复杂性状和肿瘤的进化基因组学

博士生、硕士生

071022-基因组学
071021-生物信息学
071007-遗传学

进化基因组学
肿瘤基因组学
分子进化

1997-09--2000-06   中国科学院昆明动物研究所   博士
1994-09--1997-06   华南农业大学   硕士

研究生

博士

   

2009-06~现在, 中国科学院北京基因组研究所, 研究员
2005-09~2009-05,中山大学, 副教授
2003-09~2005-07,美国芝加哥大学, 博士后
2002-01~2003-07,美国圣地亚哥野生动物协会濒危动物保护研究中心, 研究助理
2000-07~2001-10,中国科学院昆明动物研究所, 助理研究员

群体遗传与分子进化
人类基因组学研究-进展与应用
进化生物学
基因组学前沿

   

[1] 冯璥, 李涛, 何文彬, 吕雪梅. 一种对PRRSV具有特异性免疫刺激作用的CpG-ODN及其应用. CN: CN112626073A, 2021-04-09.
[2] 冯璥, 李涛, 何文彬, 吕雪梅. 一种对PRRSV具有特异性免疫刺激作用的CpG-ODN及其应用. CN: CN112410344A, 2021-02-26.
[3] 冯璥, 李涛, 何文彬, 吕雪梅. 一种对PRRSV具有特异性免疫刺激作用的CpG-ODN及其应用. CN: CN112322626A, 2021-02-05.
[4] 阮珏, 王开乐, 沈栩, 吕雪梅, 吴仲义. 一种DNA扩增方法. CN: CN105463066A, 2016-04-06.
[5] 王开乐, 阮珏, 吕雪梅, 吴仲义. 改进的测序文库及其制备和应用. CN: CN105420348A, 2016-03-23.
[6] 阮珏, 王开乐, 吕雪梅, 吴仲义. 测序文库及其制备和应用. CN: CN104695027A, 2015-06-10.
[7] 李春燕, 刘珍珍, 邵小健, 吕雪梅, 吴仲义. 肝癌检测试剂盒. CN: CN104357566A, 2015-02-18.
[8] 杨祖玉, 王开乐, 吴大飞, 吕雪梅, 吴仲义. 以痕量DNA为基础的二代测序文库构建方法. CN: CN103938277A, 2014-07-23.
[9] 凌少平, 吕雪梅. 一种字符串匹配的方法及装置. CN: CN102929900A, 2013-02-13.
[10] 李春燕, 杨芳, 刘稳升, 王瑜, 吕雪梅, 吴仲义. 用于恶性肿瘤治疗的组合物及其应用. CN: CN102895672A, 2013-01-30.
[11] 李春燕, 董恩成, 刘珍珍, 吕雪梅, 吴仲义. 筛选肿瘤早期诊断靶标的Small RNA-Seq库的构建方法. CN: CN102586892A, 2012-07-18.

   

