1. 疾病相关的多肽组装结构及其调控的分子机制
2. 基于多肽纳米结构的体外诊断技术
3. 基于扫描探针显微技术的纳米表征方法

招收物理化学、纳米化学、胶体与界面化学、材料物理与化学、生物化学等背景的硕士生和博士生。

070304-物理化学（含：化学物理）

表面物理化学
纳米生物学

1999-09--2002-06 北京大学化学与分子工程学院 理学博士学位
1996-09--1999-06 山东大学化学学院 理学硕士学位
1992-09--1996-06 山东大学化学学院 理学学士学位

-- 研究生

-- 博士

2002年7月-2004年6月，北京大学化学与分子工程学院从事博士后研究工作
2004年7月-2010年2月，国家纳米科学中心副研究员
2007年10月-2008年11月，美国麻省理工学院生物医学工程中心做访问学者
2010年3月至今，国家纳米科学中心研究员

纳米科学与技术

       1.           Niu, Lin¹; Liu, Lei¹; Xi, Wenhui¹; (Equal contribution) Li, Qiang; Han, Qiusen; Yu, Yue; Huang, Qunxing; 

       Qu, Fuyang; Xu, Meng; Li, Yibao; Du, Huiwen; Yang, Rong; Cramer, Jacob; Gothelf, Kurt; Dong, Mingdong;  

       Besenbacher, Flemming; Zeng, Qingdao; Wang, Chen*; Wei, Guanghong*; Yang, Yanlian*, “Synergistic

       inhibitory effect of Peptide-Organic Co-assemblies on Amyloid Aggregation”, ACS Nano, 2016, 10 (4), 

       4143–4153.

2.            Lei Liu^†, Lin Niu^†, (Equal contribution) Meng Xu, Qiusen Han, Hongyang Duan, Mingdong Dong, Flemming Besenbacher, Chen Wang*, Yanlian Yang*, “Molecular tethering effect of C-terminus of amyloid peptide Aβ42”, ACS Nano, 2014, 8(9), 9503-9510.

3.            Paula Lopes, Meng Xu, Min Zhang, Ting Zhou, Yanlian Yang,* Chen Wang and Elena E. Ferapontova* “Direct electrochemical and AFM detection of amyloid-beta peptide aggregation on basal plane HOPG”, Nanoscale, 2014, 6, 7853.

4.            Lin Niu, Lei Liu, Meng Xu, Jacob Cramer, Kurt V. Gothelf, Mingdong Dong, Flemming Besenbacher, Qingdao Zeng, Yanlian Yang* and Chen Wang*, “Transformation of b-sheet structures of the amyloid peptide induced by molecular modulators” Chem. Commun. 2014, 50 (64), 8923 – 8926.

5.            Linling Bai, Yimeng Du, Jiaxi Peng, Yi Liu, Yanmei Wang, Yanlian Yang* and Chen Wang*, “Peptide-based isolation of circulating tumor cells by magnetic nanoparticles”, J. Mater. Chem. B, 2014, 2, 4080-4088.

6.            Shelley A. Claridge, Jeffrey J. Schwartz, Miles A. Silverman, John C. Thomas, Yanlian Yang,* Chen Wang,* and Paul S. Weiss*, “Differentiating Amino Acid Residues and Side Chain Orientations in Peptides Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013,135(49), 18528–18535.

7.            Yanlian Yang, Chen Wang*, “Single Molecule Studies on Individual Peptides and Peptide Assemblies on Surfaces”, Phil. Trans. R. Soc. A, 2013, 371, 20120311. Invited Review.

8.            Ting Zhou,# Axel Llizo,# (Equal Contribution), Chen Wang, Guiying Xu*, Yanlian Yang*, “Nanostructure-induced DNA Condensation”, Nanoscale, 2013, 5, 8288–8306. Invited Review

9.            Min Zhang, Xiaobo Mao, Yue Yu, Chenxuan Wang, Yanlian Yang,* Chen Wang* “Nanomaterials for reducing amyloid cytotoxicity”, Adv. Mater., 2013, 25(28), 3780–3801. Invited Review.

10.        Xiaobo Mao^‡, Yuanyuan Guo^‡, Yin Luo^‡, (Equal contribution) Lin Niu, Lei Liu, Xiaojing Ma, Huibin Wang, Yanlian Yang*, Guanghong Wei*, Chen Wang*, “Sequence Effects on Peptide Assembly Characteristics Observed by Using Scanning Tunneling Microscopy” J. Am. Chem. Soc. 2013, 135 (6), 2181–2187.

11.        Min Zhang¹, Xiaobo Mao¹, (Equal contribution) Chenxuan Wang, Wenfeng Zeng, Chunling Zhang, Zhongjun Li, Ying Fang, Yanlian Yang,* Wei Liang*, Chen Wang*, “The Effect of Graphene oxide on Conformation Change, Aggregation and Cytotoxicity of HIV-1 Regulatory Protein (Vpr)”, Biomaterials, 2013, 34(4), 1383-1390.

