086000-生物与医药
083001-环境科学
071009-细胞生物学

干细胞毒理学，环境科学
分子生物学
发育生物学

2000-08--2006-03   University of California，Riverside   博士后
1989-09--1998-10   University of Rome   学士/硕士

   

2014-03~现在, 中国科学院生态环境研究中心, 研究员（干细胞毒理学课题组组长）
2010-07~2014-03,Icahn School of Medicine at Mount Sinai, New York,, Postdoctoral Fellow
2006-07~2010-06,University of California, Riverside, CA, Postdoctoral Fellow
2000-08~2006-03,University of California，Riverside, 博士后
1989-09~1998-10,University of Rome, 学士/硕士

环境毒理学研究方法
干细胞毒理学
现代生物学技术在环境健康研究中的应用
环境毒理与健康危害（干细胞毒理基础与进展）

   

（1） 中国科学院国际科技合作奖, 特等奖, 院级, 2022
（2） Best Poster Award, 特等奖, 研究所（学校）, 2006
（3） Outstanding Talk Award, 特等奖, 研究所（学校）, 2004
（4） Best Teaching Assistant Award, 特等奖, 研究所（学校）, 2002
（5） Chancellor Prestigious Fellowship, 特等奖, 研究所（学校）, 2000

（ 1 ） 诱导人多能干细胞分化为肺泡细胞或肺泡类器官的培养基及方法, 2021, 专利号: CN113215080A

（ 2 ） 一种肝脏类器官模型及其建立方法和应用, 2019, 专利号: CN110373380A

（ 3 ） 一种筛选和/或评价物质的方法及其应用, 2019, 专利号: CN110031613A

（ 4 ） 一种微孔模具, 2019, 专利号: CN208914398U

   

（1） Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model, CHEMOSPHERE, 2023, 第 6 作者
（2） Pollution effects on retinal health: A review on current methodologies and findings, TOXICOLOGY AND INDUSTRIAL HEALTH, 2023, 通讯作者
（3） Adverse Events During Pregnancy Associated With Entecavir and Adefovir: New Insights From a Real-World Analysis of Cases Reported to FDA Adverse Event Reporting System, FRONTIERS IN PHARMACOLOGY, 2022, 第 8 作者
（4） Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants, Environmental Science & Technology, 2022, 通讯作者
（5） Environmentally relevant exposure to TBBPA and its analogues may not drastically affect human early cardiac development, ENVIRONMENTAL POLLUTION, 2022, 第 6 作者
（6） Perfluorinated iodine alkanes promoted neural differentiation of mESCs by targeting miRNA-34a-5p in Notch-Hes signaling, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 第11作者
（7） In vivo and in vitro transcriptomics meta-analyses reveal that BPA may affect TGF-beta signaling regardless of the toxicology system employed, ENVIRONMENTAL POLLUTION, 2021, 通讯作者
（8） TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway, JOURNAL OF HAZARDOUS MATERIALS, 2021, 通讯作者
（9） Development of Human Lung Induction Models for Air Pollutants' Toxicity Assessment, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 通讯作者
（10） Evaluation of the effects of low nanomolar bisphenol A-like compounds’ levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models, JOURNAL OF HAZARDOUS MATERIALS, 2021, 通讯作者
（11） A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 通讯作者
（12） Silver nanoparticles (AgNPs) and AgNO3 perturb the specification of human hepatocyte-like cells and cardiomyocytes, SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 通讯作者
（13） Tetrabromobisphenol A(TBBPA): A controversial environmental pollutant, Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 通讯作者
（14） Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length, FOOD AND CHEMICAL TOXICOLOGY, 2020, 通讯作者
（15） Non-cytotoxic silvernanoparticlelevelsperturbhumanembryonicstemcelldependent specification of the cranial placode in part via FGF signaling, Journal of Hazardous Materials, 2020, 通讯作者
（16） The short-chain perfluorinated compounds PFBS,PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation, The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 通讯作者
（17） Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling, JOURNAL OF HAZARDOUS MATERIALS, 2020, 通讯作者
（18） Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells, CHEMOSPHERE, 2020, 通讯作者
（19） F–53B and PFOS treatments skew human embryonic stem cell invitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway, ENVIRONMENTAL POLLUTION, 2020, 通讯作者
（20） 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 通讯作者
（21） Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 通讯作者
（22） Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 通讯作者
（23） Genetic diversity of diazotrophs and total bacteria in the phyllosphere of Pyrus serotina, Prunus armeniaca, Prunus avium, and Vitis vinifera, CANADIAN JOURNAL OF MICROBIOLOGY, 2019, 第 6 作者
（24） Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 通讯作者
（25） Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 通讯作者
（26） Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo, TOXICOLOGY LETTERS, 2019, 通讯作者
（27） Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges, STEM CELLS AND DEVELOPMENT, 2019, 通讯作者
（28） Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity, JOURNAL OF HAZARDOUS MATERIALS, 2019, 通讯作者
（29） Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 通讯作者
（30） New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells, ARCHIVES OF TOXICOLOGY, 2019, 第 7 作者
（31） TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 通讯作者
（32） 干细胞毒理学在大气污染健康风险评估中的应用, The application of stem cell toxicology in the health risk assessments of atmospheric pollution, 中国科学：化学, 2018, 
（33） Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 通讯作者
（34） Pfoa and pfos disrupt the generation of human pancreatic progenitor cells, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2018, 通讯作者
（35） Response to Comment on "TBBPA and its alternatives disturb the early stages of neural development by interfering with the NOTCH and WNT pathways", ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 通讯作者
（36） YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells, STEM CELL REPORTS, 2018, 第 7 作者
（37） Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 5 作者
（38） Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an invitro mouse stem cell differentiation model, CHEMOSPHERE, 2018, 通讯作者
（39） DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development, ENVIRONMENTAL POLLUTION, 2018, 通讯作者
（40） Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro, Journal of Interdisciplinary Nanomedicine, 2018, 通讯作者
（41） Prospects and frontiers of stem cell toxicology, STEM CELLS AND DEVELOPMENT, 2017, 通讯作者
（42） NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression, STEM CELL REPORTS, 2017, 通讯作者
（43） Coating with spermine-pullulan polymer enhances adenoviral transduction of mesenchymal stem cells, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 
（44） Stem cell toxicology:a powerful tool to assess pollution effects on human health, Stem cell toxicology:a powerful tool to assess pollution effects on human health, 国家科学评论：英文版, 2016, 第 3 作者
（45） Stem cell toxicology: a powerful tool to assess pollution effects on human health, NATIONAL SCIENCE REVIEW, 2016, 通讯作者
（46） Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 通讯作者
（47） Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells, JOURNAL OF ENVIRONMENTAL SCIENCES, 2015, 通讯作者
（48） Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells, JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2015, 通讯作者
（49） The Rise of Stem Cell Toxicology, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 通讯作者
（50） Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency, NATURE, 2013, 第 4 作者
（51） Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor Nanog, STEM CELLS, 2013, 第 2 作者
（52） Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 2 作者
（53） Oct4 links multiple epigenetic pathways to the pluripotency network., Cell Res., 2011, 第 1 作者
（54） Max is acetylated by p300 at several nuclear localization residues, BIOCHEMICAL JOURNAL, 2007, 第 1 作者
（55） Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription †, MOLECULAR AND CELLULAR BIOLOGY, 2005, 
（56） Environmentally relevant exposure to TBBPA and its analogues may not drastically affect human early cardiac development, ENVIRONMENTAL POLLUTION, 第 6 作者

