LU Xuemei

Research Areas

Evolutionary genomics of complex traits and cancer in human and animal model systems


1997-09--2000-06    Kunming Institute of Zoology, CAS,   Ph.D. degree

1994-09--1997-06   South China Agricultural University,   Master degree


Work Experience

2009-06~, Beijing Institute of Genomics, Chinese Academy of Sciences, professor

2005-09~2009-05,Sun Yet-Sen University, Associate Professor

2003-09~2005-07,University of Chicago, postdoc

2002-01~2003-07,the Center for Reproduction of Endangered Species, Zoological Society of San Diego, Asistant Professor

2000-07~2001-10, Kunming Institute of Zoology, CAS,   Ph.D. degree, Asistant Professor



(1) The Ecology and Evolution of Cancer – The ultra-microevolutionary process, Annual Review of Genetics, 2016, Correspoding author
(2) Functional conservation of both CDS- and 3’UTR- located miRNA binding sites between species, Molecular biology and evolution, 2015, Correspoding author

(3) siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells, Oncotarget, 2015, Correspoding author
(4) Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution, Proc Natl Acad Sci U S A, 2015, Correspoding author
(5) Dynamic methylation during normal development, aging, and tumorigenesis, BioMed research international, 2014, Correspoding author
(6) Deciphering the heterogeneity in DNA methylation patterns during stem cell differentiation and reprogramming, BMC genomics, 2014, Correspoding author
(7) The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation, Genome research, 2014, Correspoding author
(8) Monitoring Hip and Elbow Dysplasia Achieved Modest Genetic Improvement of 74 Dog Breeds over 40 Years in USA, PLoS One, 2013, First author
(9) Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology., BMC Genomics, 2013, Correspoding author
(10) Sex, sex chromosome and gene expression., BMC Biol. , 2011,First author 
(11) Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by a cell-population genetic analysis of whole-genome data, PNAS, 2011, First author
(12)  Genome-wide misexpression of X-linked vs.autosomal genes associated with hybrid male sterility, Genome Res, 2010, First author
(13)  Faster evolution of Z-linked duplicate genes in chicken, J Genet Genomics, 2010, Correspoding author


1.Method and device for matching character strings. CN102929900A. Shaoping Ling, Xuemei Lu.

2.Composition for treating cancers and use thereof. CN102895672A. Chunyan Li, Fang Yang, Wensheng Liu, Yu Wang, Xuemei Lu, Chung-I Wu

3.Construction method of Small RNA-Seq library for screening early diagnosis targets of tumor. CN102586892A. Chunyan Li , Encheng Dong, Zhenzhen Liu, Xuemei Lu, Chung-I Wu

4.Trace DNA-based next-generation sequencing library construction method. CN103938277A. Zuyu Yang, Kaile Wang, Dafei Wu, Xuemei Lu, Chung-I Wu

Research Interests

Dr. LU’s lab focuses on evolutionary genomics of complex traits and cancer in human and animal model systems using genomic and population genetic approaches. Our current research interests are in addressing 1) the evolutionary process and diversity within and between cellular populations/tumors, 2) evolution of complex traits and artificial selection in animals, and 3) evolution of gene regulatory in cells and polyploidy animal species by analyzing genomic, epigenomic and transcriptional variations.

Phenotypic evolution is driven by mutation, drift, migration and natural selection. Genetic variation is the basis of phenotypic changes, which affects the phenotypes by altering the regulation of gene expression. Adaptation can happen at various levels, population, organism, or cellular. Based on the identification of genomic variations, we are focusing on understanding the genomic basis and evolution of gene regulation in order to bridge the genotypic variations and phenotypic changes at various levels. Our previous transcriptional analysis sheds light on understanding the genetic basis of gene-gene interaction during speciation and the evolution of evolvability of miRNA regulation in biodiversity. We also work on the evolution of the population of cancerous cells (adaptation at cellular level) with carrying out large-scale sequencing. Cells from within a tumor and from the adjacent normal tissues may be treated as human individuals sampled from all over the world. We are testing the action of selection both within and between tumors by comparing the observations with the null model, in which all clones have the same neutral growth rate. Regardless of whether and how selection influences the genetic diversity, a large amount of neutral diversity, possibly orders of magnitude higher than the "adaptive" diversity, is expected to exist. If the mutations are involved in cellular properties that are selectively advantageous to tumor cell motility, migration, proliferation or drug resistance, they may increase the fitness variation and the likelihood of selective expansion of different subclones within a tumor. The phenotypic changes can mostly be represented by transcriptome profiles. In addition, epigenetic changes can be crucial in cellular but not organismal evolution. Therefore, the selectivity of the genetic and epigenetic divergence within a tumor for cellular fitness, which results in phenotypic variations, will to be examined.


(1)Liver Diseases and Tumorigenesis: from Bench to Bedside   Xuemei Lu   2016-04-25
(2)2016 Tumor heterogeneity seminar   Xuemei Lu   2016-04-22
(3)2015 Congress of genetics society of China   Xuemei Lu   2015-08-14
(4)Genetic diversity and evolutionary forces within and between tumors     International Bioinformatics Workshop(IBW2015)   Xuemei Lu     2015-07-09
(5)UK-China Personalised Medicine Symposium   Xuemei Lu   2015-01-13
(6)EVOLUTIONARY GENETICS and GENOMICS   Jialin Liu, Tao Li, Yuezheng Zhang   2014-10-08



刘珍珍  硕士研究生  085238-生物工程  

戚甫荣  硕士研究生  085211-计算机技术  

张翠云  硕士研究生  071021-生物信息学  

任通  硕士研究生  0710Z1-基因组学  

邓强  硕士研究生  085211-计算机技术  

吴欣  硕士研究生  085238-生物工程  

李雪凝  硕士研究生  085238-生物工程  


李涛  博士研究生  0710Z1-基因组学  

李亚威  博士研究生  071007-遗传学  

罗燕婷  博士研究生  0710J3-生物信息学  

戚甫荣  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

胡振宇  硕士研究生  0710Z1-基因组学  

殷利夺  博士研究生  0710Z1-基因组学  

魏昀旸  硕士研究生  0710Z1-基因组学  

夏瑞燕  硕士研究生  0710Z1-基因组学  

钱雨   博士研究生  0710Z1-基因组学  

冯璥  博士研究生  0710Z1-基因组学  

Research Grant Support

The Strategic Priority Research Program of the Chinese Academy of Sciences,

Major Research Project of Nature Science Foundation of China (NSFC),

National High-tech R&D Program (863 Program),

Hundred Talents Program of the CAS,

National Basic Research Program of China (973 Program)(Yali Hou),

CAS Youth Innovation Promotion Association(Yali Hou),

The Youth Foundation of National Natural Science (Yali Hou)