyperspectral Imaging for Monitoring of Gold Nanoparticle Aggregates in Macrophages. Journal of Physical Chemistry B 2023, 127, 3231–3240.

◆ Ma M. Wang R.* Xu M.* Thorium(IV) Triggers Ferroptosis through Disrupting Iron Homeostasis and Heme Metabolism in the Liver Following Oral Ingestion. Journal of Hazardous Materials 2023, 452, 131217.

◆ Chen J.^# Ma M.^# Wang R. Gao M. Hu L. Liu S. Xu M.* Roles of Glutathione Peroxidase 4 on the Mercury-Triggered Ferroptosis in Renal Cells: Implications for the Antagonism between Selenium and Mercury. Metallomics 2023, 15, mfad014.

◆ Xu L. Xu M.* Sun X. Feliu N. Feng, L. Parak W. J.* Liu S.* Quantitative comparison of gold nanoparticle delivery via the enhanced permeation and retention (EPR) effect and mesenchymal stem cell (MSC)-based targeting. ACS Nano 2023, 17, 2039–2052.

◆ Xu L. Wang X. Wang R. Liu S. Xu M.* Engineered macrophages: a safe-by-design approach for the tumor targeting delivery of sub-5 nm gold nanoparticles. Small 2023, 19, 2205474.

2022

◆ Chen J. Wang R. Ma M. Gao L. Zhao B. Xu M.* Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS)–based strategies applied for the analysis of metal-binding protein in biological samples: an update on recent advances. Analytical and Bioanalytical Chemistry 2022, 414, 7023-7033.

2021

◆ Ma M. Wang R. Xu L. Du J. Xu M.* Liu S. Emerging Investigator Series: Enhanced peroxidase-like activity and improved antibacterial performance of palladium nanosheet by alginate-corona. Environmental Science: Nano 2021, 8, 3511-3523.

◆ 王煦栋，刘思金，徐明* 地下水铀污染与饮用水中铀的健康风险.环境化学 2021, 40, 1-12.

2020

◆ 徐明，阚海东*，桑楠，刘思金. 持久性有毒污染物环境健康研究的现状与思考. 中国科学院院刊 2020, 35, 1337–1343.

◆ Chen Y. Ma J.* Xu M.* Liu S. Antiviral nanoagents: more attention and effort needed? Nano Today 2020, 35, 100976.

◆ Ma M.^# Wang R.^# Xu L. Xu M.* Liu S. Emerging health risks and underlying toxicological mechanisms of uranium contamination: lessons from the past two decades. Environment International 2020, 145, 106107.

◆ 马明昊，徐明*，刘思金. 氧化石墨烯的表面化学修饰及纳米-生物界面作用机理. 化学学报 2020, 78, 877-887.

◆  Xu L. Xu M.* Wang R. Yin Y. Lynch I. Liu S.* The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials. Small 2020, 16, 2003691.

◆ Wang S. Ren L. Qi Y. Chen Y. Wang R. Ma M. Xu M.* Liu S.* Two-dimensional nanoparticles for the delivery of anticancer drugs and cancer therapy, Frontiers of Nanoscience, 2020, 16, 151-199.

2019

◆ Xu M.* Yang Q. Xu L. Rao Z. Cao D. Gao M. Liu S. Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies, Particle and Fibre Toxicology, 2019, 16, 46.

2018

◆ Xu M. Mohamed Soliman M. G. Sun X. Pelaz B. Feliu N. Parak W. J.* Liu S.* How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles, ACS Nano, 2018, 12, 10104-10113.

◆ Zhu J.^# Xu M.^# Wang F. Gao M. Zhang Z. Xu Y. Chen W. Liu S. Low-dose exposure of graphene oxide significantly increases metal toxicity to macrophages by altering their cellular priming state, Nano Research, 2018, 11, 4111-4122.

◆ Wang X. Cheng W. Yang Q. Niu H. Liu Q. Liu Y. Gao M. Xu M.* Xu A. Liu S. Huang X.* Du Y. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles, Journal of Environmental Sciences, 2018, 69, 217-226.

◆  任泉仲^#，徐立宁^#，徐明*，刘思金. 大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展, 中国科学：化学, 2018, 48, 1260–1268.