   

（ 1 ） 中国科学院战略性先导科技专项（典型污染物的环境暴露与健康危害机制 项目三）, 负责人, 中国科学院计划, 2014-07--2019-06
（ 2 ） 利用多能干细胞研究环境污染物的健康效应及风险评估, 负责人, 国家任务, 2016-01--2019-12
（ 3 ） 环境小分子与表观遗传的交互作用, 参与, 中国科学院计划, 2017-01--2021-12
（ 4 ） 基于人胚胎干细胞胰腺分化模型研究全氟化合物与糖尿病发病的相关性, 负责人, 国家任务, 2019-01--2022-12
（ 5 ） 高通量新型污染物生物筛选系统构建与环境监测应用（课题一新型污染物生物识别与感知的调控机制与基因编辑基础））, 参与, 国家任务, 2020-11--2024-10
（ 6 ） 环境污染与健康危害, 参与, 国家任务, 2021-01--2025-12
（ 7 ） Pollution effects on the developing human brain and their alleviation, 负责人, 国家任务, 2022-01--2023-12
（ 8 ） 典型环境污染物对人脑发育的影响, 负责人, 国家任务, 2021-01--2022-12
（ 9 ） 基于多能干细胞荧光敲除细胞系建立高通量模型评 价空气污染物肺毒性, 负责人, 地方任务, 2023-10--2025-09

（1）Transcriptomic integration analysis uncover common bisphenol A effects across species and tissues primary mediated by disruption of JUN/FOS, EGFR, ER, PPARG and P53 pathway   2023-09-20
（2）The environmental pollutants PFOS and PFOA disrupt the specification and function of pancreatic and endocrine progenitor cells in vitro.   2018-12-02
（3）Stem cell toxicology is a powerful system to assess the developmental toxicity of environmental pollution.   2018-03-10
（4）Assessment of the developmental toxicity of BPA, BPF and BPS, with a stem cell toxicology system   2017年“香港浸会大学-中国科学院生态环境研究中心伙伴国家重点实验室以及环境科学联合研究所”环境科学论坛   2017-04-16
（5）Stem cell toxicology: a powerful tool to assess pollution effects on human health   国际毒理学学会第56届年会   2017-03-12
（6）The rise of stem cell toxicology   第13届持久性有毒污染物国际研讨会   2016-10-10
（7）Stem Cell Toxicology   2016-06-21
（8）Stem cell toxicology: a powerful tool to assess Bisphenol A (BPA) derivatives- toxicity   第12届持久性有毒污染物国际研讨会   Nuoya Yin, Xinglei Yao, Francesco Faiola   2015-11-15