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[13] 麻富强, 陆广安, 陈青建, 阮永森, 李欣, 吕雪梅, 李春燕. 通过对基因转录的动态和全局分析揭示miRNAs协同稳定基因表达的作用. 科学通报:英文版[J]. 2020, 65(24): 2130-2140, http://lib.cqvip.com/Qikan/Article/Detail?id=7104014150.
[14] Yin, Liduo, Banerjee, Sharmi, Fan, Jiayi, He, Jianlin, Lu, Xuemei, Xie, Hehuang. Epigenetic regulation of neuronal cell specification inferred with single cell "Omics" data. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2020, 18: 942-952, http://dx.doi.org/10.1016/j.csbj.2020.04.007.
[15] 吕雪梅. The use of SARS-CoV-2-related coronaviruses from bats and pangolins to polarize mutations in SARS-Cov-2, 2020. Science China_Life Sciences. 2020, [16] Liu, Qingyun, Wei, Jianhao, Li, Yawei, Wang, Mei, Su, Jun, Lu, Yonghui, Lopez, Mariana G, Qian, Xueqin, Zhu, Zhaoqin, Wang, Haiying, Gan, Mingyun, Jiang, Qi, Fu, YunXin, Takiff, Howard, Comas, Inaki, Li, Feng, Lu, Xuemei, Fortune, Sarah M, Gao, Qian. Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments. SCIENCE ADVANCES[J]. 2020, 6(22): http://dx.doi.org/10.1126/sciadv.aba4901.
[17] Hou, Yali, Qi, Furong, Bai, Xue, Ren, Tong, Shen, Xu, Chu, Qin, Zhang, Xiquan, Lu, Xuemei. Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals. BMC GENOMICS[J]. 2020, 21(1): https://doaj.org/article/314610e6c7de4c4bb6f6a174d798387d.
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[19] Bai, Xue, Liu, Zhenzhen, Shao, Xiaojian, Wang, Di, Dong, Encheng, Wang, Yan, Wu, ChungI, Yuan, Yunfei, Lu, Xuemei, Li, Chunyan. The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma. PLOS ONE[J]. 2019, 14(2): http://dx.doi.org/10.1371/journal.pone.0211581.
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[21] Qi, Furong, Yang, Airong, Ambreen, Sadaf, Bai, Xue, Hou, Yali, Lu, Xuemei. Birth and death of Mx genes and the presence/absence of genes regulating Mx transcription are correlated with the diversity of anti-pathogenicity in vertebrate species. MOLECULAR GENETICS AND GENOMICS[J]. 2019, 294(1): 121-133, https://www.webofscience.com/wos/woscc/full-record/WOS:000457456800011.
[22] Yin, Liduo, Luo, Yanting, Xu, Xiguang, Wen, Shiyu, Wu, Xiaowei, Lu, Xuemei, Xie, Hehuang. Virtual methylome dissection facilitated by single-cell analyses. EPIGENETICS & CHROMATIN[J]. 2019, 12(1): http://dx.doi.org/10.1186/s13072-019-0310-9.
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（ 1 ） 结合人工诱变和全基因组测序建立复杂性状新型研究模型, 主持, 国家级, 2011-01--2013-12
（ 2 ） 肿瘤的个体化RNA干扰治疗, 参与, 国家级, 2012-01--2015-12
（ 3 ） 细胞群体的适应性进化规律和进化关键基因的识别, 主持, 国家级, 2012-01--2015-12
（ 4 ） 在模式系统中研究复杂性状演化和稳定性的网络调控, 主持, 部委级, 2014-06--2019-05
（ 5 ） 肿瘤生长、迁移及其进化驱动力的群体基因组学解析, 主持, 国家级, 2016-01--2018-12
（ 6 ） DNA甲基化对高原适应的调控作用, 主持, 部委级, 2017-05--2018-06
（ 7 ） 肿瘤细胞群体适应性权衡的生态进化机制, 主持, 国家级, 2018-01--2021-12
（ 8 ） 2017年度基因组学、干细胞、组织再生学术研讨会, 主持, 国家级, 2017-08--2017-12

（1）Rapid generation of copy number variation may lead to very high mutation load in cancer cell population   2017-08-28
（2）Evolution of cancer cell populations   吕雪梅   2016-04-25
（3）肿瘤内部和之间异质性的演化及其医学意义   2016肿瘤异质性学术研讨会   凌少平、杨芳、杨祖玉、吕雪梅、吴仲义   2016-04-22
（4）细胞分化过程中DNA 甲基化的变异度和保真性的时空动态变化   2015中国遗传学学会大会   赵磊、吕雪梅、谢荷煌等   2015-08-14
（5）Genetic diversity and evolutionary forces within and between tumors    第十二届国际生物信息学论坛（IBW2015）   吕雪梅   2015-07-09
（6）Genetic diversity and evolutionary forces within and between HCC tumors   Xuemei Lu   2015-01-13
（7）r- and K-selection revisited with free-living mammalian cells   Jialin Liu, Tao Li, Yuezheng Zhang   2014-10-08

已指导学生

刘珍珍  硕士研究生  085238-生物工程  

戚甫荣  硕士研究生  085211-计算机技术  

张翠云  硕士研究生  071021-生物信息学  

任通  硕士研究生  0710Z1-基因组学  

邓强  硕士研究生  085211-计算机技术  

吴欣  硕士研究生  085238-生物工程  

李雪凝  硕士研究生  085238-生物工程  

现指导学生

李涛  博士研究生  0710Z1-基因组学  

李亚威  博士研究生  071007-遗传学  

罗燕婷  博士研究生  0710J3-生物信息学  

戚甫荣  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

胡振宇  硕士研究生  0710Z1-基因组学  

殷利夺  博士研究生  0710Z1-基因组学  

魏昀旸  硕士研究生  0710Z1-基因组学  

夏瑞燕  硕士研究生  0710Z1-基因组学  

钱雨   博士研究生  0710Z1-基因组学  

冯璥  博士研究生  0710Z1-基因组学