2017

◆ Zhu J. Xu M.* Gao M. Zhang Z. Xu Y. Xia T. Liu S.* Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents, ACS Nano, 2017, 11, 2637-2651.

2016

◆ Xu M.^# Zhu J.^# Wang F. Xiong Y. Wu Y. Wang Q. Weng J.* Zhang Z.* Chen W. Liu S.* Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation, ACS Nano, 2016, 10, 3267-3281.

◆ 徐明，王哲，刘思金*.  纳米银生物过程及影响的研究进展, 中国材料进展, 2016, 35, 28-35.

2015

◆ Guo W. Zhang J. Li W. Xu M.* Liu S.* Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, Journal of Environmental Sciences, 2015, 34, 155-164.

◆ 徐明，杨利民，王秋泉*. 硒-汞双元素标记策略识别硒蛋白/多肽. 分析化学,  2015, 43 (9), 1265-1271.

2006-2014

◆ Xu M. Frelon S. Simon O. Lobinski R. Mounicou S.* Development of a non-denaturing 2D gel electrophoresis protocol for screening in vivo uranium-protein targets in Procambarus clarkii with laser ablation ICP MS followed by protein identification by HPLC–Orbitrap MS, Talanta, 2014, 128, 187-195.

◆ Xu M. Frelon S, Simon O. Lobinski R. Mounicou S.* Non-denaturating isoelectric focusing gel electrophoresis for uranium–protein complexes quantitative analysis with LA-ICP MS, Analytical and Bioanalytical Chemistry, 2014, 406 (4), 1063-1072.

◆ Xu M. Bijoux H. Gonzalez P. Mounicou S.* Investigating the response of cuproproteins from oysters (Crassostrea gigas) after waterborne copper exposure by metallomic and proteomic, Metallomics, 2014, 6 (2), 338-346.

◆ Xu M. Yang L. Wang Q.* Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS, Metallomics, 2013, 5 (7), 855-860.

◆ Xu M. Yang L. Wang Q.* A way to probe the microenvironment of free sulfhydryls in intact proteins with a series of monofunctional organic mercurials, Chemistry - A European Journal, 2012, 18 (44), 13989-13993.

◆ 徐明，严晓文，杨利民，王秋泉*. 化学标记与蛋白质/多肽的识别检测. 中国科学：化学, 2011, 41, 663-677.

◆ Xu M. Yan X. Xie Q. Yang L. Wang Q.* Dynamic labeling strategy with 204Hg-isotopic methylmercurithiosalicylate for absolute peptide and protein quantification, Analytical Chemistry, 2010, 82 (5), 1616-1620.

◆ Xu M. Deng G. Liu S. Chen S. Cui D. Yang L. Wang Q.* Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum, Metallomics, 2010, 2 (7), 469-473.

◆ Xu M. Yang L. Wang Q.* Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography, Journal of Analytical Atomic Spectrometry, 2008, 23 (11), 1545-1549.

◆ 徐明，杨利民，王秋泉*. 人体血浆中硒蛋白P提取方法初探. 南昌大学学报.理科版,  2006, 30S, 621-622.

承担科研项目：

1. 国家自然科学基金面上项目，基于光谱/质谱成像技术的纳米银胃肠道转化与亚器官空间分布研究，2024-2027，主持.

2. 国家重点研发计划子课题，区域土壤重金属污染的生物内暴露图谱，2022-2026，主持.

3. 国家自然科学基金面上项目，饮用水铀暴露诱发的肾脏毒性特征与细胞死亡机理，2022-2025，主持.

4. 中国科学院B类先导科技专项培育项目子课题，污染物的生物分子靶点与标志物识别及作用机制，2021-2022，主持.

5. 国家自然科学基金优秀青年科学基金，环境污染物的毒性效应与机制，2020-2022，主持.

6. 国家自然科学基金青年科学基金，基于金属组学揭示纳米银肝细胞毒性的分子机制，2015-2017，主持.

7. 中国科学院战略性先导科技专项B类子课题，阐明典型污染物对肿瘤恶化和去分化的分子机制，2014-2019，主持.

8. 科技部973项目子课题，有机含氟纳米材料的毒理学机制，2015-2019，主持

9. 科技部973项目，典型人工纳米材料的水环境过程、生物效应及其调控研究，2014-2018，参与.