12.        Chenxuan Wang, Aihua Yang, Xia Li, Denghua Li, Min Zhang, Huiwen Du, Chao Li, Yuanyuan Guo, Xiaobo Mao, Mingdong Dong, Flemming Besenbacher, Yanlian Yang*, Chen Wang* “Observation of molecular inhibition and binding structures of amyloid peptides” Nanoscale, 2012, 4(6), 1895-1909, Invited review.

13.        Xiaobo Mao, Chenxuan Wang, Xingkui Wu, Xiaojing Ma, Lei Liu, Lan Zhang, Lin Niu, Yuanyuan Guo, Denghua Li, Yanlian Yang*, Chen Wang*, “Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies” Proc. Natl. Acad. Sci. USA. 2011, 108(49), 19605-19610.

14.        Chenxuan Wang,^# Xiaobo Mao,^# (Co-first authors) Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibing Wang, Yanlian Yang* and Chen Wang* “Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy”, Chem. Commun., 2011, 47(38), 10638–10640.

15.        Lei Liu^#, Lan Zhang^# (Co-first authors), Lin Niu, Meng Xu, Xiaobo Mao, Yanlian Yang*, Chen Wang*, “Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-like Molecules” ACS Nano, 2011, 5(7), 6001-6007.

16.        Xiaobo Mao, Chenxuan Wang, Xiaojing Ma, Min Zhang, Lei Liu, Lan Zhang, Lin Niu, Qingdao Zeng, Yanlian Yang*, Chen Wang* “Molecular level studies on binding modes of labeling molecules with polyalanine peptides” Nanoscale, 2011, 3(4), 1592-1599.

17.        Lei Liu, Lan Zhang, Xiaobo Mao, Lin Niu, Yanlian Yang,* and Chen Wang* “Chaperon-Mediated Single Molecular Approach Toward Modulating Ab Peptide Aggregation” Nano Lett., 2009, 9(12), 4066-4072.

18.        Yanlian Yang, Chen Wang*, “Hierarchical construction of self-assembled low-dimensional molecular architectures observed by using scanning tunneling microscopy” Chem. Soc. Rev., 2009, 38(9), 2576-2589. Invited review.

19.        Xiaojing Ma, Lei Liu (Equal contribution), Xiaobo Mao, Lin Niu, Ke Deng, Weihui Wu, Yanmei Li, Yanlian Yang*, Chen Wang^*, “Amyloid-β (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM” J. Mol. Biol. 2009, 388(4), 894–901.

20.        Yanlian Yang, Ulung Khoe, Xiumei Wang, Akihiro Horii, Hidenori Yokoi and Shuguang Zhang “Designer Self-assembling Peptide Nanomaterials”, Nano Today, 2009, 4(2), 193-210. Invited review.

21.        Yanlian Yang, Chen Wang* “Solvent effects on two-dimensional molecular self-assemblies investigated by using scanning tunneling microscopy” Curr. Opin. Colloid and Interf. Sci., 2009, 14(2), 135–147. Invited review.

22.        Yanlian Yang, Qilin Chan, Xiaojing Ma, Yongtao Shen, Ke Deng, Xizeng Feng*, Chen Wang*, “Electrical Conformational Bistability of Dimesogen Molecules with a Molecular Chord Structure”, Angew. Chem. Int. Ed. 2006, 45(41), 6889-6893.

 

1、中国科学院科研装备研制项目，YZ201317、同步研究生物大分子二级结构与聚集行为的精密等温滴定微量量热计， 2013/10-2015/09，39万元、执行中、参与。
2、中国科学院战略性先导科技专项（A类），XDA09030306、恶性肿瘤体外诊断，2013/07-2017/12、500万元、执行中、子课题负责人。
3、国家自然科学基金面上项目，21273051、基于特异性识别多肽的循环肿瘤细胞检测新方法研究，2013/01-2016/12，81万元、执行中、项目负责人。
4、国家自然科学基金重大研究计划重点支持项目，91127043、疾病相关多肽组装结构及其调控的分子水平研究，2012/1-2015/12，300万元、执行中、核心骨干。 
5、国家重大科学研究计划，2007CB936800、纳米尺度光学、电学、力学高分辨检测研究，课题二：纳米尺度的电学性质探针测量方法（2007CB936802）2007.7.1-2011.8.31，已结题。课题负责人。
6、国家自然科学基金委面上项目，20973043“分子组装体电场响应特性的SPM研究”， 2010.1-2012.12，已结题。项目负责人。 

已指导学生

白林灵  博士研究生  070304-物理化学  

张敏  博士研究生  070304-物理化学  

现指导学生

段鸿洋  博士研究生  070304-物理化学  

黄群星  硕士研究生  070304-物理化学  

黄欢  博士研究生  070304-物理化学  

刘长亮  硕士研究生  080502-材料学  

李文哲  博士研究生  070304-物理化学  

高厚乾  硕士研究生  080502-材料学